Imvumelwano yeNgcali kwiSicelo seKlinikhi ye-PDRN Acid kwiDermatology 

Kwiminyaka yakutshanje, i-polydeoxyribonucleic acid (PDRN) ifumene ingqwalasela ebanzi kunye nesicelo kwinkalo ye-dermatology, kodwa kusekho ukungabikho kokuqonda okudibeneyo malunga nokulinganisa kwesicelo sayo. Iqela le-Laser Cosmetology yeCandelo le-Chinese Medical Association ye-Aesthetic kunye nePlastiki kunye neQela le-Cosmetology yezoNyango ye-China Association of Integrative Medicine ngokudibeneyo ikhuphe "Imvumelwano yeNgcali kwi-Clinical Application ye-Polydeoxyribonucleic Acid kwi-Dermatology," ejonge ukubonelela oogqirha ngeengcebiso zesayensi kunye nenjongo yokubakhokela ekusebenziseni i-PD enengqondo.

I-Pharmacokinetics kunye ne-Mechanism of Action ye-PDN

I-PDRN ikhona kwi-plasma kwifomu yamahhala kwaye ayibopheleli kwi-plasma apolipoproteins. Ukuhanjiswa kwayo kuhambelana kakuhle nokuhamba kwegazi kwezicubu. Eli chiza alixutywanga sisibindi; ikakhulu ithotywa yi-plasma DNA nucleases okanye i-cell membrane nucleases ukwenza isithako esisebenzayo, i-mononucleotide. Ekugqibeleni, ininzi yayo ikhutshwe kumchamo (malunga ne-65%), kunye nexabiso elincinci elikhutshwe kwi-feces.

Ukutshatyalaliswa kwe-PDRN kuvelisa i-nucleotides kunye ne-nucleosides, ukubonelela ngezinto ezibonakalayo zokulungiswa komonakalo we-DNA kunye nokukhuthaza ngokukhawuleza ukulungiswa kwe-DNA yeseli eyonakalisiweyo kunye nokwanda kweeseli.

Ukusetyenziswa kweKlinikhi yePDRN kwiDermatology

1. Ukunyangwa Kwenxeba

Uphando lwangoku lufumene ukuba i-PDRN ithatha inxaxheba kwinkqubo yokuphulukisa isilonda ukusuka kwii-angles ezininzi, kubandakanywa nokuvimbela iimpendulo ezivuthayo ezigqithiseleyo, ukukhawuleza kwe-epidermal kunye nokuvuselelwa kwe-dermal, ukukhuthaza ukufakwa kwe-collagen, kunye nokunyusa i-angiogenesis kunye nezinye izinto ezilawulayo ezifana ne-VEGF. Kwizigulane ezifakwe kwi-autologous skin graft, i-intramuscular, subcutaneous, okanye i-topical PDRN iinaliti kwindawo yenxeba inokukhawulezisa i-epithelialization yenxeba kunye nexesha lokuphilisa. Ngaphezu koko, isicelo se-PDRN emva kwe-CO2 yonyango lwe-laser ye-fractional inokukhawuleza ukuphulukiswa kwesilonda; ngoko ke, i-PDRN inokuqwalaselwa emva konyango lwe-laser ablative ukukhuthaza ukuphulukiswa kwenxeba kunye nokubuyisela umsebenzi wokuthintela ulusu.

