45S5 Bioactive Glass Granules: Wholesale Price & OEM Supplier 

45S5 Bioactive Glass Granules are a specific class of bioactive material composed of 45% silica, 24.5% sodium oxide, 24.5% calcium oxide, and 6% phosphorus pentoxide by weight. Known for their ability to bond with both hard and soft tissues, these granules are critical in regenerative medicine, dental applications, and advanced cosmetic formulations. As a premier strategic sourcing partner, Jinan Meiyi Biotechnology Co., Ltd. provides high-purity, regulatory-compliant 45S5 granules to R&D laboratories and manufacturers globally, ensuring consistent particle size distribution and biological efficacy for OEM and wholesale requirements.

What Are 45S5 Bioactive Glass Granules?

45S5 Bioglass® is the original bioactive glass composition discovered by Professor Larry Hench in 1969. The “45S5” designation refers to its specific chemical makeup: 45 wt% SiO2, with a molar ratio of Na2O/CaO of 1:1 and a P2O5/SiO2 ratio of 0.06. This precise stoichiometry is crucial because it allows the material to dissolve at a controlled rate in physiological fluids, releasing ions that stimulate cellular activity.

Unlike inert biomaterials that merely occupy space, 45S5 bioactive glass granules actively interact with the body. Upon contact with body fluids, they form a hydroxycarbonate apatite (HCA) layer on their surface. This layer is chemically and structurally similar to the mineral phase of human bone, enabling a strong chemical bond rather than just a mechanical fixation. For formulators and medical device manufacturers, understanding this mechanism is essential for product development.

Chemical Composition and Structural Integrity

The efficacy of 45S5 granules relies heavily on purity and homogeneity. Impurities or deviations in the oxide ratios can significantly alter the dissolution rate, potentially leading to ineffective bonding or undesirable pH changes in the surrounding tissue. High-quality granules must meet strict pharmaceutical-grade standards.

• Silica (SiO2): Forms the glass network backbone.
• Sodium Oxide (Na2O): Acts as a network modifier, increasing solubility.
• Calcium Oxide (CaO): Essential for HCA layer formation and bone bonding.
• Phosphorus Pentoxide (P2O5): Critical for matching the crystalline structure of bone mineral.

Jinan Meiyi Biotechnology ensures that all sourced 45S5 granules undergo rigorous batch-level specification verification. We partner exclusively with certified manufacturers who adhere to internationally accepted quality management systems, guaranteeing that every gram of material meets the theoretical 45S5 composition.

How 45S5 Bioactive Glass Works: The Mechanism of Action

Understanding the biological response to 45S5 granules is vital for researchers developing next-generation therapeutics. The process occurs in a sequential series of stages, transforming the glass surface into a biologically active interface.

Stage 1: Ion Exchange and Dissolution

When 45S5 granules are exposed to aqueous environments (such as blood serum or tissue fluid), alkali ions (Na+ and K+) rapidly exchange with hydrogen ions (H+) from the fluid. This initial burst increases the local pH, which has been shown to have antimicrobial properties and stimulates osteoblast proliferation.

Stage 2: Silica Network Breakdown

Following ion exchange, the silicate network breaks down, releasing soluble silica and calcium ions into the surrounding medium. This dissolution is controlled; if the glass dissolves too quickly, it loses structural integrity before tissue integration occurs. If it dissolves too slowly, it fails to trigger the necessary biological response.

Stage 3: Formation of Amorphous Calcium Phosphate Layer

The released calcium and phosphate ions reprecipitate on the glass surface, forming an amorphous calcium phosphate-rich layer. This step is the precursor to bone bonding.

Stage 4: Crystallization into Hydroxycarbonate Apatite (HCA)

The amorphous layer crystallizes into HCA, which is identical to the mineral component of bone. This HCA layer allows for the adsorption of growth factors and proteins, facilitating the attachment and differentiation of stem cells and osteoblasts. For cosmetic applications, this same mechanism promotes collagen synthesis and skin regeneration.

Key Applications of 45S5 Bioactive Glass Granules

The versatility of 45S5 bioactive glass allows it to be used across multiple industries, from heavy industrial medical implants to delicate cosmetic serums. Jinan Meiyi Biotechnology supports clients in diverse sectors by providing granules tailored to specific application needs.

