Salmon PDRN kuburuhu rwumva kandi rwangiritse: Igisubizo gishyigikiwe na siyanse yo gusana inzitizi no kugabanya umutuku 

Meta Ibisobanuro:
Wige uburyo Salmon PDRN yihutisha kuvugurura uruhu, igabanya umutuku, kandi ishyigikira inzitizi zangiritse. Birakwiriye kuruhu rwibasiwe na acne hamwe nuburyo bwo gusana. Gushyigikirwa nubuvuzi kuri adenosine A₂A reseptor ya enterineti na synthesis ya kolagen.

Iriburiro: Impamvu Salmon PDRN Nibisanzwe Byizahabu Byiza byo Gusana Uruhu

Ahantu nyaburanga huzuye ibintu byoroheje - centella, panthenol, ectoin - abahatana bashya barimo kwiyongera cyane mubashinzwe kubitegura ndetse naba dermatologiste. Salmon PDRN (polydeoxyribonucleotide) ntagifungirwa gusa murwego rwohejuru rwo gutera inshinge muri koreya nziza; ubu ni a gushakishwa cyane nyuma yingirakamaro yibikorwa byingenzi bigamije uruhu rworoshye, rwangiritse, na nyuma yuburyo bukurikira .

Bitandukanye nuburyo gakondo bwo gutuza butuza gusa kurakara hejuru, PDRN kuruhu rworoshye ikora kurwego rwa selire. Ikora i adenosine A₂A yakira, gutangiza caskade yibimenyetso byo gusana bikangura Ikwirakwizwa rya fibroblast, angiogenezi ya VEGF-yunganirwa, hamwe na matrix idasanzwe . Kubirango byerekana amavuta yo gusana amavuta, serumu nyuma ya laser, cyangwa acne ikunda guhumuriza geles, Salmon PDRN itanga a uburyo bushya ibyo birwanya anti-inflammatories ntibishobora kwigana.

Iyi ngingo itanga abategura nabategura ibicuruzwa hamwe nincamake yuzuye ya Uburyo bwa Salmon PDRN, ibimenyetso byubuvuzi byo gutukura no gusana inzitizi, efficacy igereranya nibikorwa bisanzwe, hamwe nibitekerezo bifatika..

1. Mechanism: Uburyo Salmon PDRN isana uruhu rwangiritse kandi igabanya umutuku

1.1 Igikorwa cya Adenosine A₂A Kwakira: "Gusana Hindura"

Salmon ikomoka kuri PDRN hejuru ya 98% imiterere isa na ADN yabantu, gushoboza ingirangingo zuruhu kumenya no kuyisubiza neza. Bimaze gukoreshwa, PDRN isenywa na ectonuclease (CD39, CD73) muri adenosine, ihuza na A₂ reseptor kuri fibroblast na keratinocytes. Uku kubahiriza:

• Igenzura VEGF (imikurire y'amaraso ya endoteliyale) : Itezimbere capillary, itezimbere intungamubiri kumubiri wangiritse.

• Bitera EGF, FGF, na IGF: Kwihutisha re-epithelialisation no kubika kolagen.

• Kurwanya inzira NF-κB: Kugabanya cytokine itera inflammatory, igamije Kugabanya umutuku wa PDRN .

1.2 Inzira y'Agakiza: Gutanga inyubako zo gusana ADN

Itandukaniro ridasanzwe rya PDRN niyayo ibikorwa bibiri. Kurenga ibimenyetso, biratanga nucleotide ibanziriza unyuze munzira ya salvage-ingenzi mugihe selile ziri munsi ya hypoxic cyangwa inflammatory kandi ntishobora guhuza ADN de novo. Ubu buryo:

• Itanga purine na pyrimidine mu buryo butaziguye kuri fibroblast.

• Kwihuta gufunga ibikomere na re-epithelialisation muri bariyeri zangiritse.

• Gushyigikira anti-apoptotic ingaruka, kurinda selile kwangirika kwa UV- cyangwa gutwikwa.

Uburyo bwo gufata ibyemezo: Ibi ntabwo ari ibintu byoroheje gusa. PDRN ni a biopolymer itanga ibimenyetso byombi hamwe na substrate yo gusana imyenda.

