Recombinant human superoxide dismutase (rhSOD): Ọhụụ ọhụrụ n'ọhịa nke antioxidants nyere ikike biotechnology. 

Ahụ anyị na-emepụta superoxide dismutase (SOD), mana ọtụtụ ihe ịma aka nke ndụ ọgbara ọhụrụ karịrị ike ya. Ịgbakwunye SOD abụghị naanị uru agbakwunyere, kama ọ bụ nkwado dị mkpa maka ahụ. Nhọrọ nke mgbakwunye SOD, Otú ọ dị, na-ekpebi arụmọrụ na nchekwa nke nkwado a.

Tupu anyị atụle "ihe a ga-agbakwunye," anyị ga-ebu ụzọ ghọta "ihe mere anyị ji kwesị ịgbakwunye." Nke a abụghị naanị maka ịma mma, kamakwa banyere ụkpụrụ isi nke ahụike.

Kedu ihe kpatara o ji dị mkpa ịgbakwunye na superoxide dismutase (SOD)?

Ahụ mmadụ nwere n'ezie "usoro mmepụta SOD" nke ya, mana na afọ na mgbanwe n'ụdị ndụ ya, "ntụziaka ntinye ego" nke SOD ji nwayọọ nwayọọ na-akụda, na-eduga n'ịfe oke nke radicals free, na-emebi ọrụ anụ ahụ ma na-eme ka usoro ịka nká dịkwuo elu.

1.Ịka nká:  SOD nke ahụ nke ya “mpụta na-ebelata,” na ikike ịchụpụ ya na-adị oke.

Afọ 25 bụ isi ihe dị mkpa: Tupu afọ 25, ọnụ ọgụgụ ahụ nke njikọ SOD nwere ike ịdị mfe "na-aga n'ihu" na ọnụego nke mmepụta free radical; Otú ọ dị, mgbe afọ 25 gasịrị, njikọ SOD na-ebelata na ọnụego 1%-2% kwa afọ. Ka ọ na-erule afọ 40, ọrụ SOD nke anụ ahụ bụ naanị 50% nke ọkwa ya kacha elu, ma mgbe afọ 60 gasịrị, ọ na-erughị 30%.

Ka ọ dị ugbu a, mmepụta nke free radicals anaghị ebelata-mkpụrụ ndụ cell na iku ume na-anọgide na-emepụta superoxide anion free radicals. Nke a na-eduga na ezughị ezu SOD, na ngafe free radicals na-amalite ịwakpo mkpụrụ ndụ: na-emebi akpụkpọ collagen (na-akpata wrinkles), na-emebi vaskụla endothelium (ịme ngwa ngwa vaskụla ịka nká), na oxidizing imeju mkpụrụ ndụ (na-abawanye metabolic ibu). Nke a bụ otu n'ime isi ihe kpatara "ịka nká."

2.Modern Life: Excess Free Radicals, ezughị ezu Endogenous SOD

E wezụga afọ, omume ndụ kwa ụbọchị na-emekwa ka mmepụta nke radicals efu ngwa ngwa:

Mkpughe UV: Ikpughe anyanwụ maka otu awa kwa ụbọchị na-abawanye radicals efu nke akpụkpọ ahụ na-emepụta ugboro atọ, karịa ikike ikpochapụ SOD (superoxide dismutase) nke anụ ahụ;

N'abalị na nchekasị: Mgbe ụra na-ehi ụra ma ọ bụ na-enwe nchekasị, ahụ na-ezobe "hormone nrụgide," na-akpali mmepụta nke ọnụ ọgụgụ dị ukwuu nke free radicals;

Nri na-adịghị mma: shuga dị elu, abụba dị elu, na nri e ghere eghe na-emepụta ngwaahịa njedebe glycation dị elu n'oge metabolism, tinyere ọnụ ọgụgụ dị ukwuu nke free radicals;

Mmetọ gburugburu ebe obibi: Ihe ndị na-emerụ ahụ na smog, iyuzucha ụgbọ ala, na anwụrụ ọkụ nke abụọ, mgbe ha banyere n'ime ahụ mmadụ, na-ebute "nrụgide oxidative," na-eduga n'ịbawanye nke free radicals;

Mmetụta ọrịa: Ọnọdụ pathological nke ọrịa na-akpata na usoro ọgwụgwọ ọgwụ na-eme ka nrụgide oxidative dịkwuo njọ n'ime ahụ, na-aghọ ihe ndị dị mkpa na-akpata mmụba na-adịghị mma nke free radicals.

3.The ahu onwe SOD nwere "oke ikike" na-apụghị ịnagide "mwakpo ndọkwasị."

Ọbụlagodi na ndị na-eto eto nwere ụdị ndụ ahụike, SOD nke anụ ahụ nwere oke ya: a na-etinyekarị ya n'ime sel ma na-enye mkpuchi ezughị oke megide radicals free n'ime ọbara na n'elu anụ ahụ; Ọzọkwa, ọrụ ya adịghị elu nke ọma iji kpochapụ free radicals n'ụzọ dị irè n'oge "mgbawa gbasasịrị" (dị ka mgbe anwụ gachara ma ọ bụ mmega ahụ siri ike).

Nke a bụ ebe ịgbakwunye SOD na-adị mkpa - ọ dị ka ịgbakwụnye "ndị na-ehicha nke ọma" na ahụ iji nyere aka wepụ ngwa ngwa radicals n'efu ma gbochie mmebi cell na-aga n'ihu.