1. Bone Tissue Engineering and Regeneration

In orthopedics and dentistry, 45S5 granules are used as bone void fillers. They promote rapid bone growth in defects caused by trauma, tumor removal, or spinal fusion surgeries. The granules can be packed into irregular shapes, providing a scaffold for new bone to grow while gradually resorbing and being replaced by natural tissue.

2. Dental Care and Desensitization

One of the most widespread commercial uses of 45S5 technology is in toothpaste and dental composites. The granules occlude open dentinal tubules, effectively reducing tooth sensitivity. In restorative dentistry, bioactive glass particles are incorporated into composite resins to enhance bonding strength and prevent secondary caries through ion release.

3. Medical Aesthetics and Skincare

In the cosmetics industry, micronized 45S5 bioactive glass granules are gaining traction for their anti-aging and skin-repairing properties. By stimulating fibroblast activity, these granules enhance collagen and elastin production. They are frequently formulated into:

• Anti-aging Serums: To improve skin elasticity and reduce fine lines.
• Wound Healing Creams: To accelerate recovery after laser treatments or microneedling.
• Dermal Fillers: As a biostimulatory agent to support volume restoration.

Jinan Meiyi Biotechnology specializes in supplying raw materials for the medical aesthetics sector. Our team understands the unique regulatory and formulation challenges of this industry, offering technical consultation to ensure seamless integration of bioactive granules into cosmetic bases.

4. Wound Care and Soft Tissue Repair

Bioactive glass fibers and granules are used in advanced wound dressings. The alkaline pH created during dissolution inhibits bacterial growth, while the released ions promote angiogenesis (formation of new blood vessels) and soft tissue regeneration. This makes 45S5 particularly valuable for treating chronic wounds, such as diabetic ulcers.

Why Choose Jinan Meiyi Biotechnology for 45S5 Granules?

Sourcing high-performance bioactive materials requires more than just finding a supplier; it demands a partner who understands the scientific and regulatory landscape. Jinan Meiyi Biotechnology Co., Ltd., headquartered in Jinan, Shandong Province, operates as a subsidiary of Pacific Kangtai Scientific Instruments. We position ourselves at the intersection of scientific rigor and market responsiveness.

Strategic Sourcing and Quality Assurance

Unlike traditional manufacturers, Jinan Meiyi Biotechnology functions as a strategic sourcing and quality-assured distribution partner. We do not engage in raw material manufacturing ourselves. Instead, we leverage a well-established global supply chain network to maintain long-term cooperative relationships with internationally recognized suppliers. This model allows us to offer:

• Consistent Access: Reliable supply of technically advanced, regulatory-compliant materials.
• Rigorous Evaluation: All raw materials undergo comprehensive evaluation based on efficacy data, stability profiles, and compatibility with modern formulation standards.
• Documentation Traceability: Each batch is accompanied by full technical dossiers, including Certificates of Analysis (CoA), Safety Data Sheets (SDS), and regulatory status summaries.

Expertise in Cosmetics and Medical Aesthetics

Our core strength lies in our deep specialization in bioactive technology applications within the cosmetics and medical aesthetics industries. Our scientifically trained team stays at the forefront of international research, monitoring emerging trends in dermatological research and minimally invasive aesthetics. We integrate these insights into our portfolio strategy, helping clients reduce sourcing complexity while maintaining full confidence in material consistency.

Partnership-Oriented Service Model

We serve clients across Asia, Europe, and North America, with a particular focus on supporting R&D laboratories, Contract Development and Manufacturing Organizations (CDMOs), and aesthetic clinics. Our service philosophy is rooted in partnership rather than transaction. We provide technical consultation, regulatory intelligence sharing, and collaborative problem-solving to facilitate faster, safer, and more effective translation of bioactive science into real-world benefits.

Technical Specifications and Particle Size Selection

Selecting the correct particle size is critical for the intended application. 45S5 bioactive glass granules are available in various micron ranges, each suited for different functional requirements.

Jinan Meiyi Biotechnology works with clients to determine the optimal particle size distribution for their specific formulation. Whether you are developing a injectable dermal filler or a robust bone void filler, our team ensures the selected granules meet your rheological and biological targets.

Comparison: 45S5 Bioactive Glass vs. Other Biomaterials

When selecting materials for regenerative applications, engineers and formulators often compare 45S5 bioactive glass with other common biomaterials such as hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP).