2. Ibimenyetso bya Clinical: PDRN yo gutukura, gusana inzitizi, hamwe nuruhu rwa Acne

2.1 Ibikomere bidakira n'inzitizi zangiritse: Urufatiro rukomeye rwibimenyetso

Mugihe ibitekerezo byinshi byibanda kuburanga, amakuru akomeye yubuvuzi kuri PDRN akomoka gukiza ibikomere no gusana ingirangingo. Ikimenyetso cyihariye RCT ku bisebe bya diyabete (icyiciro cya Wagner 1-2) cyerekanye ko Abarwayi bavuwe na PDRN bageze kuri 37.3% barangije gufunga ibikomere na 18.9% mugucunga (p = 0.003) —Ubuvuzi bufite ireme bwo gutabara "bigoye-gukira".

Kubashinzwe intego gukira nyuma yuburyo bukurikira cyangwa kwangirika gukabije, ibi bimenyetso birasobanurwa neza. PDRN yerekanwe kuri:

• Kwihutisha kongera epithelialisation muri gutandukana-kubyimbye byuruhu rwabaterankunga .

• Kunoza gukira muri ibisebe by'amaguru iyo uhujwe na aside ya hyaluronike (67% gufunga na 22% hamwe na HA wenyine).

• Kongera corneal epithelial kuvugurura nyuma ya laser-bijyanye na periocular .

2.2 Dermatologiya yuburanga: Umutuku, Rosacea, nuruhu rwumva

Mubikorwa byiza, PDRN yo kuvura uruhu rwa rosacea na PDRN ituza serumu yibigize zirimo kugaragara nkibice bikura cyane. Gutandukanya-isura RCTs hamwe na cohort yo kwitegereza buri gihe raporo:

• Kunoza uruhu rworoshye hamwe na hydration ugereranije na aside hyaluronic.

• Kugabanya erythma yo mumaso—Muri Koreya yepfo, inshinge za PN / PDRN zimaze kuvurwa bisanzwe kugirango umutuku, nubwo ubusobanuro bwibanze burihuta.

• Umwirondoro wumutekano mwiza: Ibintu bibi biroroshye kandi byigihe gito (erythema, edema); nta mpungenge z'umutekano uhoraho.

Icyitonderwa cyingenzi kubashinzwe gutegura: Ikinyuranyo cyibimenyetso ntabwo kiri mubikorwa-kirimo ubuziranenge. Ibicuruzwa biratandukanye cyane muburemere bwa molekile, kwibanda, ninkomoko. Aha niho ubuhanga bwo gutegura ihinduka inyungu zo guhatanira.

3. Kugereranya Ingaruka: PDRN va Ibikoresho gakondo byo guhumuriza

Ubushishozi bw'ingenzi: PDRN ni ntabwo ari umusimbura kubisanzwe bisanzwe - ni a urwego rwohejuru rwo kuvugurura ibintu kubikorwa byo gusana byateye imbere. Kubitonda, kubungabunga buri munsi, centella cyangwa panthenol birahagije. Kuri inzitizi nyayo yo kwiyubaka no kugabanya umutuku kuruhu rworoshye, rukora, PDRN itanga uburyo ntakindi kintu cyibimera cyangwa vitamine gikomoka kuri vitamine gishobora gusaba.

4. Ibitekerezo byo gutegura: PDRN mubikorwa byingenzi

4.1 Guhagarara no guhuza

PDRN ni amazi ashonga, afite uburemere-buke bwa polinucleotide. Abashinzwe gutegura bagomba gutekereza:

• pH ituze: Urwego rwiza 5.0–7.0; irinde aside ikabije cyangwa alkaline.

• Ubushyuhe: Irinde ubushyuhe burebure (> 60 ° C) mugihe cyo gukora.

• Guhuza: Gukomatanya hamwe acide hyaluronic, niacinamide, na ceramide; irinde imbaraga zikomeye za okiside.

4.2 Basabwe gukoresha Urwego nu mwanya wibicuruzwa

* Icyitonderwa: Muri vitro data yerekana 0.01% PDRN itera fibroblast ikwirakwizwa na 25 ng / mL EGF; 0.08% byongera cyane synthesis ya kolagen. *

4.3 Ibimera-bishingiye ku bimera hamwe nubundi buryo: Guhindura irambye

Kubirango bishakisha ibikomoka ku bimera PDRN ku ruhu rworoshye cyangwa isuku yerekana ikirango, ibimera bikomoka kuri PDRN (uhereye kuri algae yijimye cyangwa Platycladus orientalis) na synthique recombinant PDRN ubu birahari mubucuruzi. Ubundi buryo butanga:

• Ugereranije A₂ Gukora reseptor na fibroblast.

