
2026-09-29
45S5 i-Bioactive Glass Powder ukubunjwa okucacileyo kweglasi ye-silicate (45% SiO2, 24.5% Na2O, 24.5% CaO, kunye ne-6% ye-P2O5 ngesisindo) eyenzelwe ukudibanisa nethambo eliphilayo kunye nezicubu ezithambileyo. Njengomboneleli okhethekileyo wezinto ezisebenza kakhulu ekrwada, IJinan Meiyi Biotechnology Co., Ltd. ibonelela ngobunyulu obuphezulu, i-micronized 45S5 umgubo wofakelo lwe-biomedical, ii-composites zamazinyo, kunye neyeza lokuvuselela. Imodeli yethu yobuchule yokukhangela ixhasa iilebhu ze-R&D, abavelisi bezixhobo zonyango, kunye nemveliso yomgangatho wemizi-mveliso, iqinisekisa ukuhanjiswa kobungakanani bamasuntswana, i-stoichiometry yekhemikhali engqongqo, kunye nokuthotyelwa kwemigangatho ye-biocompatibility yehlabathi.
I-45S5 i-Bioglass® imele isizukulwana sokuqala sezinto eziphilayo ezikwaziyo ukwenza ibhondi eyomeleleyo kunye nethambo lomkhosi. Igama elithi "45S5" lichaza ukubunjwa kweekhemikhali: 45 wt% silica (SiO2) kunye ne-5: i-1 ye-molar ratio ye-calcium kwi-phosphorus. Ngokungafaniyo ne-inert biomaterials ezifana ne-titanium okanye i-alumina, exhomekeke kwi-mechanical fixation, i-45S5 ye-bioactive glass powder iqalisa uchungechunge oluguquguqukayo lokusabela komphezulu xa luvezwe kumanzi obomi.
Esi sixhobo sasungulwa nguNjingalwazi uLarry Henchey kwiYunivesithi yaseFlorida. Namhlanje, isengumgangatho wegolide kuphando lwe-bioactivity kunye nokusetyenziswa kweklinikhi. Ifom yomgubo ivumela ukudityaniswa okuguquguqukayo kwiipolymers, iisamente, kunye nezikafula, okwenza iinjineli kunye neekliniki zilungelelanise iimpawu zoomatshini kunye nebhayoloji yezixhobo zonyango zokugqibela.
Ukusebenza kwe-45S5 powder kuxhomekeke kubuchule bayo obukhethekileyo bokutshintshana ngokukhawuleza kwe-ion. Ekudibaneni nolwelo lomzimba, i-sodium kunye ne-calcium ions iphuma kumphezulu weglasi, inyusa i-pH yendawo kwaye ibangela ukuna kwemvula ye-carbonated hydroxyapatite (HCA) layer. Olu luhlu lwe-HCA lufana neekhemikhali kunye nesakhiwo esifana nesigaba samaminerali sethambo lendalo, ukuququzelela i-osteoconduction ngqo kunye ne-osteostimulation.
Kubavelisi kunye nabaphandi, ukuqonda le ndlela kubalulekile. Umlinganiselo wokusabela uxhomekeke kwizinto ezininzi, kuquka:
Ukuvelisa kunye nokukhangela umgangatho ophezulu we-45S5 umgubo weglasi we-bioactive kufuna ulawulo oluchanekileyo phezu kokukhethwa kwezinto ezikrwada, amaqondo obushushu okunyibilika, kunye neenkqubo zokugaya. Nge IJinan Meiyi Biotechnology Co., Ltd., ikomkhulu eJinan, kwiPhondo laseShandong, sisebenza njenge-subsidiary ye-Pacific Kangtai Scientific Instruments (Jinan) Co., Ltd., ezinikele kuphando, ukuxhasa uphuhliso, kunye nokuthengiswa kwe-bioactive technologies. Ngelixa singazibandakanyi kwimveliso ethe ngqo, sisebenza njengeqhinga lokukhangela kunye neqabane lokuhambisa eliqinisekisiweyo lomgangatho, sixhasa ubudlelwane bentsebenziswano bexesha elide kunye nabavelisi abavunyiweyo bamazwe ngamazwe, abaqinisekisiweyo.
