Gukoresha Inganda za Superoxide Dismutase (SOD): Ibiryo, Pharma & Cosmetics 

Intangiriro

Superoxide dismutase (SOD) ni enzyme ikomeye ya antioxydeant ihindura radicals ya superoxide muri ogisijeni na hydrogen peroxide, ikoreshwa cyane mubiribwa, farumasi, no kwisiga.

Uburyo bwibikorwa (Ibisobanuro birambuye)

Igisubizo Catalysed: SOD itera reaction: 2O₂⁻ + 2H⁺ → H₂O₂ + O₂. Mu yandi magambo, ihindura radicals ebyiri za superoxide muri molekile imwe ya hydrogen peroxide na ogisijeni, bigabanya cyane imbaraga za okiside.

Cofactors na Isoforms: Imisemburo ya SOD isaba ibyuma bya ion kurubuga rwabo rukora. Ubwoko busanzwe burimo Cu / Zn-SOD (cytosolike, ikoresha umuringa na zinc), Mn-SOD (mitochondrial, manganese), na Fe-SOD (muri bagiteri zimwe). Urubuga ruhuza ibyuma (akenshi bihuzwa na histidine hamwe nibisigara bya aspartate) byorohereza ihererekanyabubasha muri cycle yo gutandukana.

Uruhare rw'ibinyabuzima: Mugutandukanya radicals ya superoxide, SOD irinda ADN, lipide, na proteyine kwangirika kwa okiside. Uru ruhare ni ingenzi muri sisitemu yo kwirwanaho kandi rushyigikira imikoreshereze ya SOD mugukemura ibibazo bijyanye na okiside-stress.

Gusaba mu nganda zibiribwa

Kubungabunga ibiryo: Igikorwa cya antioxydeant ya SOD irinda lipide nintungamubiri mu biribwa. Ihanagura radicals ya superoxide yakozwe mugihe cyo kubika no kuyitunganya (ubundi byangiza vitamine, amavuta, nibindi). Rero SOD irashobora gukora nka a kubungabunga ibidukikije kwagura ubuzima bwamavuta menshi cyangwa ibiryo bishya.

Ibiribwa n'ibinyobwa bikora: SOD yongewe kubiribwa byubuzima ninyongera. Abashakashatsi bakoze ibicuruzwa bikungahaye kuri SOD (urugero: “SOD kuramba vino,” mayoneze ikungahaye kuri SOD, bombo y'amata, ibinyobwa) kugirango batange inyungu za antioxydeant binyuze mumirire. Inyongera ya SOD yo mu kanwa (capsules cyangwa ifu) igurishwa kugirango ibungabunge ubuzima kubera ingaruka zirwanya gusaza.

Imirire y’inyamaswa: Mu bworozi bw'amatungo n'inkoko, imisemburo ya SOD cyangwa kwigana ikoreshwa mu kuzamura ubuzima bw'inyamaswa ndetse n'ubwiza bw'inyama. Ubushakashatsi bwerekana ko wongeyeho SOD kugirango ugaburire byongera antioxydeant yinyamaswa (kuzamura ibikorwa bya serumu SOD, kugabanya ibimenyetso bya okiside). Ibi birashobora gusobanura gukura neza nubudahangarwa bwinyamaswa zirimwa.

Guhindura amata: Probiotics zimwe zitanga urwego rwo hejuru rwa SOD. Kurugero, umurongo wa Lactobacillus plantarum ikoreshwa muri yogurt yongereye cyane SOD yibicuruzwa byanyuma. Gutunganyiriza ibiryo bisembuye hamwe numuco utanga SOD birashobora kongera imirire yabo na antioxydeant.

Icyitonderwa: Ibihugu bimwe bifite amategeko agenga SOD mu biribwa. Urugero, Ubushinwa bwashyizeho ibipimo ngenderwaho kuri SOD irimo “ibiryo byubuzima” kandi ishishikariza iterambere ryabo, izi uruhare rwa SOD nka antioxydeant yimirire.

Porogaramu muri Pharmaceuticals & Healthcare

Umuti urwanya inflammatory: SOD ishakishwa nka antioxydeant ivura. Ibicuruzwa bya SOD Orgotein yakoreshejwe (yemejwe na FDA) mu kuvura umuriro n’imvune ziterwa n’imirasire ku bantu no ku nyamaswa. Muri ubwo buryo, SOD ikungahaye kuri SOD (urugero, kugirango ikoreshwe cyangwa iterwa inshinge) irimo gukorwaho iperereza kugirango igabanye kwangiza okiside mu ngingo.

Uburyo bw'indwara n'ibigeragezo: Ubushakashatsi bwerekana ko SOD ishobora kurinda ibihe bitandukanye. Kurugero, inshinge ya SOD yipimishije yarinze colitis mumbeba muguhagarika inzira yumuriro. Kurenza urugero SOD idasanzwe (SOD3) mubyitegererezo byinyamanswa bigabanya ubukana bwa artrite no kwangirika kwa stroke. Ubu bushakashatsi bwerekana ko imiti ishobora gukoreshwa mu gutwika, indwara z'umutima, n'iz'imitsi.

