
2026-09-30 IB
Raws li daim ntawv pov thawj Kev kho mob qib 45S5 bioglass tsum, peb muab high-purity bioactive iav hmoov thiab granules engineered rau regenerative tshuaj, orthopedic implants, thiab kho hniav daim ntaub ntawv. Peb cov koom tes tsim khoom ISO-certified kom nruj ua raws li ASTM F1538 cov qauv, xa cov khoom me me sib xws, tswj crystallinity, thiab superior osteoconductivity. Peb txhawb pab pawg R & D thiab cov chaw tsim khoom siv kho mob nrog kev sib xyaw ua ke, tsim kom muaj peev xwm, thiab cov ntaub ntawv qhia txog kev tswj hwm kev xa tawm.
45S5 Bioglass, Ameslikas tsim los ntawm xibfwb Larry Hench ntawm University of Florida, sawv cev rau thawj cov khoom siv hluavtaws muaj peev xwm sib txuas ncaj qha rau cov pob txha nyob. Lub npe "45S5" yog hais txog nws cov muaj pes tsawg leeg: 45% silica (SiO2thiab 5: 1 molar ratio ntawm calcium rau phosphorus. Qhov no stoichiometry meej yog qhov tseem ceeb rau kev ua rau cov lus teb lom neeg xav tau rau osseointegration.
Tsis zoo li inert biomaterials xws li titanium los yog alumina, uas tso siab rau txhua yam fixation, 45S5 bioglass yog bioactive. Thaum raug cov kua dej physiological, nws dhau los ua cov tshuaj tiv thaiv saum npoo uas ua rau tsim cov hydroxycarbonate apatite (HCA) txheej. HCA txheej no yog tshuaj lom neeg thiab cov qauv zoo ib yam li cov ntxhia theem ntawm tib neeg cov pob txha, tso cai rau kev sib txuas tshuaj muaj zog es tsis yog kev cuam tshuam ntawm lub cev.
Cov txheej txheem ntawm kev txiav txim rau kev kho mob qib 45S5 bioglass muaj plaub theem sib txawv uas tshwm sim sai tom qab cog. Kev nkag siab txog cov theem no yog qhov tseem ceeb rau cov kws tsim khoom thiab cov kws kho mob xaiv cov khoom siv rau cov pob txha pob txha.
Qhov no feem ntau tshwm sim nyob rau hauv feeb mus rau teev tom qab cog. Qhov ceev thiab kev ua tau zoo ntawm cov txheej txheem no yog nyob ntawm qhov purity ntawm cov khoom siv raw thiab qhov sib xws ntawm cov txheej txheem tsim khoom, uas yog vim li cas thiaj li nrhiav tau los ntawm kev txhim khu kev qha. Kev kho mob qib 45S5 bioglass tsum yog qhov tseem ceeb.

Hauv kev lag luam khoom siv kho mob, cov khoom sib xws tsis yog ib qho kev ntsuas zoo xwb; nws yog ib qho kev cai lij choj. Kev hloov pauv hauv qhov loj me, cov kab tsis huv, lossis cov ntsiab lus crystalline tuaj yeem hloov pauv tus nqi degradation thiab cov lus teb lom neeg ntawm qhov cog. Lub tuam txhab ISO-certified muab cov txheej txheem tsim nyog los tswj cov kev hloov pauv no nruj me ntsis.
Cov ntaub ntawv kho mob yuav tsum ua raws li cov qauv thoob ntiaj teb nruj. Raws li tus neeg muag khoom tshwj xeeb, peb cov txheej txheem tsim khoom tau ua raws li:
Traceability txuas los ntawm cov hmoov oxide nyoos mus rau qhov kawg ntim khoom. Txhua batch yog muab ib tug tshwj xeeb ntau naj npawb, tso cai rau kom tiav reconstruction ntawm ntau lawm keeb kwm. Cov ntaub ntawv qib no yog qhov tseem ceeb rau cov neeg siv khoom nrhiav FDA tshem tawm lossis CE cim rau lawv cov cuab yeej kho mob zaum kawg.