Imodeli yethu yokusebenza ibeka phambili ukuthembeka kunye nokungafihli. Siqinisekisa ukuba yonke ibhetshi ye-45S5 powder ibambelela kwiiNdlela zokuSebenza eziLungileyo zoMveliso (GMP) kunye neenkqubo zokulawula umgangatho wamazwe ngamazwe. Le ndlela yokusebenzisana isenza sikwazi ukubonelela ngokuhambelana kwebhetshi-to-batch, okubalulekileyo ekuvunyweni okusemthethweni kwisixhobo sonyango kunye nezicelo zobuhle.
Inkqubo iqala ngezinto ezicocekileyo ezicocekileyo, ezibandakanya i-silicon dioxide, i-sodium carbonate, i-calcium carbonate, kunye ne-phosphorus pentoxide. Ukungcola okunje ngesinyithi esinzima kufuneka kuncitshiswe ukukhusela i-cytotoxicity. La macandelo axutywe ngokwemilinganiselo ngqo kwaye anyibilike kumaqondo obushushu angaphezu kwe-1300 ° C ngamaqabane ethu okuvelisa aqinisekisiweyo. Oku kunyibilika kobushushu obuphezulu kuqinisekisa ubume beglasi obulinganayo ngaphandle kwezigaba zekristale ezinokubeka esichengeni i-bioactivity.
IJinan Meiyi Biotechnology igcina indlela yokufundisa eqeqeshekileyo. Zonke imathiriyeli ekrwada zivavanywa ngokubanzi phambi kokuba zibandakanywe kwipotfoliyo yethu, kunye neendlela zokhetho ezisekelwe kwidatha esebenzayo, iiprofayili zozinzo, kunye nokuhambelana nemigangatho yoyilo lwangoku. Siqinisekisa ukubunjwa okusisiseko kwaye siqinisekisa ukuthotyelwa kwefomula ye-45S5 ngokuphononongwa ngokungqongqo kwamaxwebhu kunye nokuqinisekiswa kwemigangatho yebhetshi.
Emva kokucima kunye nokutyumza, i-glass frit i-milled ukuze ifezekise ukuhanjiswa kwesayizi ethile. Sinikezela ngeenkonzo ezilungelelanisiweyo zokusebenzisa inethiwekhi yethu yokubonelela ukuhlangabezana neemfuno ezahlukeneyo zezicelo:
Izinto zethu eziphambili kunye neenkqubo zolawulo lomgangatho ziqinisekisa ukuhanjiswa kobungakanani besuntswana elimxinwa, ukunciphisa i-agglomeration kunye nokuphucula ukuqukuqela kokusetyenzwa komsinga.
Yonke ibhetshi ye-45S5 yomgubo isasazwe nguJinan Meiyi Biotechnology ivavanywa ngokuqatha phambi kokukhululwa. Isakhelo sethu soqinisekiso lomgangatho sigxile kwisiqinisekiso somthengisi kunye nokulandelelwa kwamaxwebhu, kubandakanywa:
Imathiriyeli ekrwada nganye ikhatshwa ziidosi zobugcisa ezipheleleyo, kubandakanywa iZatifikethi zoHlalutyo (CoA), iiNkcukacha zoKhuseleko lweMpahla (MSDS), kunye nezishwankathelo zobume bolawulo apho kufanelekileyo.

Xa kufunwa i-45S5 i-bioactive glass powder yokusetyenziswa kwimizi-mveliso okanye kwezonyango, iiparitha ezichanekileyo zobugcisa zibalulekile ekusebenzeni kwemveliso. Le theyibhile ilandelayo ichaza imilinganiselo esemgangathweni yomgubo wethu webakala leprimiyamu. Imiba ethile iyafumaneka xa iceliwe kwiiprojekthi ezikhethekileyo zeR&D.