2. I-Melasma kunye ne-Post-inflammatory Hyperpigmentation:

Izizathu eziqhelekileyo ze-melasma kunye ne-post-inflammatory hyperpigmentation ikakhulu zibandakanya ukusebenza okungaqhelekanga kwee-melanocytes kunye neempendulo eziqhubekayo zokuvuvukala. I-PDRN inokulawula iindlela ze-kinase kunye ne-protein kinase B ngokuvula i-extracellular signaling kwi-melanocytes, ukunciphisa amanqanaba e-dysplastic angiotensin-related transcription factor, inhibite ukubonakaliswa kwe-tyrosinase kunye neeprotheni ezinxulumene ne-melanin synthesis, kunye nokunciphisa umxholo we-melanin we-melanocytes. Ngokonyango, i-PDRN inokuqwalaselwa kunye nezinye iindlela zokunyanga ukuphazamiseka kwe-pigmentary refractory njenge-melasma okanye i-post-inflammatory hyperpigmentation. 3. Ukuguga kolusu:

I-PDRN yenza i-adenosine i-A2A i-receptors okanye i-salvage pathways, iphakamisa i-cyclic adenosine monophosphate (cAMP) i-concentration, inqanda i-MMPs kunye ne-elastase secretion, ihlaziya i-matrix ye-extracellular, inciphisa imibimbi, ibuyisela ukuqina kwesikhumba, kwaye iphucula ukuthungwa kwesikhumba. Ngaphezu koko, uphando oluninzi lufumene ukuba i-PDRN inokunciphisa amanqanaba eenkalo ezahlukeneyo ze-pro-inflammatory ezifana ne-IL-6, IL-1β, TNF-α, kunye ne-IL-12, kunye nokulawula ukukhutshwa kwezinto ezivuthayo ezifana ne-IL-10. Oku kubonisa ukuba i-PDRN inokulibazisa ngaxeshanye ukwenzeka kunye nophuhliso lwe-photoaging yesikhumba ngokuthintela ukukhuselwa kwe-SASP, ukuphucula ukunyameka kwesikhumba, uburhabaxa, kunye neepores ezandisiweyo, kunye nokunciphisa ukulahleka kwamanzi e-transepidermal, ngaloo ndlela kujongana neengxaki zokuguga kwesikhumba.

4. Ukonakaliswa:

Kwimodeli yokupholisa igundane le-SD, iPDRN yafunyaniswa ukunciphisa ukungena kweseli evuthayo kwizicubu ezibomvu kunye nokuthintela ukwanda kwesiva esigqithisileyo ngokuthintela ukubonakaliswa kwe-HMGB-1. Izifundo zeklinikhi zamazwe ngamazwe ziye zafumanisa ukuba ukusetyenziswa kwangaphambili kwe-PDRN emva kwe-thyroidectomy kunokuphucula ngokubonakalayo ukuthungwa, umbala, kunye nobukhulu be-hypertrophic scars, ngokhuseleko olulungileyo kwaye akukho ziphumo zibi. Ngoko ke, ukungenelela kwangaphambili kunye ne-PDRN kunokuqwalaselwa ngamanxeba asemngciphekweni wokutshatyalaliswa. Okwangoku, akukho zifundo malunga nokusebenza kwe-PDRN kwi-keloids.

5. Androgenetic Alopecia:

Izigulane ezine-androgenetic alopecia zibonisa utshintsho lwe-scalp olufana nokunciphisa kunye nemithambo yegazi encinci. I-PDRN inokulawula indlela yokubonisa i-Wnt, ikhuthaze ukwanda kweenwele zeenwele, kunye nokulawula i-VEGF kunye nezinye i-vasoactive agents, ngaloo ndlela iphucula i-alopecia ye-androgenetic. Izifundo ezilindelekileyo ziye zafumanisa ukuba izigulane ezine-alopecia ye-androgenic ezingaphenduliyo kwiyeza eliqhelekileyo lonyango, ukusetyenziswa kwe-PDRN edibeneyo ne-PRP okanye i-1927nm i-thulium yonyango ye-laser ye-fractional ingaba yinto enokwenzeka. Nangona kunjalo, ubungakanani beesampulu ezinkulu zisafuneka ukuvavanya ukhuseleko.