Lub synthesis ntawm 45S5 bioglass yuav tsum tau tswj qhov kub thiab txias thiab huab cua tswj. Kev kis kab mob los ntawm cov khoom siv crucible lossis cov pa cua hauv huab cua tuaj yeem qhia cov impurities uas cuam tshuam txog bioactivity. Peb cov chaw koom tes siv cov platinum-lined furnaces thiab huv-chav ntim ib puag ncig kom txo qis kev pheej hmoo kis kab mob. Kev sib xyaw tshuab ua kom muaj kev sib xyaw ua ke ntawm qhov pib oxide sib xyaw, tiv thaiv kev sib xyaw ntawm cov gradients uas tuaj yeem ua rau qhov tsis sib xws ntawm kev sib cais.
Headquartered nyob rau hauv Jinan, Shandong xeev, Suav teb, Jinan Meiyi Biotechnology Co., Ltd. ua hauj lwm raws li ib tug subsidiary ntawm Pacific Kangtai Scientific Instruments (Jinan) Co., Ltd. Peb yog cov kws tshaj lij kev lag luam mob siab rau kev tshawb fawb, kev txhawb nqa, thiab kev lag luam ntawm bioactive technologies. Thaum peb cov hauv paus hniav tau nkag siab tob rau hauv cov tshuaj pleev ib ce thiab kev kho mob kom zoo nkauj, peb txoj kev mob siab rau kev tshawb fawb nruj thiab cov ntaub ntawv ua haujlwm siab txuas ntxiv mus rau thaj tsam ntawm cov tshuaj kho dua tshiab.
Nws yog ib qho tseem ceeb kom paub meej txog peb cov qauv kev ua haujlwm: Jinan Meiyi Biotechnology tsis koom nrog kev tsim khoom ncaj qha ntawm cov khoom siv raw. Hloov chaw, peb ua haujlwm raws li kev tsim khoom lag luam thiab cov khoom lag luam muaj txiaj ntsig zoo. Peb leverage ib tug zoo-tsim ntiaj teb no saw saw hlau network kom muaj kev koom tes nyob rau hauv lub sij hawm ntev kev sib raug zoo nrog thoob ntiaj teb lees paub, ISO-certified manufacturers. Qhov no tso cai rau peb los ua ib tus neeg ntseeg siab rau kev tsim kho tshiab, kom ntseeg tau tias peb cov neeg siv khoom hauv R & D lub chaw soj nstuam, CDMOs, thiab cov chaw kho kom zoo nkauj muaj kev nkag mus tau zoo ib yam rau cov txheej txheem thev naus laus zis, kev tswj hwm kev tswj hwm, thiab cov ntaub ntawv pov thawj tshawb fawb.
Peb lub hauv paus kev lees paub zoo yog qhov chaw nyob ntawm cov khoom tsim nyog tsim nyog, cov ntaub ntawv taug qab, thiab kev txheeb xyuas cov txheej txheem tshwj xeeb. Txhua chav tsev ntawm 45S5 bioglass peb faib yog nrog rau tag nrho cov ntaub ntawv qhia, suav nrog daim ntawv pov thawj ntawm kev tsom xam (CoA), cov ntaub ntawv kev nyab xeeb, thiab cov ntsiab lus ntawm kev tswj hwm. Los ntawm qhov tseem ceeb ntawm kev ntseeg siab, pob tshab, thiab kev ua haujlwm, peb txo cov khoom tsis yooj yim rau peb cov neeg siv khoom thaum muaj kev ntseeg siab tag nrho hauv cov khoom sib xws thiab kev tswj hwm kev npaj.
Peb muab kev kho mob qib 45S5 bioglass nyob rau hauv ntau hom ntawv kom haum raws li cov kev cai sib txawv. Lub cev daim ntawv ntawm bioglass cuam tshuam nws cov yam ntxwv tuav, tus nqi degradation, thiab txhua yam khoom hauv cov qauv sib xyaw.
