45S5 Bioactive Glass Powder Manufacturer & Wholesale Price 

45S5 Bioactive Glass Powder is a specific composition of silicate glass (45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5 by weight) designed to bond with living bone and soft tissue. As a specialized provider of high-performance raw materials, Jinan Meiyi Biotechnology Co., Ltd. supplies high-purity, micronized 45S5 powder for biomedical implants, dental composites, and regenerative medicine. Our strategic sourcing model supports R&D labs, medical device manufacturers, and industrial-scale production, ensuring consistent particle size distribution, strict chemical stoichiometry, and compliance with international biocompatibility standards.

What is 45S5 Bioactive Glass Powder?

45S5 Bioglass® represents the first generation of bioactive materials capable of forming a strong bond with host bone. The name “45S5” denotes its chemical composition: 45 wt% silica (SiO2) and a 5:1 molar ratio of calcium to phosphorus. Unlike inert biomaterials such as titanium or alumina, which rely on mechanical fixation, 45S5 bioactive glass powder initiates a dynamic series of surface reactions when exposed to physiological fluids.

This material was originally developed by Professor Larry Henchey at the University of Florida. Today, it remains the gold standard in bioactivity research and clinical application. The powder form allows for versatile integration into polymers, cements, and scaffolds, enabling engineers and clinicians to tailor the mechanical and biological properties of final medical devices.

The Science Behind Bioactivity

The efficacy of 45S5 powder lies in its unique ability to undergo rapid ion exchange. Upon contact with body fluids, sodium and calcium ions leach from the glass surface, increasing the local pH and triggering the precipitation of a carbonated hydroxyapatite (HCA) layer. This HCA layer is chemically and structurally similar to the mineral phase of natural bone, facilitating direct osteoconduction and osteostimulation.

For manufacturers and researchers, understanding this mechanism is critical. The rate of reaction is dependent on several factors, including:

• Particle Size: Smaller particles have a higher surface-area-to-volume ratio, accelerating the formation of the HCA layer.
• Composition Purity: Deviations from the exact 45S5 stoichiometry can significantly reduce or eliminate bioactivity.
• Processing Method: Melt-derived versus sol-gel synthesis affects the structural network and dissolution rate.

Supply Chain Integrity and Quality Assurance

Producing and sourcing high-grade 45S5 bioactive glass powder requires precise control over raw material selection, melting temperatures, and milling processes. At Jinan Meiyi Biotechnology Co., Ltd., headquartered in Jinan, Shandong Province, we operate as a subsidiary of Pacific Kangtai Scientific Instruments (Jinan) Co., Ltd., dedicated to the research, development support, and commercialization of bioactive technologies. While we do not engage in direct manufacturing, we function as a strategic sourcing and quality-assured distribution partner, leveraging long-term cooperative relationships with internationally recognized, certified manufacturers.

Our operational model prioritizes reliability and transparency. We ensure that every batch of 45S5 powder adheres to strict Good Manufacturing Practices (GMP) and international quality management systems. This partnership approach allows us to provide batch-to-batch consistency, which is vital for regulatory approval in medical device and aesthetic applications.

Raw Material Selection and Verification

The process begins with high-purity raw materials, including silicon dioxide, sodium carbonate, calcium carbonate, and phosphorus pentoxide. Impurities such as heavy metals must be minimized to prevent cytotoxicity. These components are mixed in exact proportions and melted at temperatures exceeding 1300°C by our certified manufacturing partners. This high-temperature melt ensures a homogeneous glass structure without crystalline phases that could compromise bioactivity.

Jinan Meiyi Biotechnology maintains a disciplined curation methodology. All raw materials undergo comprehensive evaluation prior to inclusion in our portfolio, with selection criteria grounded in efficacy data, stability profiles, and compatibility with modern formulation standards. We verify elemental composition and ensure adherence to the 45S5 formula through rigorous documentation review and batch-level specification verification.

Milling and Particle Size Engineering

After quenching and crushing, the glass frit is milled to achieve specific particle size distributions. We offer customized micronization services through our supply network to meet diverse application needs:

• Nano-sized powders (<1 µm): Ideal for enhancing the bioactivity of polymer composites and creating injectable pastes.
• Micro-sized powders (1–10 µm): Commonly used in dental restorative materials and coating formulations.
• Granular powders (100–800 µm): Suitable for bone void fillers and scaffold fabrication via sintering.

Our advanced logistics and quality control systems ensure narrow particle size distributions, reducing agglomeration and improving flowability for downstream processing.

Quality Assurance Protocols

Every batch of 45S5 powder distributed by Jinan Meiyi Biotechnology undergoes rigorous testing before release. Our quality assurance framework centers on supplier qualification and documentation traceability, including:

• X-Ray Diffraction (XRD): To confirm the amorphous nature of the glass and detect any unwanted crystallization.
• Inductively Coupled Plasma (ICP) Spectroscopy: To verify elemental composition and ensure adherence to the 45S5 formula.
• Scanning Electron Microscopy (SEM): To analyze particle morphology and surface texture.
• In Vitro Bioactivity Testing: Simulated Body Fluid (SBF) tests to measure the rate of HCA layer formation, confirming functional bioactivity.

