Kugwirizana kwa Katswiri Pazachipatala Chogwiritsa Ntchito PDRN Acid Mu Dermatology 

M'zaka zaposachedwa, polydeoxyribonucleic acid (PDRN) yalandira chidwi ndikugwiritsa ntchito kwambiri pankhani ya dermatology, komabe pali kusamvetsetsana kogwirizana pankhani ya kuyimitsidwa kwa ntchito yake. Laser Cosmetology Group of the Chinese Medical Association’s Branch of Aesthetic and Plastic Surgeons and the Medical Cosmetology Group of the Chinese Association of Integrative Medicine mogwirizana adapereka "Consensus Expert on the Clinical Application of Polydeoxyribonucleic Acid in Dermatology," ndicholinga chopatsa asing'anga upangiri wasayansi ndi zolinga kuti awatsogolere pakugwiritsa ntchito PD PD.

Pharmacokinetics ndi Mechanism of Action ya PDRN

PDRN ilipo mu plasma mu mawonekedwe aulere ndipo sichimangirira ku plasma apolipoproteins. Kugawidwa kwake kumagwirizana bwino ndi kutuluka kwa magazi a minofu. Mankhwalawa samapangidwa ndi chiwindi; zimadetsedwa makamaka ndi plasma DNA nucleases kapena cell membrane nucleases kuti apange chogwiritsira ntchito, mononucleotide. Pamapeto pake, ambiri amatulutsidwa mumkodzo (pafupifupi 65%), ndikutulutsa pang'ono mu ndowe.

Kuwonongeka kwa PDRN kumapanga ma nucleotides ndi nucleosides, kupereka zipangizo zopangira DNA zowonongeka komanso kulimbikitsa mwamsanga kukonzanso DNA yowonongeka ndi kufalikira kwa maselo.

Clinical Application ya PDRN mu Dermatology

1. Kuchiritsa Mabala

Kafukufuku waposachedwa wapeza kuti PDRN imatenga nawo gawo pakuchiritsa mabala kuchokera kumakona angapo, kuphatikiza kuletsa mayankho ochulukirapo otupa, kufulumizitsa kukonzanso kwa epidermal ndi dermal, kulimbikitsa kuyika kwa collagen, ndikuwongolera angiogenesis ndi zinthu zina zowongolera monga VEGF. Mu autologous khungu kumezanitsa odwala, intramuscular, subcutaneous, kapena apakhungu PDRN jakisoni pamalo bala akhoza imathandizira bala re-epithelialization ndi machiritso nthawi. Komanso, PDRN ntchito pambuyo CO2 fractional laser mankhwala akhoza imathandizira bala machiritso; Choncho, PDRN akhoza kuganiziridwa pambuyo ablative laser mankhwala kulimbikitsa machiritso bala ndi kubwezeretsa khungu chotchinga ntchito.

2. Melasma ndi Post-kutupa Hyperpigmentation:

Zomwe zimayambitsa melasma ndi post-inflammatory hyperpigmentation makamaka zimaphatikizapo kuyambitsa kwachilendo kwa melanocyte ndi kuyankha kwa kutupa kosalekeza. PDRN imatha kuwongolera njira za kinase ndi protein kinase B poyambitsa ma sign a extracellular mu melanocytes, kuchepetsa kuchuluka kwa zinthu zolembera zokhudzana ndi angiotensin, kuletsa kufotokoza kwa mapuloteni okhudzana ndi tyrosinase ndi melanin, ndikuchepetsa kuchuluka kwa melanin mu melanocyte. Kachipatala, PDRN ikhoza kuganiziridwa mophatikizana ndi njira zina zochizira matenda amtundu wa refractory monga melasma kapena post-inflammatory hyperpigmentation. 3. Kukalamba Khungu:

PDRN imayendetsa adenosine A2A zolandilira kapena njira zopulumutsira, kuwongolera kuchuluka kwa cyclic adenosine monophosphate (cAMP), kuletsa MMPs ndi elastase secretion, kukonzanso matrix a extracellular, kumachepetsa makwinya, kukonzanso khungu, ndikuwongolera mawonekedwe a khungu. Kuphatikiza apo, kafukufuku wambiri apeza kuti PDRN imatha kuchepetsa kuchuluka kwa zinthu zosiyanasiyana zoyambitsa kutupa monga IL-6, IL-1β, TNF-α, ndi IL-12, ndikuwongolera kutulutsa kwazinthu zotupa monga IL-10. Izi zikuwonetsa kuti PDRN ikhoza kuchedwetsa nthawi imodzi kuchitika ndi kukula kwa kujambula kwa khungu poletsa katulutsidwe ka SASP, kuwongolera kuyanika kwa khungu, kuuma, ndi kukulitsa pores, ndikuchepetsa kutayika kwa madzi a transepidermal, motero kuthana ndi mavuto okalamba a khungu.