• Ubushobozi buke bwo gukingira indwara (nta bisigazwa bya poroteyine bikomoka ku mafi).

• Umutekano urenze muri sisitemu zimwe na zimwe.

Abashinzwe gutegura: Kugaragaza niba isoko yawe ari salmon ikomoka, ibimera, cyangwa sintetike muri INCI yawe na dosiye ya tekiniki. Buriwese ufite solubilité zitandukanye, viscosity, hamwe numwirondoro.

5. Kwemeza Isoko: Intsinzi ya PDRN Yuruhu Rworoshye

Kuyobora K-ubwiza nibirango byisi bimaze gucuruzwa PDRN kuruhu rworoshye hamwe no gukurura abaguzi:

• SUNGBOON EDITOR Alaska Salmon PDRN Ultra Moisturizing Barrière Cream: Yakozwe na PDRN, niacinamide, aside hyaluronic, na ceramide. Muburyo bwa Clinical for kumurika ibibara byijimye, inkovu zikiza, no koroshya uruhu rworoshye / amavuta .

• Medicube Salmon ADN PDRN Umutuku wa Collagen Capsule Cream: Sisitemu ya capsule-gel sisitemu. Bipimishije amata yoroheje abereye uruhu rworoshye, gutanga hydrata ako kanya hamwe no kuzamura 33% byoroshye mugihe cyibyumweru bibiri.

• Dr.REJU-BYOSE BIKURIKIRA PDRN: 1200PPM yibanze, ihagaze kuri umutuku, gukama, guhinda, no kwita kubuvuzi bwa nyuma yubuvuzi .

Ubushishozi bw'umuguzi: Hejuru idakenewe mubisobanuro bya PDRN ntabwo ari efficacy-ni imyenda hamwe no kwisiga byihuse. Isubiramo ribi ritanga urugero “Biremereye, bifatanye, buhoro buhoro.” Ibirango bikemura uburambe mugihe kugumana imikorere mishya bizafata igice "kidakwiriye ikirahure cya buri munsi".

6. Umwirondoro wumutekano numutekano kubashinzwe

6.1 Incamake yumutekano

Mu myaka ibarirwa muri za mirongo ikoreshwa mu mavuriro (Ubutaliyani bwemeje PDRN yo gusana ingirangingo muri 2008), PDRN irerekana:

• Nta bintu bikomeye bifitanye isano nibiyobyabwenge muri RCT nini.

• Ubudahangarwa buke kubera kwezwa gukabije (> 95% bya ADN, proteyine / peptide idakora).

• Icyitonderwa: Amafi-allergique yabaturage agomba kwirinda PDRN ikomoka kuri salmon; ibimera-bishingiye cyangwa ibihimbano bisabwa.

6.2 Imiterere yisi yose

Inshingano yabashinzwe: Niba ugamije ibyoherezwa mu mahanga, kugenzura inshinge hamwe no kwisiga gutondekanya ku isoko rigamije. Amavuta yo kwisiga yibanze ahura nimbogamizi nkeya ugereranije nibicuruzwa byibiyobyabwenge.

Umwanzuro: PDRN Nibintu bishya byubaka ibyiyumvo byuruhu Byategereje

Salmon PDRN kuruhu rworoshye kandi rwangiritse ntabwo ari ibicuruzwa byo kwamamaza - ni a ubukanishi butandukanye, byemewe mubuvuzi ingirakamaro ikora icyuho hagati kwitaho buri munsi na kuvugurura ibice byukuri.

Kuri uwashizeho, itanga:

• A. uburyo bubiri (signal + substrate) itaboneka muri botanika cyangwa vitamine.

• Kwizerwa kwa Clinical kuva gukira ibikomere nubuvuzi bwiza.

• Amasoko yoroheje .

Kuri ikirango, itanga:

• A. umwanya wo hejuru inkuru ishingiye kuri siyanse, ntabwo ari impuha.

• Itandukaniro ryerekana munzira nyabagendwa "uruhu rworoshye".

• Kugaragaza neza abaguzi mukugabanya umutuku, gusana inzitizi, no gutunganya imyenda.

Igisekuru kizaza cyibisubizo byuruhu ntabwo bizoroha gusa. Bazavuka bundi bushya. Salmon PDRN nurufunguzo.