As illustrated, 45S5 bioactive glass offers a unique combination of osteostimulation, angiogenesis, and antimicrobial properties that inert or purely resorbable materials lack. This makes it the preferred choice for applications where rapid integration and infection control are priorities.

OEM and Wholesale Procurement Guide

For businesses looking to integrate 45S5 bioactive glass granules into their product lines, understanding the procurement process is key to efficiency and compliance. Jinan Meiyi Biotechnology streamlines this process through a transparent and responsive operational model.

Step 1: Requirement Analysis and Consultation

Begin by defining your application parameters. Are you formulating a topical cream or a surgical implant? What is the target particle size? Our technical team engages in collaborative problem-solving to align material specifications with your product goals. We assess clinical relevance and technological differentiation to recommend the best grade of 45S5 granules.

Step 2: Sample Evaluation and Testing

Before bulk procurement, we provide samples for your R&D team to test. This phase allows you to verify compatibility with your formulation base, check for stability, and confirm biological performance. Jinan Meiyi Biotechnology supports this phase with detailed technical dossiers and regulatory guidance.

Step 3: Quality Verification and Compliance Check

Once the sample is approved, we proceed to batch verification. Our quality assurance framework centers on supplier qualification and batch-level specification verification. We ensure that all materials comply with regional regulations, whether you are selling in the EU, North America, or Asia. This includes verifying ISO certifications and biomedical safety standards.

Step 4: Logistics and Delivery

We maintain strict control over storage conditions and shipping protocols. Bioactive glass is sensitive to moisture, which can prematurely initiate the dissolution process. Therefore, we ensure that all granules are packaged in moisture-proof, sealed containers and shipped under controlled conditions to preserve product integrity from origin to end-user.

Frequently Asked Questions (FAQ)

Is 45S5 Bioactive Glass safe for cosmetic use?

Yes, 45S5 bioactive glass is widely regarded as safe for cosmetic applications when used in appropriate concentrations and particle sizes. Micronized grades are non-abrasive and biocompatible, making them suitable for topical skincare products. However, manufacturers must conduct safety assessments in accordance with local cosmetic regulations (e.g., EU Cosmetic Regulation 1223/2009).

What is the shelf life of 45S5 granules?

When stored in a cool, dry place in sealed packaging, 45S5 bioactive glass granules typically have a shelf life of 2-3 years. Exposure to humidity should be avoided, as it can cause premature surface reaction. Jinan Meiyi Biotechnology ensures proper packaging and provides storage guidelines to maximize shelf life.

Can 45S5 granules be combined with other active ingredients?

Yes, 45S5 granules are compatible with many common cosmetic and pharmaceutical ingredients. However, due to the alkaline pH shift during dissolution, formulators should test compatibility with pH-sensitive actives. Our technical team can provide guidance on formulation strategies to maintain stability.

Does Jinan Meiyi Biotechnology manufacture the glass?

No, Jinan Meiyi Biotechnology does not engage in manufacturing raw materials. We function as a strategic sourcing and quality-assured distribution partner. We partner with certified manufacturers that adhere to internationally accepted quality management systems, ensuring you receive high-integrity, functionally validated ingredients backed by robust documentation.

What is the minimum order quantity (MOQ) for wholesale?

MOQs vary depending on the grade and particle size of the 45S5 granules. As a flexible partner, we aim to support both large-scale CDMOs and specialized R&D labs. Please contact our sales team for specific MOQ details tailored to your project needs.

Conclusion: Partnering for Innovation in Bioactive Technology

45S5 Bioactive Glass Granules represent a cornerstone material in modern regenerative medicine and advanced cosmetics. Their unique ability to bond with living tissue and stimulate cellular regeneration offers unparalleled opportunities for product innovation. However, realizing this potential requires access to high-purity materials and expert technical support.

Jinan Meiyi Biotechnology Co., Ltd. stands as a dependable bridge between upstream innovation and downstream application. By leveraging our globally integrated supply chain, rigorous quality assurance, and deep industry expertise, we enable our clients to develop differentiated, science-backed solutions with confidence. Whether you are an R&D laboratory exploring new formulations or a manufacturer scaling up production, our partnership-oriented approach ensures you receive not just materials, but strategic value.

Ready to elevate your product formulation with premium 45S5 Bioactive Glass Granules?

Contact Jinan Meiyi Biotechnology today to request technical datasheets, samples, or a customized wholesale quote. Let our experts guide you through the selection process to ensure regulatory compliance and optimal performance.

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