| Ipharamitha | Inkcazo esemgangathweni | Indlela yoVavanyo |
|---|---|---|
| Ukuqulunqwa kwemichiza | 45% SiO2, 24.5% Na2O, 24.5% CaO, 6% P2O5 (wt%) | I-ICP-OES |
| Ulwakhiwo | I-Amorphous (Non-crystalline) | XRD |
| Ubungakanani besuntswana (D50) | Ukwenziwa ngokwezifiso: 0.5 µm - 500 µm | I-Laser Diffraction |
| Ubunyulu | > 99.9% | Uhlalutyo lweGravimetric |
| Iintsimbi ezinzima | < 10 ppm (Itotali) | I-ICP-MS |
| IKlasi yeBioactivity | Udidi A (Bonding Index > 0.5) | Uvavanyo lokuntywiliselwa kwe-SBF |
| Umxholo wokufuma | < 0.5% | Uhlalutyo lwe-Thermogravimetric |
| Ukupakishwa | Izikhongozeli ezivaliweyo zitywiniwe, azikwazi ukufuma | UHlolo Olubonwayo |
Ukuguquguquka kwe-45S5 powder kwenza ukusetyenziswa kwayo kuluhlu olubanzi lwe-biomedical kunye namashishini ezempilo. Ukusuka kukufakelwa kwamathambo ukuya kwiimveliso zokhathalelo lwemihla ngemihla, amandla ezinto eziphathekayo okuvuselela ukuvuselelwa kwezicubu kuqhuba izinto ezintsha kumacandelo amaninzi. IJinan Meiyi Biotechnology inceda abathengi kulo lonke elase-Asiya, iYurophu, kunye noMntla Melika, ngamandla athile ekuxhaseni iilabhoratri ze-R&D, uphuhliso lwekhontrakthi kunye nemibutho yokuvelisa (CDMOs), kunye neekliniki zobuhle ezifuna izisombululo ezahlukileyo, ezixhaswa yisayensi.
Kwi-orthopedic operation, i-45S5 powder iyona nto ibalulekileyo kwi-bone graft substitutes. Ihlala ifakwe kwi-scaffolds ene-porous okanye ixutywe kunye neepolima ezifana ne-poly-L-lactic acid (PLLA) ukwenza izinto ezidibeneyo. Ezi ngqungquthela zidibanisa i-osteoconductivity yeglasi ye-bioactive kunye namandla omatshini weepolymers, ukubonelela ngenkxaso yesakhiwo ngelixa ukhuthaza ukukhula kwamathambo amatsha.
Izifundo zeklinikhi zibonise ukuba i-45S5-based implants implants idibanisa ngokukhawuleza kunye nethambo lomkhosi xa kuthelekiswa neengubo zendabuko ze-hydroxyapatite. Oku kunciphisa ixesha lokubuyisela kunye nokuphucula ukuzinza kwexesha elide lokufakelwa.
Ishishini lamazinyo ngomnye wabathengi abakhulu be-45S5 bioactive glass powder. Izicelo zayo ziquka:
Ukuqhubela phambili kwamva nje kwandise ukusetyenziswa kwe-45S5 powder ekunakekeleni amanxeba. Xa isetyenziswe kumanxeba angapheliyo, njengezilonda zesifo sikashukela, iincinci zeglasi zidibanisa ne-exudate yesilonda ukukhulula i-ion zonyango. Ezi ion zineempawu ze-angiogenic, zivuselela ukwakheka kwemithambo yegazi emitsha kunye nokukhawulezisa ukulungiswa kwezicubu. Ukongezelela, indawo ye-alkaline eyenziwe ngokutshintshiselana kwe-ion ibonisa imiphumo epholileyo ye-antibacterial, ukunciphisa umngcipheko wosulelo.
Abaphandi baqhubeka besebenzisa i-45S5 powder njengomphathi wokuhanjiswa kweziyobisi ezilawulwayo. Isakhiwo se-porous yeglasi ye-bioactive sinokulayishwa kunye ne-antibiotics, izinto zokukhula, okanye i-anti-inflammatory agents. Njengoko iglasi inyibilika kwindawo ye-physiological, ikhupha ezi arhente zonyango ngendlela eqhubekayo, ijolise kwiindawo ezithile ngelixa kwangaxeshanye ikhuthaza ukuvuselelwa kwezicubu.
Kwimarike enemigangatho eyahlukeneyo yobulunga, ukukhetha umthengisi ofanelekileyo kubalulekile kwimpumelelo yemveliso. Ifilosofi yethu yokuvelisa igxile ekuchanekeni, ukusulungeka, kunye nentsebenziswano. Nasi isizathu sokuba iinkampani ezikhokelayo zezixhobo zonyango kunye namaziko ophando akhetha yethu i-45S5 powder.