4. Kuwotcha:

Muchitsanzo cha machiritso a makoswe a SD, PDRN idapezeka kuti imachepetsa kulowetsedwa kwa cell yotupa m'minyewa yamabala komanso kuletsa kuchuluka kwa zipsera poletsa mawu a HMGB-1. Kafukufuku wachipatala wapadziko lonse apeza kuti kugwiritsa ntchito PDRN koyambirira pambuyo pa chithokomiro kungathe kusintha kwambiri maonekedwe, mtundu, ndi kukula kwa zipsera za hypertrophic, ndi chitetezo chabwino komanso popanda zovuta. Chifukwa chake, kulowererapo koyambirira ndi PDRN kungaganizidwe ngati mabala omwe ali pachiwopsezo chokhala ndi zipsera. Pakadali pano, palibe maphunziro okhudza mphamvu ya PDRN mu keloids.

5. Androgenetic alopecia:

Odwala ndi androgenetic alopecia amawonetsa kusintha kwa scalp monga kuchepetsedwa ndi mitsempha yamagazi. PDRN ikhoza kuyendetsa njira yowonetsera Wnt, kulimbikitsa kufalikira kwa tsitsi, ndikuwongolera VEGF ndi ma vasoactive agents, potero kumapangitsa kuti androgenetic alopecia. Kafukufuku woyembekezeredwa apeza kuti kwa odwala omwe ali ndi androgenetic alopecia omwe samayankha mankhwala ochiritsira ochiritsira, kugwiritsa ntchito PDRN pamodzi ndi PRP kapena 1927nm thulium fractional laser treatment kungakhale njira yotheka. Komabe, kukula kwachitsanzo kokulirapo kumafunikabe kuwunika chitetezo.

6. Matenda ena apakhungu:

Odwala ndi androgenetic alopecia amawonetsa kusintha kwa scalp monga kuchepetsedwa ndi mitsempha yamagazi. PDRN ikhoza kuyendetsa njira yowonetsera Wnt, kulimbikitsa kufalikira kwa tsitsi, ndikuwongolera VEGF ndi ma vasoactive agents, potero kumapangitsa kuti androgenetic alopecia. Kafukufuku waposachedwa wasonyeza kuti PDRN yophatikizidwa ndi PRP kapena 1927nm thulium fractional laser treatment ikhoza kukhala njira yabwino kwa odwala omwe ali ndi androgenetic alopecia omwe samayankha mankhwala ochiritsira. Komabe, zitsanzo zazikuluzikulu zimafunikirabe kuti zitsimikizire chitetezo chake.

Kugwiritsa Ntchito Kovomerezeka

Kugwiritsiridwa ntchito kwa PDRN kumasiyana mosiyanasiyana m'matenda osiyanasiyana, ndipo ndondomeko yogwiritsira ntchito yogwirizana ikusowabe.

Pakadali pano, zolemba zapakhomo ndi zapadziko lonse lapansi zimapereka malipoti a njira zoyendetsera PDRN kuphatikiza kugwiritsa ntchito topical, kutumiza kwa intradermal, jekeseni wa intradermal, jekeseni wa subcutaneous, ndi jakisoni wa intramuscular. Mafupipafupi a mlingo amayambira kamodzi patsiku mpaka kamodzi pamlungu, ndipo nthawi ya mlingo imachokera masiku angapo mpaka masabata angapo. Komabe, njira zenizeni zogwiritsira ntchito ziyenera kutsatiridwa mosamalitsa malinga ndi gulu la mankhwala (mankhwala kapena chipangizo chachipatala).

Chitetezo ndi Chitetezo

1. PDRN ili ndi chiyero cha DNA> 95% ndipo ilibe mapuloteni kapena ma peptide omwe amagwiritsira ntchito mankhwala, choncho chitetezo chake ndi chochepa.
2. Maphunziro angapo azachipatala adatsimikiziranso kuti PDRN ili ndi chitetezo chabwino komanso kulekerera mosasamala kanthu za njira yoyendetsera. Palibe zowopsa kapena zoyipa zazikulu zomwe zawonedwa pambuyo pakugwiritsa ntchito pamitu, ngakhale kuti nthawi zina zimakhala zofooka pang'ono monga kufiira pakhungu, kuyabwa, ndi kuluma. Zizindikirozi nthawi zambiri zimachepa msanga pambuyo posiya kumwa mankhwalawa kapena kulandira chithandizo chamankhwala.
3. Pali kuthekera kwa zochitika zoyipa monga ma granulomas akunja ndi matenda enaake pamene PDRN imayendetsedwa ndi jekeseni. Choncho, kusamala kuyenera kugwiritsidwa ntchito pogwiritsa ntchito mankhwalawa intradermally kapena subcutaneously.
4. PDRN imatsutsana ndi amayi apakati ndi oyamwitsa, omwe ali ndi mabala omwe ali ndi kachilombo, ndi omwe sali okhudzana ndi PDRN.

Chidule ndi Outlook

1. Ku China, PDRN imagwiritsidwa ntchito makamaka pamitu komanso kudzera mu microneedling mesotherapy. Popeza PDRN ili ndi zotsutsana ndi zotupa komanso kuthekera kokonzanso minofu, kafukufuku wamtsogolo angayang'ane zomwe zingachitike pakugwiritsa ntchito mwanzeru.
2. Kuphatikiza apo, njira zoyendetsera PDRN pochiza zovuta zosiyanasiyana zapakhungu, kuphatikiza kudziwa njira yabwino yoyendetsera, mafupipafupi, ndi kukhazikika, komanso zotsatira zake zogwirizana ndi njira zina zochiritsira, zimafunikira kufufuza kwina.