Kedu ihe bụ PDRN kpọmkwem? Gịnị mere e ji too ya dị ka “isi ihe na-enye ọgwụ na-emeghachi omume”? 

N'ihe gbasara nlekọta anụ ahụ na ọgwụ ịchọ mma, "mmeghachite" bụ echiche na-adọrọ adọrọ. Mgbe akpụkpọ ahụ mebiri emebi ma ọ bụ mere agadi, anyị na-atụ anya ịkpọte ikike nrụzi eke. PDRN bụ kpọmkwem “igodo” nke ndị sayensị chọpụtara n'oge na-adịbeghị anya iji mee ka usoro nrụzi cellular rụọ ọrụ nke ọma. Taa, anyị ga-ekpughe ihe omimi ya.

Mmalite: mmụọ nsọ sitere na ike nrụpụta nke oke osimiri

PDRN (Polydeoxyribonucleotide), onye aha ya n'uju bụ polydeoxyribonucleotide, abụghị ngwaahịa ejiri kemịkal emepụta, kama nke sitere na mkpụrụ ndụ ọmụmụ salmon eke.

Ndị ọkà mmụta sayensị chọpụtara na salmon nwere ikike imegharị anụ ahụ siri ike na ịrụzi ya. Site na nyocha ọzọ, ha weputara iberibe DNA a kpọmkwem-PDRN-site na sperm salmon. DNA a yitere nke ukwuu n'ụdị nhazi ya na DNA nke anụmanụ niile (gụnyere mmadụ), na-egosipụta ezigbo bioacompatibility yana obere ihe ize ndụ nke ịjụ ọrịa ahụ, si otú a na-enye ohere maka ojiji dị mma na nke dị irè na ahụ mmadụ.

Isi ihe: Ọ bụghị naanị “ihe akụrụngwa,” kamakwa “ọkwa.”

Anyị nwere ike ịghọta usoro omume nke PDRN site n'akụkụ abụọ bụ isi:

Dị ka "ihe nrụzi": PDRN nwere ọtụtụ deoxyribonucleotides (nke bụ isi nke DNA). Mgbe anụ ahụ akpụkpọ ahụ mebiri emebi na mkpụrụ ndụ kwesịrị ikewa ma gbasaa iji rụchaa, nucleotides ndị a dị ngwa ngwa nwere ike iji mkpụrụ ndụ mee ihe dị ka ihe eji eme DNA ọhụrụ, si otú a na-eme ka usoro nhazi ahụ dịkwuo ngwa.

Dị ka “ihe mgbama nrụzi”: Nke a bụ usoro dị mkpa na pụrụ iche nke PDRN. Enwere ike ịmata PDRN kpọmkwem site na mkpụrụ ndụ gbara ya gburugburu mebiri emebi ma ọ bụ hypoxic anụ ahụ ma jikọta adenosine A2A ndị na-anabata ya n'elu cell, na-egbochi NF-kB na MAPK ụzọ mgbaàmà nke ROS na-arụ ọrụ.  Nke a na-ebelata mmepụta nke cytokines pro-inflammatory (IL-6, IL-1β, TNF-α, wdg) ma na-akwalite nkwupụta nke cytokines na-egbu egbu (IL-10), si otú ahụ na-eme ka ọ dị ike na-eme ihe na-adịghị mma.  Ọzọkwa, ọ na-akpali nzuzo nke EGF (epidermal growth factor), FGF (fibroblast growth factor), VEGF (vaskụla endothelial growth factor), na angiopoietin, na-enye PDRN magburu onwe mgbochi mkpali na ọnya ọgwụgwọ Njirimara.

Ọrụ isi: yinye nrụzi site na micro ruo ọkwa nnukwu.

Dabere na usoro akọwara n'elu, PDRN na-arụ usoro mmetụta dị mma jikọtara ọnụ na ọkwa akpụkpọ:

Na-akwalite angiogenesis: Na-abawanye ọbara na mpaghara mebiri emebi, na-ebutekwu oxygen na nri na-ewepụ ihe mkpofu nke metabolic.

Na-akwalite mmụba cell na ịkwaga: Na-eme ka ọrụ na ọnụ ọgụgụ nke mkpụrụ ndụ nrụzi isi dị ka fibroblasts na keratinocytes.

Na-akpali mmepụta nke collagen na elastin: na-eme ka akpụkpọ ahụ dị ike site na dermis, na-eme ka ahịrị dị mma na-abawanye ụba.

Mmetụta mgbochi mkpali dị ike: Na-eme ka mmeghachi omume mkpali dị ka ọbara ọbara, ọzịza, okpomọkụ na mgbu site n'ịhazi ihe ndị na-akpasu iwe.

Ndozi anụ ahụ na ọgwụgwọ ọnya:  Na-ejikọta mmetụta niile dị n'elu, ọ na-eme ka usoro ọgwụgwọ nke mmerụ ahụ dị iche iche dịkwuo ngwa ngwa.

A na-akpọ PDRN dị ka "igodo nke ịmaliteghachi" n'ihi na ọ bụghị naanị ịrụzi ma na-edozi ahụ, kama ọ na-achịkwa ọrụ cell.  Dabere na oke biocompatibility ya, ọ na-eme ka anụ ahụ nwee ike ịmaliteghachi site na mmetụta synergistic multi-pathway. Usoro a nke "ịkpọlite ​​ikike nrụzi ihe dị n'ime" bụ isi nchụso n'ọhịa nke ịmaliteghachi, ọ bụkwa ihe na-enye PDRN ọnọdụ ya enweghị ike dochie ya na ngalaba ahụike anụ ahụ.