Bioactive iav hmoov yog daim ntawv siv ntau tshaj plaws hauv cov pob txha hloov pauv, kho hniav, thiab txheej txheej txheej. Peb cov hmoov yog tus cwj pwm los ntawm nruj particle loj distributions kom paub tseeb tias flowability thiab reactivity.
| Parameter | Specification Range | Txoj Kev Xeem |
|---|---|---|
| Tshuaj muaj pes tsawg leeg | 45% SIb2, 24.5% Na2O, 24.5% CaO, 6% P2O5 (wt%) | XRF / ICP-OES |
| Particle Loj (D50) | Customizable: 1µm - 150µm | Laser Diffraction |
| Crystallinity | ≤ 5% (Amorphous qauv nyiam) | XRD |
| Hnyav Hlau | Tag nrho <10 ppm | ICP-MS |
| Endotoxin Qib | <0.5 EU / ml | LAL Test |
Lub amorphous xwm ntawm iav yog qhov tseem ceeb. Cov theem crystalline, xws li combeite lossis wollastonite, daim ntawv yog tias cov yaj yog txias qeeb dhau los yog yog tias lub iav raug kho cua sov tsis raug. Cov theem crystalline no tsawg dua bioactive thiab tuaj yeem yaj ntawm cov nqi sib txawv, ua rau cov txiaj ntsig tsis tuaj yeem tshwm sim. Peb cov txheej txheem quenching ceev ceev kom cov iav tseem muaj feem ntau amorphous.
Rau cov ntawv thov xav tau qhov chaw tu thiab vascular ingrowth, peb muab sintered granules thiab ntxeem tau scaffolds. Cov qauv no yog engineered los sib npaug txhua yam kev ncaj ncees nrog porosity.
Lub versatility ntawm 45S5 bioglass tau coj mus rau nws txoj kev saws los ntawm ntau yam kev qhuab qhia kho mob. Nws lub peev xwm los txhawb osteogenesis thiab angiogenesis ua rau nws haum rau ob qho tib si tawv thiab mos kho cov ntaub so ntswg.
Hauv kev phais orthopedic, 45S5 bioglass yog siv los ua cov pob txha tsis muaj qhov muab tub lim thiab txuas ntxiv. Nws yog feem ntau tov nrog autograft los yog allograft pob txha los txhim kho lub peev xwm osteoinductive ntawm graft. Nyob rau hauv cov txheej txheem fusion ntawm tus txha caj qaum, bioglass hais tau muab tso rau hauv cov khoom siv polymer los tsim cov tawb sib xyaw uas txhawb nqa kev sib koom ua ke ntawm vertebral.
Kev tso tawm ntawm cov hom silicon soluble los ntawm cov iav dissolving tau pom tias upregulate gene qhia txog cov pob txha tsim. Tshwj xeeb, silicon ions txhawb nqa osteoblast proliferation thiab sib txawv, ua kom cov txheej txheem kho. Qhov kev txhawb nqa lom neeg no yog qhov txiaj ntsig tseem ceeb ntawm cov khoom siv tsis zoo xws li polymethylmethacrylate (PMMA).
Kev kho hniav sawv cev rau ib qho kev lag luam loj tshaj plaws rau cov iav bioactive. Cov ntawv thov suav nrog:
Kev tshawb fawb tsis ntev los no tau nthuav dav daim ntawv thov ntawm 45S5 bioglass rau kho cov nqaij mos. Cov ionic dissolution cov khoom txhawb nqa fibroblast proliferation thiab collagen ntau lawm. Hauv kev saib xyuas qhov txhab mob ntev, kev hnav khaub ncaws bioglass pab tswj exudate thaum txhawb kev tsim cov ntaub so ntswg granulation. Lub alkaline ib puag ncig tsim los ntawm kev sib pauv ion kuj nthuav tawm cov tshuaj tua kab mob me me, txo qhov kev pheej hmoo ntawm kev kis kab mob hauv cov qhov txhab tsis zoo.