Each raw material is accompanied by full technical dossiers, including Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and regulatory status summaries where applicable.

Key Technical Specifications

When sourcing 45S5 bioactive glass powder for industrial or medical use, precise technical parameters are essential for product performance. The following table outlines the standard specifications for our premium grade powder. Custom specifications are available upon request for specialized R&D projects.

Applications of 45S5 Bioactive Glass Powder

The versatility of 45S5 powder enables its use across a broad spectrum of biomedical and healthcare industries. From orthopedic implants to daily care products, the material’s ability to stimulate tissue regeneration drives innovation in multiple sectors. Jinan Meiyi Biotechnology serves clients across Asia, Europe, and North America, with particular strength in supporting R&D laboratories, contract development and manufacturing organizations (CDMOs), and aesthetic clinics seeking differentiated, science-backed solutions.

1. Orthopedics and Bone Regeneration

In orthopedic surgery, 45S5 powder is a key component in bone graft substitutes. It is often sintered into porous scaffolds or mixed with polymers like poly-L-lactic acid (PLLA) to create composite materials. These composites combine the osteoconductivity of bioactive glass with the mechanical strength of polymers, providing structural support while promoting new bone growth.

Clinical studies have shown that 45S5-based implants integrate faster with host bone compared to traditional hydroxyapatite coatings. This reduces recovery time and improves long-term implant stability.

2. Dentistry and Oral Care

The dental industry is one of the largest consumers of 45S5 bioactive glass powder. Its applications include:

• Dentin Hypersensitivity Treatment: Toothpastes containing micro-sized 45S5 particles effectively occlude open dentinal tubules, providing immediate and lasting relief from sensitivity.
• Restorative Composites: Added to resin-based composites, the powder enhances bonding to tooth structure and releases ions that promote remineralization of adjacent enamel.
• Periodontal Therapy: Used as a grafting material in periodontal surgery to regenerate lost alveolar bone around teeth.

3. Wound Healing and Dermatology

Recent advancements have expanded the use of 45S5 powder into wound care. When applied to chronic wounds, such as diabetic ulcers, the glass particles interact with wound exudate to release therapeutic ions. These ions possess angiogenic properties, stimulating the formation of new blood vessels and accelerating tissue repair. Additionally, the alkaline environment created by ion exchange exhibits mild antibacterial effects, reducing the risk of infection.

4. Drug Delivery Systems

Researchers are increasingly utilizing 45S5 powder as a carrier for controlled drug delivery. The porous structure of bioactive glass can be loaded with antibiotics, growth factors, or anti-inflammatory agents. As the glass dissolves in the physiological environment, it releases these therapeutic agents in a sustained manner, targeting specific sites while simultaneously promoting tissue regeneration.

Why Choose Jinan Meiyi Biotechnology?

In a market with varying quality standards, selecting the right supplier is critical for product success. Our manufacturing philosophy centers on precision, purity, and partnership. Here is why leading medical device companies and research institutions choose our 45S5 powder.

Unmatched Chemical Precision

Bioactivity is highly sensitive to compositional changes. A deviation of even 1% in silica content can shift the material from bioactive to bio-inert. Our automated batching systems and real-time spectral analysis ensure that every kilogram of powder matches the exact 45S5 stoichiometry required for optimal performance.

Customizable Particle Engineering

We understand that one size does not fit all. Whether you need nano-particles for injectable hydrogels or coarse granules for 3D-printed scaffolds, our milling technology allows for precise control over particle size distribution. We can tailor the D10, D50, and D90 values to match your specific processing requirements.

Regulatory Support and Documentation

For medical device manufacturers, regulatory compliance is paramount. We provide comprehensive documentation packages, including Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and detailed technical dossiers supporting ISO 13485 quality management standards. This transparency accelerates your own regulatory submission processes.

Competitive Wholesale Pricing

By optimizing our supply chain and scaling production efficiency, we offer competitive wholesale prices without compromising quality. We support both small-scale R&D orders and large-volume industrial contracts, providing flexible pricing tiers that grow with your business.

Comparison: 45S5 vs. Other Bioactive Materials

Understanding how 45S5 compares to other biomaterials helps in making informed selection decisions for specific applications. The following table highlights key differences between 45S5 bioactive glass, hydroxyapatite (HA), and bioinert ceramics like alumina.

This comparison illustrates why 45S5 is often preferred for applications requiring rapid integration and biological activation, whereas inert ceramics are reserved for high-load-bearing joints where stability is the primary concern.

How to Select the Right Grade for Your Application

Choosing the correct specification of 45S5 powder involves balancing bioactivity, mechanical properties, and processing constraints. Here is a guide to help you determine the best fit for your project.

Consider Particle Size Distribution

For polymer composites, finer particles (1–5 µm) are recommended to ensure uniform dispersion and maintain the mechanical integrity of the polymer matrix. Larger particles can act as stress concentrators, leading to premature failure.

