Chii chaizvo chinonzi PDRN? Nei ichirumbidzwa se“kiyi pakurapa kwomuviri patsva”? 

Muminda ye skincare uye aesthetic mushonga, "kuzvarwa patsva" ipfungwa inokwezva. Kana ganda rikakuvadzwa kana kuchembera, tinogara tichitarisira kumutsa kugona kwayo kugadzirisa. PDRN ndiyo chaiyo "kiyi" iyo nzanga yesainzi ichangobva kuwanikwa kuti inyatso kumisa maitiro ekugadzirisa masero. Nhasi, tichazivisa zvakavanzika zvayo.

Mabviro: Kufemerwa kubva kusimba rekuvandudza renyanza

PDRN (Polydeoxyribonucleotide), ine zita rakazara polydeoxyribonucleotide, haisi chigadzirwa chemakemikari, asi kuti chinobva mumasero ekubereka esalmon.

Masayendisiti akawana kuti salmon ine simba rekuvandudza tishu uye kugona kugadzirisa. Kuburikidza nekumwe tsvagiridzo, vakaburitsa iyi chaiyo DNA chidimbu-PDRN-kubva kusalmon urume. Iyi DNA yakafanana zvakanyanya muchimiro chepakati kune DNA yezvose zvinoyamwisa (kusanganisira vanhu), ichiratidza yakanakisa biocompatibility uye njodzi yakaderera yekurambwa kwekudzivirira, nekudaro ichibvumira kushandiswa kwayo kwakachengeteka uye kunoshanda mumuviri wemunhu.

Essence: Haisi "chigadzirwa" chete, asiwo "chiratidzo."

Tinogona kunzwisisa maitiro ekuita kwePDN kubva pamativi maviri epakati:

Se "kugadzirisa zvinhu": PDRN inoumbwa neakawanda deoxyribonucleotides (iyo yakakosha zvikamu zveDNA). Kana matishu eganda akuvadzwa uye maseru anoda kupatsanurwa uye kuwanda kuti apedze kugadzirisa, idzi nucleotide dziri nyore dzinogona kushandiswa zvakananga nemaseru semidziyo yekugadzira DNA nyowani, nekudaro kukurumidza kugadzirisa.

Se "chiratidzo chekugadzirisa": Iyi ndiyo inonyanya kukosha uye yakasarudzika maitiro ePDRN. PDRN inogona kunyatsozivikanwa nemasero akakomberedza akakuvadzwa kana hypoxic tishu uye anosunga kune adenosine A2A receptors pane cell surface, inhibiting iyo NF-kB uye MAPK nzira dzekuratidzira dzakaitwa neROS.  Izvi zvinoderedza kugadzirwa kwepro-inflammatory cytokines (IL-6, IL-1β, TNF-α, nezvimwewo) uye inosimudzira kutaura kwe-anti-inflammatory cytokines (IL-10), nokudaro ichiita simba rinopesana nekuputika.  Uyezve, inokurudzira kugadzirwa kweEGF (epidermal growth factor), FGF (fibroblast growth factor), VEGF (vascular endothelial growth factor), uye angiopoietin, ichipa PDRN yakanakisa anti-kuzvimba uye kuporesa maronda.

Core basa: Cheni yekugadzirisa kubva kune micro kusvika kune macro level.

Zvichienderana nemaitiro anotsanangurwa pamusoro, PDRN inoshandisa nhevedzano yeakabatana maitiro akanaka padanho reganda:

Inosimudzira angiogenesis: Inowedzera kugoverwa kweropa kunzvimbo yakakuvadzwa, kuunza okisijeni yakawanda uye kudya uye kubvisa tsvina yemetabolism.

Inokurudzira kuwedzera kwesero uye kutama: Inowedzera chiitiko uye nhamba yemasero makuru ekugadzirisa akadai se fibroblasts uye keratinocytes.

Inomutsa collagen uye elastin synthesis: Inosimbisa chimiro cheganda kubva kune dermis, inovandudza mitsetse yakanaka uye inowedzera elasticity.

Simba rekurwisa-kuzvimba mhedzisiro: Zvinonyatso kunyaradza maitiro ekuzvimba sekutsvuka, kuzvimba, kupisa, uye kurwadziwa nekugadzirisa zvinokonzeresa zvinhu.

Kugadzirisa matishu uye kuporeswa kwemaronda:  Kubatanidza zvese zviri pamusoro apa, zvinokurumidzisa kupora kwekukuvara kwakasiyana siyana kweganda.

PDRN inonzi "kiyi yekuzvarwa patsva" nekuti haingogadziri uye inopa chikafu, asi inonyatso gadzirisa sero basa.  Zvichienderana neiyo yakakwirira biocompatibility, inomisikidza iyo ganda rega regene regene kuburikidza neakawanda-nzira nzira synergistic mhedzisiro. Iyi nzira ye "kumutsa intrinsic kugadzirisa masimba" ndiyo inonyanya kutsvaga mumunda wekuzvarwa patsva, uye ndiyo inopa PDRN chinzvimbo chayo chisingachinjike mumunda wehutano hweganda.