Xaiv qhov zoo biomaterial yuav tsum muaj kev nkag siab meej txog yuav ua li cas 45S5 bioglass piv rau lwm cov kev xaiv uas nquag siv. Cov lus hauv qab no qhia txog qhov sib txawv tseem ceeb ntawm bioactivity, mechanical zog, thiab kev kho mob.
| Feature | 45 S5 Bioglass | Hydroxyapatite (HA) | Beta-Tricalcium Phosphate (β-TCP) | Inert Polymers (PEEK / PMMA) |
|---|---|---|---|---|
| Bioactivity | High (Txoj Kev Sib Txuas Lus Index A) | Nruab nrab (Osteoconductive) | Nruab nrab (Osteoconductive) | Tsis muaj (Bioinert) |
| Bonding Mechanism | Chemical Bond (HCA Txheej) | Kev sib xyaw ua ke saum npoo | Kev sib xyaw ua ke saum npoo | Mechanical Interlock |
| Tus nqi degradation | Tswj Dissolution | Yooj yim heev | Nruab nrab mus nrawm | Tsis-degradable |
| Osteostimulation | Yog (Gene Upregulation) | Tsis muaj | Tsis muaj | Tsis muaj |
| Mechanical Strength | Brittle (Low Tensile) | Brittle (High Compressive) | Brittle (Low Compressive) | Siab Toughness |
| Thawj Siv Case | Pob txha Regeneration/Coatings | Pob txha Void Filler | Resorbable Scaffold | Cov qauv kev cog hniav |
Thaum hydroxyapatite thiab TCP yog cov khoom siv osteoconductive zoo heev, lawv tsis muaj osteostimulatory zog ntawm 45S5 bioglass. Lawv ua hauj lwm feem ntau yog passive scaffolds rau pob txha ingrowth. Hauv qhov sib piv, 45S5 nquag qhia cov hlwb kom pib tsim cov pob txha. Txawm li cas los xij, bioglass yog nkig thiab tsis tuaj yeem dais ntawm nws tus kheej. Yog li ntawd, nws feem ntau ua ke nrog cov polymers lossis hlau hauv cov qauv sib xyaw kom ua tiav qhov tsim nyog txhua yam kev ua haujlwm rau kev siv cov khoom siv thauj khoom.
Kev xaiv cov khoom tsim nyog 45S5 bioglass nyob ntawm ntau yam, suav nrog cov ntawv thov, kev ua, thiab kev tswj hwm txoj hauv kev. Raws li koj Kev kho mob qib 45S5 bioglass tsum, peb pom zoo kom xav txog cov kev txwv hauv qab no thaum lub sijhawm xaiv.
Qhov loj me me txiav txim siab thaj tsam ntawm thaj chaw muaj rau cov tshuaj tiv thaiv thiab tuav cov khoom ntawm cov khoom.
Rau kev siv kho mob, purity yog tsis-negotiable. Xyuas kom meej tias tus neeg muag khoom muab daim ntawv pov thawj ntawm kev soj ntsuam (CoA) nthuav dav cov ntsiab lus ntawm cov hlau. Hlau, txhuas, thiab lwm yam hlau hloov pauv tuaj yeem ua rau cov kev xav tsis zoo los yog ua rau cytotoxicity. Peb cov ntaub ntawv kho mob tau lees paub cov qib qis ntawm cov impurities no, txheeb xyuas los ntawm ICP-MS tsom xam.
Nyob ntawm koj cov txheej txheem tsim khoom, koj yuav xav tau cov khoom tsis muaj menyuam lossis tsis muaj menyuam. Yog tias koj ua qhov kev ua kom tsis muaj menyuam ntawm koj lub cuab yeej zaum kawg, cov khoom siv bioglass uas tsis muaj menyuam tsis taus hauv cov hnab ntim khoom huv, chav tsev yuav txaus. Txawm li cas los xij, yog tias bioglass tau muab tso rau hauv cov khoom uas tsis tuaj yeem ua kom tsis muaj menyuam tom qab sib dhos, yuav tsum muaj gamma-irradiated lossis aseptic-filled bioglass. Nco ntsoov tias gamma irradiation qee zaum tuaj yeem cuam tshuam rau qhov chaw chemistry ntawm cov iav, yog li kev tshawb fawb siv tau yog tsim nyog.
Tus neeg muag khoom muaj npe nrov yuav tsum muab cov ntaub ntawv qhia ntxaws los txhawb koj cov ntaub ntawv tswj hwm. Qhov no suav nrog:
Muaj kev nkag mus rau cov ntaub ntawv no thaum ntxov hauv theem kev txhim kho tuaj yeem ua kom koj lub sijhawm mus rau kev lag luam.