Antioxidant Inyongera: Inyongera ya SOD yo mu kanwa (nutraceuticals) irazwi kubuzima rusange. Urugero rumwe ni Glisodin - amata ahuza SOD ikomoka kuri melon na gliadin ingano kugirango irinde enzyme munda. Glisodine (ifu yumye ya SOD yumye) ikomeza gukora mububiko kandi byagaragaye ko izamura antioxydeant mumaraso yabantu.

Iterambere rya Biotech & Ibiyobyabwenge: Iterambere ririmo recombinant muntu SOD na SOD bigana. Ibigo nka Novartis (Chiron) byahaye imisemburo ya recombinant SOD enzymes zo gukoresha ibiyobyabwenge. Ibibazo byo gutanga (SOD ni poroteyine yakiriwe neza) bikemurwa nubuhanga nka PEGylation cyangwa encapsulation.

Imiterere y'isoko: Mu rwego rwa farumasi, SOD iraboneka nka enzymes zatewe inshinge (kubushakashatsi / gukoresha ivuriro), inyongera zo mu kanwa, hamwe nibisobanuro byingenzi. Ibisabwa muri farumasi nubuvuzi nigice cyambere cyo gusaba, kigaragaza uruhare rwacyo mubuvuzi bwo kwirinda no kuvura niche.

Porogaramu mu kwisiga & Kwitaho wenyine

Kurwanya gusaza uruhu: SOD ni antioxydeant "inyenyeri" mu kwisiga. Ihindura radicals yubusa ituruka kuri UV n’umwanda, bikaba intandaro yambere yo gusaza kwuruhu. Mugukata ROS, SOD irinda gusenyuka kwa kolagen na elastine, ifasha uruhu kuguma rukomeye kandi neza. Ubuvanganzo bwo kwisiga bwerekana ko SOD yibanze ishobora gutuma uruhu “rworoshe kandi rworoshye” kandi rugateza imbere ubuzima bwiza bwa kolagen.

Kurinda izuba no kurwanya umuriro: Ubushakashatsi bwerekana ko gukoresha SOD (akenshi bifitanye isano na peptide yinjira mu ruhu) byongera cyane UV kurwanya uruhu rwabantu. Kurugero, formulaire ya TAT-SOD yongereye urugero rwa erythma (izuba ryaka) byibuze ~ 37% kandi igabanya kwangirika kwingirabuzimafatizo ya UVB ~ 48%. SOD ifite kandi ingaruka zo kurwanya inflammatory: ifite umutekano (idafite uburozi) kandi irashobora kugabanya umutuku no kurakara.

Ibicuruzwa byubucuruzi: Ibirango byinshi byita kuruhu ubu birimo SOD mumavuta, serumu, izuba ryizuba hamwe n umusatsi / imisumari. Ingero zizwi cyane (zishingiye kuri raporo zinganda) zirimo Estée Lauder, Guhitamo kwa Paula, Revitol, hamwe nibiranga ubwiza bwa Aziya bitandukanye. Imiterere yubuvanganzo nkibimera SOD (urugero: melon SOD “Extramel”) nayo ikoreshwa nkibikoresho byo kurwanya stress.

Inzira: Inganda zo kwisiga zirimo guhanga udushya na SOD mu kuyihuza nibindi bikorwa (vitamine, peptide) muburyo bwo kurwanya gusaza. Hariho kwiyongera kwa "antioxydants" isukuye kandi ikomoka kuri kamere, bityo SODs ikomoka ku bimera na fermentation ikomoka cyane.

Sourcing SOD: Ifu, Recombinant, nabatanga isoko

Inkomoko: Inganda SOD yigeze gukurwa mubice byinyamanswa cyangwa ibimera, ariko umusaruro wari muke. Muri iki gihe, SOD nyinshi ikorwa hifashishijwe fermentation ya mikorobe cyangwa ibinyabuzima bya recombinant. Indwara ya bagiteri, umusemburo cyangwa algae birashobora guhingurwa kugirango bibyare umusaruro SOD, bigatuma ifu ya enzyme nini cyane.

Recombinant SOD: Abatanga ibicuruzwa benshi batanga recombinant muntu cyangwa ibimera SOD, itanga ubuziranenge buhoraho. Kurugero, Cu / Zn-SOD yabantu yagaragaye muri E. coli n'umusemburo ku musaruro mwinshi. Umusaruro wa recombinant nawo wemerera injeniyeri (urugero: thermostable cyangwa PEGylated variants) kugirango yongere imikorere.