For scaffolds and bone cements, a broader distribution or larger granules (100–300 µm) may be beneficial to create porosity, which allows for vascular ingrowth and nutrient transport.

Evaluate Purity Requirements

If your application involves injectables or direct contact with sensitive tissues, opt for our ultra-high purity grade with stringent heavy metal limits. For external wound care products or non-implantable devices, standard medical grade powder provides a cost-effective solution without compromising safety.

Assess Processing Compatibility

Consider how the powder will be processed. If you are using 3D printing technologies like stereolithography (SLA), the powder must be compatible with the resin system and have low light scattering properties. For melt-quenching or sintering, thermal stability and particle packing density are key factors.

Storage and Handling Guidelines

Proper storage is essential to maintain the quality and bioactivity of 45S5 powder. Due to its high reactivity, the material is hygroscopic and can degrade if exposed to moisture.

• Keep Dry: Store in a cool, dry place with relative humidity below 50%. Always reseal containers immediately after use.
• Avoid Contamination: Use clean, non-metallic tools when handling the powder to prevent introduction of impurities.
• Temperature Control: Maintain storage temperatures between 15°C and 25°C. Extreme temperatures can affect particle surface energy.
• Safety Precautions: Although biocompatible, fine glass dust can irritate the respiratory tract. Wear appropriate personal protective equipment (PPE), including N95 masks and gloves, during handling.

Frequently Asked Questions (FAQ)

Is 45S5 Bioactive Glass Powder safe for human use?

Yes, 45S5 bioactive glass has an extensive history of clinical use and is widely recognized as biocompatible and safe. It has been used in thousands of surgical procedures worldwide for bone regeneration and dental applications. However, as with any medical material, it must be processed and sterilized according to relevant regulatory guidelines before implantation.

What is the shelf life of the powder?

When stored in original, unopened, vacuum-sealed packaging under recommended conditions, the shelf life of 45S5 powder is typically 24 months. Once opened, it should be used within 6 months and kept in a desiccator to prevent moisture absorption, which can prematurely initiate surface reactions.

Can you provide custom packaging for wholesale orders?

Yes, we offer flexible packaging options to suit your logistics and production needs. Standard packaging includes 1kg, 5kg, and 25kg moisture-proof bags. For large-scale industrial clients, we can provide custom drum sizes or bulk containers with specialized lining to ensure product integrity during transit.

Does the powder require sterilization before use?

Yes, for any implantable or invasive medical application, sterilization is mandatory. 45S5 powder can be sterilized using gamma irradiation or ethylene oxide (EtO) gas. Autoclaving (steam sterilization) is generally not recommended for fine powders as it can cause agglomeration and premature hydration. We can discuss sterilization protocols tailored to your specific manufacturing workflow.

How does particle size affect the price?

Pricing varies based on the complexity of the milling process. Nano-sized powders require more energy-intensive processing and stricter quality control, resulting in a higher cost per kilogram compared to micro-sized or granular grades. We provide transparent wholesale pricing structures based on volume and specification complexity.

What is the minimum order quantity (MOQ)?

We support clients at all stages of development. For R&D purposes, we offer small quantities starting from 100 grams. For commercial production, our wholesale MOQ typically starts at 25 kg, with significant price breaks available for orders exceeding 100 kg or 1 ton.

Industry Trends and Future Outlook

The market for bioactive materials is evolving rapidly. In 2026, we observe a growing trend towards multifunctional biomaterials. Researchers are no longer just looking for bone bonding; they demand materials that can deliver drugs, combat infection, and stimulate angiogenesis simultaneously. 45S5 powder is at the forefront of this innovation.

Another significant trend is the integration of bioactive glass into 3D bioprinting. The ability to print patient-specific scaffolds using bioactive glass-infused bio-inks is revolutionizing personalized medicine. Our finely tuned powder grades are specifically optimized for these advanced manufacturing techniques, ensuring smooth extrusion and high-resolution printing.

Furthermore, sustainability is becoming a key consideration. Our manufacturing processes are designed to minimize waste and energy consumption, aligning with the global push for greener medical supply chains.

Conclusion: Partner with a Trusted Supplier

Selecting the right source for 45S5 Bioactive Glass Powder is a strategic decision that impacts the quality, efficacy, and regulatory success of your final product. With our commitment to chemical precision, customizable particle engineering, and rigorous quality control, Jinan Meiyi Biotechnology Co., Ltd. provides the reliable foundation your innovations need.

Whether you are developing next-generation orthopedic implants, advanced dental composites, or novel wound care solutions, our high-purity 45S5 powder delivers the consistent bioactivity required for clinical success. We are not just a supplier; we are a technical partner dedicated to supporting your R&D and production goals through scientific rigor and market responsiveness.

Ready to Elevate Your Product Formulation?

Experience the difference of premium-grade bioactive glass. Contact our technical sales team today to request a sample, discuss your specific particle size requirements, or receive a customized wholesale quote.

Take the next step in biomaterial innovation:

• Request a free technical datasheet and CoA sample.
• Consult with our engineers on optimal powder specifications for your application.
• Secure competitive wholesale pricing for long-term supply agreements.

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