Kev tuav ntawm 45S5 bioglass yog qhov tseem ceeb los tswj nws cov bioactivity thiab ua kom cov neeg ua haujlwm muaj kev nyab xeeb. Txawm hais tias bioglass yog biocompatible, hmoov zoo tuaj yeem ua rau cov neeg kho tshuab ua pa yog tias nqus tau.
45S5 bioglass yog hygroscopic rau qee qhov. Kev raug dej noo tuaj yeem ua rau muaj qhov tshwm sim ntxov ntxov, ua rau agglomeration thiab txo lub neej txee. Khaws cov khoom nyob rau hauv qhov chaw txias, qhuav, qhov zoo tshaj plaws nyob rau hauv desiccated ntim. Thaum qhib, siv cov khoom tam sim ntawd los yog rov ua kom nruj nrog cov khoom desiccant. Tsis txhob cia lub sijhawm ntev hauv qhov chaw ntub dej.
Thaum koom nrog bioglass rau hauv polymer matrices (piv txwv li, PCL, PLGA, PEKK), xyuas kom meej dispersion los tiv thaiv pawg. Agglomerates tuaj yeem ua raws li kev ntxhov siab concentrators, ua kom tsis muaj zog ntawm cov khoom sib xyaw. Siv surfactants los yog coupling agents yog tias tsim nyog los txhim kho qhov sib cuam tshuam ntawm cov iav thiab cov polymer. Thaum lub sij hawm ua, khaws cia kub hauv qab lub crystallization pib ntawm lub khob (feem ntau nyob ib ncig ntawm 600-700 ° C) kom tswj nws cov qauv amorphous.
Ib txwm hnav cov cuab yeej tiv thaiv tus kheej tsim nyog (PPE) thaum tuav cov hmoov bioglass, suav nrog N95 qhov ncauj qhov ntswg, hnab looj tes, thiab looj tsom iav dub. Ua hauj lwm hauv qhov chaw fume hood los yog qhov chaw muaj cua zoo kom txo tau cov plua plav tawm. Txawm hais tias cov khoom tsis muaj tshuaj lom, yuav tsum zam qhov nqus ntawm cov khoom me me.
45S5 yog thawj bioactive iav muaj pes tsawg leeg nrog lub siab tshaj plaws bioactivity Performance index. Lwm cov khoom sib xyaw, xws li 13-93 lossis borate-based tsom iav, muaj qhov sib txawv ntawm qhov sib txawv thiab cov khoom siv tshuab. 45S5 yog qhov zoo dua rau cov ntawv thov uas xav tau ceev cov pob txha sib txuas thiab osteostimulation.
Yog lawm, 45S5 bioglass yog bioresorbable. Nws dissolves maj mam li cov pob txha tshiab cov ntaub ntawv, nws thiaj li raug hloov los ntawm tej pob txha. Tus nqi ntawm resorption tuaj yeem hloov kho los ntawm kev kho qhov me me thiab qhov porosity.
Ntshiab 45S5 bioglass yog nkig thiab tsis haum rau kev siv cov khoom siv thauj khoom ib leeg. Txawm li cas los xij, nws tau siv dav hauv cov ntaub ntawv sib xyaw nrog cov polymers lossis hlau, qhov chaw matrix muab cov khoom siv dag zog thiab bioglass muab bioactivity.
Qhov me me me me muaj qhov loj dua ntawm thaj tsam-rau-ntim piv, ua rau kom nrawm dua ion pauv thiab HCA txheej txheej. Txawm li cas los xij, cov khoom zoo heev tuaj yeem hnov mob sai heev, ua rau lub pH ntse ntse uas tuaj yeem ua rau cov hlwb nyob ib puag ncig. Optimal particle loj nyob ntawm qhov kev thov kho mob tshwj xeeb.
Peb cov koom tes koom tes yog ISO 13485 ntawv pov thawj rau kev tsim khoom siv kho mob. Peb ua raws li ASTM F1538 tus qauv rau bioactive iav characterization thiab muab tag nrho cov ntaub ntawv rau ISO 10993 biocompatibility yuav tsum.