I-Bioactivity inovakalelo kakhulu kutshintsho lokuqamba. Ukuphambuka nokuba yi-1% kumxholo we-silica kunokutshintsha izinto ezivela kwi-bioactive ukuya kwi-bio-inert. Iinkqubo zethu zokudibanisa ezizenzekelayo kunye nohlalutyo lwexesha langempela luqinisekisa ukuba ikhilogram nganye ye powder ihambelana ngqo ne-45S5 stoichiometry efunekayo ukuze usebenze ngokufanelekileyo.
Siyaqonda ukuba isayizi enye ayilingani zonke. Ingaba ufuna i-nano-particles ye-hydrogels injectable okanye i-granules e-coarse ye-scaffolds eprintiweyo ye-3D, iteknoloji yethu yokugaya ivumela ulawulo oluchanekileyo malunga nokusabalalisa ubungakanani besuntswana. Sinokwenza i-D10, i-D50, kunye ne-D90 ixabiso lihambelane neemfuno zakho zokucwangcisa.
Kubenzi bezixhobo zonyango, ukuthotyelwa kwemigaqo kubaluleke kakhulu. Sinikezela ngeepakethe zamaxwebhu abanzi, kubandakanywa iZatifikethi zoHlalutyo (CoA), iMakhishithi yeDatha yoKhuseleko lweMathiriyeli (MSDS), kunye needosi zobugcisa ezineenkcukacha ezixhasa imigangatho yolawulo lwekhwalithi ye-ISO 13485. Oku kungafihlwa kukhawulezisa iinkqubo zakho zokungeniswa kwemithetho.
Ngokwandisa ikhonkco lethu lokubonelela kunye nokunyusa ukusebenza kakuhle kwemveliso, sinikezela ngamaxabiso akhuphisanayo ngaphandle kokubeka esichengeni umgangatho. Siyazixhasa zombini iiodolo ezincinci zeR&D kunye neekhontrakthi ezinkulu zemizi-mveliso, sibonelela ngamanqanaba amaxabiso aguqukayo akhula kunye neshishini lakho.

Ukuqonda indlela i-45S5 ethelekisa ngayo nezinye izinto eziphilayo kunceda ekwenzeni izigqibo zokukhetha ezinolwazi kwizicelo ezithile. Itheyibhile ilandelayo ibonisa umahluko ophambili phakathi kwe-45S5 yeglasi ye-bioactive, i-hydroxyapatite (HA), kunye neeramics ze-bioinert njenge-alumina.
| Uphawu | 45S5 Bioactive Glass | IHydroxyapatite (HA) | IAlumina (Inert) |
|---|---|---|---|
| UBonding Mechanism | Ibhondi yeMichiza nge-HCA umaleko | I-Osteoconductive (ukuhlanganiswa okucothayo) | Ukudityaniswa koomatshini kuphela |
| Izinga lokuphendula | Ukukhawuleza (iintsuku) | Kancinci (iinyanga) | Akukho nanye |
| I-Osteostimulation | Phezulu (ilungisa ukubonakaliswa kofuzo) | Phantsi | Akukho nanye |
| Amandla oomatshini | I-Brittle (ihlala isetyenziswa kwi-composites) | Brittle | Phezulu kakhulu |
| Iipropati ze-Antibacterial | Ewe (ngokuphakama kwe-pH) | Hayi | Hayi |
| Resorbability | Ukupheliswa okulawulwayo | I-resorption ecothayo kakhulu | Ayinakusetyenziswa |
Olu thelekiso lubonisa ukuba kutheni i-45S5 ihlala ikhethwa kwizicelo ezifuna ukuhlanganiswa ngokukhawuleza kunye nokusebenza kwebhayoloji, ngelixa ii-ceramics ezingasebenziyo zigcinelwe izihlanganisi ezinomthwalo ophezulu apho ukuzinza kuyinkxalabo ephambili.
Ukukhetha ukucaciswa okuchanekileyo kwe-45S5 powder kubandakanya ukulinganisa i-bioactivity, iimpawu zomatshini, kunye nemiqobo yokucubungula. Nasi isikhokelo sokukunceda ubone eyona nto ifanelekileyo kwiprojekthi yakho.