Imiterere y'ibicuruzwa: SOD isanzwe itangwa nkifu ya lyofilize (gukonjesha-yumye) hamwe nibikorwa byihariye kuri mg. Irashobora kandi guhindurwa muri capsules, ibinini, cyangwa granules kugirango byongerwe, hanyuma bikabanza kuvangwa mumavuta cyangwa ibiribwa. Amakuru ahamye (ubuzima bwubuzima, kwihanganira ubushyuhe) ni ngombwa; ifu ya SOD yemewe ikomeza gukora kumyaka yubushyuhe bwicyumba.

Abaguzi Bakuru: Ibigo byinshi byikoranabuhanga bigurisha ifu ya SOD na enzymes. Harimo abatanga rusange reagent (Sigma-Aldrich, Roche, Enzo Ubuzima bwa Enzo, nibindi) hamwe nababikora kabuhariwe (urugero: Amano Enzyme mubuyapani, Luminex, Enzymes zihanga). Iyo ushakisha a “Utanga ifu ya SOD”, abaguzi binganda bakunze gushakisha ubuziranenge-bwiza, buranga SOD (inkomoko ya recombinant irasanzwe).

Recombinant vs Kamere: Amaturo yo ku isoko arimo SOD "karemano" (urugero: ibishishwa bya melon, umusemburo wa patenti SODs) hamwe na recombinant. Recombinant SOD isanzwe itoneshwa muri pharma / ibiryo kugirango bisukure kandi bihamye. Ku kwisiga, ibimera bya SOD biva mu bimera bishobora kugurishwa kubirango bisanzwe, ariko amasoko yose akora chimie imwe yo gutandukana.

Imigendekere yisoko & Icyerekezo cyakarere

Kwiyongera gukenewe: Muri rusange, ibisabwa kuri SOD biterwa nubuzima bwiza hamwe na demokarasi ishaje. Isoko ririmo imiti (imiti), intungamubiri (inyongera / ibiryo), no kwita kubantu. Abasesenguzi bavuga ko kwagura ikoreshwa rya SOD mu mirire ya siporo, ibiryo bikora, no kwita ku ruhu.

Iterambere ryiza: Inzira ni uburyo bwo gutanga udushya kuri SOD - liposomal na nano-igizwe na SOD irimo gutezwa imbere kugirango irusheho kwinjizwa no gutuza mumubiri. Izi tekinoroji zigamije gutsinda ihungabana rya SOD no gukora ibicuruzwa byiza byo munwa cyangwa byingenzi.

Ibikurubikuru by'akarere:

Amerika y'Amajyaruguru: Ikomeye muri pharma / therapeutics hamwe ninyongera zimirire (R&D nyinshi, amafaranga y'abaguzi).

Uburayi: Hashyizweho isoko hibandwa kubicuruzwa byubuzima karemano hamwe namategeko yo kwisiga / farumasi.

Aziya-Pasifika: Iterambere ryihuse (Ubushinwa, Ubuyapani, Koreya, Ubuhinde). Gutera imbere kuruhu no kurwanya gusaza hiyongereyeho gukoresha imirire gakondo ikenerwa na peteroli. Kurugero, Ubushinwa bufite ubuziranenge bwibiribwa byubuzima birimo SOD.

Ahasigaye kwisi: Amerika y'Epfo n'Uburasirazuba bwo hagati / N. Afurika yerekana iterambere rito mubicuruzwa byiza nishoramari ryibinyabuzima.

Umwanzuro / Urucacagu

Ingingo z'ingenzi: SOD ninganda zinyuranye zinganda bitewe nuburyo bukoreshwa na antioxydeant ya enzyme. Mu biribwa, ibungabunga ubuziranenge kandi ikungahaza ibikomoka ku buzima; muri farumasi irashakishwa kuvura ibyangiritse kandi yemeye gukoresha imiti ivura niche; kwisiga irinda kandi ikavugurura uruhu.

Ishirahamwe: Ingingo itunganijwe neza yatangiza ubumenyi bwa SOD (uburyo, ubwoko), hanyuma igacengera muri buri gice cyinganda (Ibiribwa, Farma, Amavuta yo kwisiga) hamwe nibisobanuro bya tekiniki (inzira zifatika, ingero, ibicuruzwa) hamwe nisoko. Hanyuma, shyiramo igice kijyanye no gushakisha SOD (ifu na recombinant) kugirango ukemure ijambo ryibanze kuri "Abatanga ifu ya SOD." Buri gice kigomba kwerekana ubushakashatsi cyangwa amakuru yinganda kugirango byuzuze ibisabwa bya tekinike.

Icyitonderwa cya nyuma: Kugaragaza ingero zibicuruzwa (urugero: ibiryo bikungahaye kuri SOD, Orgotein, SOD mubuvuzi bwuruhu) hamwe namakuru yubumenyi (ibikorwa bya enzyme, imikorere) bizashimisha abasomyi ba tekinike nababigize umwuga. Ingingo igomba guhuza amakuru yubumenyi (cofactors, reaction kinetics) hamwe namakuru afatika (porogaramu, imigendekere yisoko, abatanga isoko) kugirango bashishikarize abumva.