Yog lawm, los ntawm peb cov kev sib koom tes tsim kev lag luam, peb muab cov kev pabcuam sib xyaw ua ke rau cov khoom sib xyaw tshwj xeeb lossis cov khoom loj me me. Peb pab neeg ua haujlwm tuaj yeem ua haujlwm nrog koj los tsim cov kev daws teeb meem rau cov kev xav tau tshwj xeeb.
Ib qho tshwj xeeb ntawm 45S5 bioglass yog tso tawm ntawm silicon soluble (silicic acid) thaum lub sij hawm tawg. Silicon yog ib qho tseem ceeb kab nyob rau hauv tib neeg biology, ua lub luag haujlwm tseem ceeb hauv cov pob txha mineralization thiab collagen synthesis. Cov kev tshawb fawb tau pom tias silicic acid txhawb osteoblasts los tsim cov qib siab dua ntawm alkaline phosphatase thiab osteocalcin, cov cim ntawm cov pob txha tsim.
Tsis tas li ntawd, silicon ions tau pom los txhawb angiogenesis, tsim cov hlab ntsha tshiab. Kev txaus vascularization yog qhov tseem ceeb rau kev ciaj sia ntawm cov pob txha tshiab. Los ntawm kev muab kev tso tawm ntawm silicon, 45S5 bioglass tsim ib qho chaw zoo microenvironment rau cov pob txha thiab cov hlab ntsha loj hlob, txhim kho tag nrho cov kev vam meej ntawm cov txheej txheem regenerative.
Lub teb ntawm bioactive iav yog evolving sai heev. Kev tshawb fawb tam sim no tsom mus rau doping 45S5 nrog kev kho mob ions xws li strontium, magnesium, zinc, thiab tooj liab. Cov dopants no tuaj yeem muab cov haujlwm ua haujlwm ntxiv, xws li kev ua haujlwm tiv thaiv kab mob, tshuaj tiv thaiv kab mob, lossis txhim kho osteogenesis.
Lwm qhov kev tshwm sim yog kev txhim kho ntawm 45S5-based nanofibers thiab cov qauv mesoporous. Cov architectures siab heev no muab cov cheeb tsam siab dua thiab muaj peev xwm thauj khoom thiab xa cov tshuaj lossis kev loj hlob hauv kev tswj hwm. Raws li kev xav rau pem hauv ntej Kev kho mob qib 45S5 bioglass tsum, Jinan Meiyi Biotechnology nquag saib xyuas cov qauv no thiab nqis peev hauv R & D kev sib koom tes los txhawb cov ntawv thov lwm tiam.
Kev xaiv tus khub cov ntaub ntawv raug yog qhov kev txiav txim siab zoo uas cuam tshuam rau qhov zoo, kev nyab xeeb, thiab kev ua tau zoo ntawm koj cov cuab yeej kho mob. Ntawm Jinan Meiyi Biotechnology Co., Ltd., peb muab cov kws tshaj lij kev tshawb fawb nrog cov khoom lag luam zoo, muaj kev lees paub zoo los xa cov khoom lag luam uas ua tau raws li cov qauv kev lag luam siab tshaj plaws. Peb cov txheej txheem kev tswj hwm kev tswj hwm, kev tswj xyuas kom zoo, thiab kev txhawb nqa kev ua tiav kom ntseeg tau tias koj tau txais kev ua tau zoo, ua tau zoo bioglass rau koj daim ntawv thov.
Txawm hais tias koj tab tom tsim cov pob txha tshiab hloov pauv, kho hniav txheej txheej, lossis hnav khaub ncaws tu lub qhov txhab, peb 45S5 bioglass muab cov bioactivity thiab kev ntseeg siab xav tau rau kev kho mob kom zoo. Peb nkag siab txog qhov nyuaj ntawm kev ua raws li txoj cai thiab tau cog lus los txhawb koj thoob plaws hauv kev txhim kho cov khoom lag luam nrog cov qauv kev pabcuam kev koom tes.
Yog tias koj tab tom nrhiav rau qhov chaw cia siab rau kev kho mob qib 45S5 bioglass, tiv tauj peb pab neeg ua haujlwm hnub no. Peb muab cov khoom siv coj mus kuaj, cov lus hais txog kev cai, thiab cov lus qhia ntxaws ntxaws los pab koj xaiv cov khoom siv zoo rau koj cov kev xav tau.