Kuba iimbumba zepolymer, iincinci ezincinci (1-5 µm) zinconywa ukuba kuqinisekiswe ukusabalalisa okufanayo kunye nokugcina ukunyaniseka komatshini we-polymer matrix. Amasuntswana amakhulu anokusebenza njengezigxina zoxinzelelo, ezikhokelela ekungaphumelelini kwangaphambi kwexesha.
Kuba izikafula kunye neesamente zamathambo, Ukusabalalisa okubanzi okanye iigranules ezinkulu (100-300 µm) kunokuba luncedo ukudala i-porosity, evumela ukuba i-vascular ingrowth kunye nokuthutha izondlo.
Ukuba isicelo sakho sibandakanya iitofu okanye ukudibana ngqo nezihlunu ezibuthathaka, khetha ibakala lethu lokucoceka okuphezulu kunye nemida engqongqo yentsimbi enzima. Kuba iimveliso zokunakekelwa kwamanxeba angaphandle okanye izixhobo ezingenakufakelwa, i-powder yodidi oluqhelekileyo lwezonyango lubonelela ngesisombululo esineendleko ngaphandle kokunciphisa ukhuseleko.
Qwalasela ukuba umgubo uya kwenziwa njani. Ukuba usebenzisa Ushicilelo lwe-3D iitekhnoloji ezifana ne-stereolithography (SLA), i-powder kufuneka ihambelane nenkqubo ye-resin kwaye ibe neempawu ezisezantsi zokusabalalisa ukukhanya. Kuba ukunyibilika-ukucima okanye i-sintering, ukuzinza kwe-thermal kunye ne-particle packing density zizinto eziphambili.
Ukugcinwa okufanelekileyo kubalulekile ukugcina umgangatho kunye ne-bioactivity ye-45S5 powder. Ngenxa ye-reactivity ephezulu, izinto eziphathekayo zi-hygroscopic kwaye ziyakwazi ukuhla xa zibonakaliswe kumswakama.
Ewe, iglasi ye-45S5 ye-bioactive inembali ebanzi yokusetyenziswa kwekliniki kwaye yamkelwa ngokubanzi njenge-biocompatible kwaye ikhuselekile. Isetyenziswe kumawaka eenkqubo zotyando kwihlabathi jikelele ukuvuselelwa kwamathambo kunye nokusetyenziswa kwamazinyo. Nangona kunjalo, njengakuyo nayiphi na imathiriyeli yezonyango, kufuneka iqwalaselwe kwaye ivalwe ngokwezikhokelo zolawulo ezifanelekileyo phambi kokufakwa.
Xa igcinwe kwi-original, engavulwanga, i-vacuum-sealed package phantsi kweemeko ezicetyiswayo, ubomi beshelufu ye-45S5 powder ngokuqhelekileyo ziinyanga ze-24. Nje ukuba ivulwe, kufuneka isetyenziswe kwiinyanga ezi-6 kwaye igcinwe kwi-desiccator ukuthintela ukufunxwa komswakama, onokuthi uqalise ngokukhawuleza ukusabela komhlaba.
Ewe, sinikezela ngeendlela zokupakisha eziguquguqukayo ukuze zihambelane nezinto zakho kunye neemfuno zemveliso. Ukupakishwa okusemgangathweni kubandakanya i-1kg, 5kg, kunye ne-25kg yeengxowa ezinobungqina bokufuma. Kubathengi abakwimizi-mveliso emikhulu, sinokubonelela ngobungakanani bemigqomo yesiko okanye izikhongozeli ezininzi ezinelayini ekhethekileyo yokuqinisekisa imfezeko yemveliso ngexesha lokuhamba.
Ewe, kuso nasiphi na isicelo sonyango esifakelwayo okanye esihlaselayo, ukuvala inzala kunyanzelekile. I-45S5 powder inokuthi ifakwe inzalo ngokusebenzisa i-gamma irradiation okanye i-ethylene oxide (EtO) igesi. I-autoclaving (i-steam sterilization) ayikhuthazwa ngokubanzi malunga nomgubo ocolekileyo njengoko kunokubangela i-agglomeration kunye ne-hydration yangaphambi kwexesha. Singaxoxa ngeeprothokholi zokuvala inzala ezilungiselelwe ukuhamba kwakho komsebenzi othile.