6. Ezinye izifo zolusu:

Izigulane ezine-androgenetic alopecia zibonisa utshintsho lwe-scalp olufana nokunciphisa kunye nemithambo yegazi encinci. I-PDRN inokulawula indlela yokubonisa i-Wnt, ikhuthaze ukwanda kweenwele zeenwele, kunye nokulawula i-VEGF kunye nezinye i-vasoactive agents, ngaloo ndlela iphucula i-alopecia ye-androgenetic. Uphononongo olukhoyo lwangoku lucebise ukuba i-PDN idityaniswe ne-PRP okanye i-1927nm i-thulium yonyango lwe-laser ye-fractional inokuba yinto enokukhetha kuyo izigulane ezine-alopecia ye-androgenetic ezingaphenduli kunyango lweyeza eliqhelekileyo. Nangona kunjalo, ubungakanani besampulu ezinkulu zisafuneka ukuvavanya ukhuseleko lwayo.

Usetyenziso oluCetyisiweyo

Ukusetyenziswa kwe-PDRN kuyahluka kakhulu kwizifo ezahlukeneyo, kwaye inkqubo yesicelo esidibeneyo isanqongophele.

Okwangoku, iingxelo zeencwadi zasekhaya nezamazwe ngamazwe ze-PDRN ezibandakanya ukusetyenziswa kwe-topical, ukuhanjiswa kwe-intradermal, inaliti ye-intradermal, i-injection subcutaneous, kunye ne-injection ye-intramuscular. Ubuninzi bedosi ukusuka kanye yonke imihla ukuya kanye ngeveki, kwaye ubude bedosi busukela kwiintsuku ezininzi ukuya kwiiveki ezininzi. Nangona kunjalo, iindlela ezithile zokusetyenziswa kufuneka zilandelwe ngokungqongqo ngokwemveliso (yeziyobisi okanye isixhobo sonyango).

UKhuseleko kunye noKulumkela

1. I-PDRN inobunyulu be-DNA> 95% kwaye ayinayo iiprotheyini ezisebenzayo ze-pharmacologically okanye i-peptides, ngoko ke i-immunogenicity yayo iphantsi.
2. Izifundo ezininzi zeklinikhi ziye zaqinisekisa ukuba i-PDRN inokhuseleko oluhle kunye nokunyamezela kungakhathaliseki indlela yokulawula. Akukho zimpendulo zibalulekileyo zetyhefu okanye iziphumo ezibi kakhulu eziye zabonwa emva kokusetyenziswa kwe-topical, nangona ngamanye amaxesha iimpendulo ezithambileyo ezinje ngokuba bomvu kwesikhumba, ukurhawuzelelwa, kunye nokuluma kunokwenzeka. Ezi mpawu zidla ngokuphela ngokukhawuleza emva kokuyeka ukusetyenziswa kwechiza okanye unyango oluneempawu.
3. Kukho amathuba okuba neziganeko ezimbi ezifana ne-granulomas yomzimba wangaphandle kunye nosulelo oluthile xa i-PDRN ilawulwa ngenaliti. Ngoko ke, kufuneka kulumke xa usebenzisa eli chiza intradermally okanye subcutaneously.
4. I-PDRN ichasene nabasetyhini abakhulelweyo nabancancisayo, abo banamanxeba abosulelekileyo, kunye nabo bachasene ne-PDN.

Isishwankathelo kunye ne-Outlook

1. E-China, i-PDRN isetyenziswa ikakhulu kwi-topically kunye ne-microneedling mesotherapy. Ukunikezelwa kweempembelelo ze-PDRN ezichasayo kunye nokulungiswa kwezicubu ezikhuthaza amandla, uphando lwexesha elizayo lunokuphonononga amandla alo kwizicelo ezintsha.
2. Ngaphaya koko, izicwangciso zolawulo lwe-PDRN kunyango lweengxaki ezahlukeneyo zolusu, kubandakanya ukumisela eyona ndlela ilungileyo yolawulo, ukuphindaphindwa, kunye nokuxinana, kunye neziphumo zayo zokusebenzisana nezinye iindlela zonyango, zifuna uphando olongezelelweyo.