Amaxabiso ayahluka ngokusekelwe kubunzima benkqubo yokugaya. I-Nano-sized powders ifuna ukusetyenzwa okunamandla ngakumbi kunye nokulawulwa komgangatho ongqongqo, okukhokelela kwixabiso eliphezulu ngekhilogram nganye xa kuthelekiswa namabakala amancinci okanye ama-granular. Sinikezela ngezakhiwo zamaxabiso ehoseyili esobala esekwe kumthamo kunye nobunzima benkcazo.
Sixhasa abathengi kuwo onke amanqanaba ophuhliso. Ngeenjongo ze-R&D, sinikezela ngezixa ezincinci ukusuka kwi-100 grams. Kwimveliso yorhwebo, i-MOQ yethu ye-wholesale iqala kwi-25 kg, kunye nekhefu elibalulekileyo elikhoyo kwii-odolo ezidlula i-100 kg okanye i-1 toni.
Imarike yezinto ezisebenza ngebhayoloji ikhula ngokukhawuleza. Ngo-2026, sibona indlela ekhula ngayo biomatariyali esebenzayo. Abaphandi abasajongi nje ukudibanisa amathambo; bafuna izinto ezinokuhambisa amayeza, ukulwa nosulelo, kunye nokuvuselela i-angiogenesis ngaxeshanye. I-45S5 powder iphambili kolu lutsha.
Omnye umkhwa obalulekileyo kukudityaniswa kweglasi ye-bioactive kwi 3D bioprinting. Ukukwazi ukuprinta izikafula ezingqale kwisigulana kusetyenziswa i-bio-inks ye-bioactive glass-infused bio-inks kuguqula amayeza omntu. Amabanga ethu omgubo acudiswe kakuhle alungiselelwe ngokukodwa obu buchule bokwenza udidi oluphezulu, ukuqinisekisa ukukhutshwa okugudileyo kunye noshicilelo olunesisombululo esiphezulu.
Ngaphaya koko, uzinzo luba yingqwalasela ephambili. Iinkqubo zethu zokuvelisa ziyilelwe ukunciphisa inkcitho kunye nokusetyenziswa kwamandla, ukulungelelaniswa noxinzelelo lwehlabathi lokubonelela ngonyango oluluhlaza.
Ukukhetha umthombo ochanekileyo we 45S5 i-Bioactive Glass Powder sisigqibo esicwangcisiweyo esichaphazela umgangatho, ukusebenza kakuhle, kunye nempumelelo yolawulo lwemveliso yakho yokugqibela. Ngokuzibophelela kwethu ekuchanekeni kweekhemikhali, ubunjineli obunokwenziwa ngokwezifiso, kunye nokulawulwa komgangatho ongqongqo, IJinan Meiyi Biotechnology Co., Ltd. ibonelela ngesiseko esithembekileyo esifunwa yintsha yakho.
Ingaba uphuhlisa isizukulwana esilandelayo sokufakelwa kwamathambo, iimbumba zamazinyo eziphambili, okanye izisombululo zokunakekelwa kwamanxeba inoveli, i-45S5 yethu ye-powder ecocekileyo ihambisa i-bioactivity engaguqukiyo efunekayo kwimpumelelo yekliniki. Asingomthengisi nje; siliqabane lobugcisa elizinikele ekuxhaseni i-R&D yakho kunye neenjongo zemveliso ngokungqongqo kwezenzululwazi kunye nokusabela kwimarike.
Yiva umahluko weglasi yebhayoloji yenqanaba lokuqala. Qhagamshelana neqela lethu lokuthengisa lobuchwephesha namhlanje ukuze ucele isampuli, uxoxe ngeemfuno zakho zobungakanani besuntswana elithile, okanye ufumane isaphulelo esilungiselelweyo.
Thatha inyathelo elilandelayo kwi-biomaterial innovation:
→ Phonononga uluhlu lwethu olupheleleyo lweZisombululo zeglasi yeBioactive kunye neMithombo yobuGcisa