Izibonelelo ze-PDRN: Iziphumo zokwenyani zeSikhumba sexesha elide kunye neMpilo yeTissue 

Impendulo eKhawulezayo

Izibonelelo zePDN zithatha yonke into ukusuka ekomelezeni i-collagen ulusu olugudileyo ukuya kukhawulezisa ukuphiliswa kokwenzakala kwe-musculoskeletal. I-PDN yikhompawundi ekhethekileyo etofwayo evuselela iinkqubo zakho zokulungisa umzimba wakho, kunye nexesha elincinci lokuphumla kunye neziphumo ebezingalindelekanga ezinobuthathaka kubantu abaninzi. Qhubeka ufunda ukuze ufumane zonke iinkcukacha.

Isiqulatho

1. Intshayelelo: Yintoni PDRN?
2. IiNzuzo eziSekwe kubungqina obuphezulu be-PDRN
3. Ukusetyenziswa okuqhelekileyo kuNyango lwePDN
4. Yintoni ongayilindela ngexesha loNyango lwe-PDRN
5. Ukhuseleko kunye neempembelelo ezinokuthi zibe kho ze-PDRN
6. Imibuzo Ebuzwa Rhoqo Malunga nePDN
7. Ukuqukumbela: Ngaba iPDRN ikulungele wena?

Intshayelelo: Yintoni iPDRN?

I-PDN imele i-polydeoxyribonucleotide, kwaye yikhompawundi evela ngokwendalo, hayi iyeza okanye isihluzi sokwenziwa.

I-PDRN ivela phi?Ininzi ye-PDRN ye-medical-grade ikhutshwe kwiiseli zesidoda ze-salmon - akukho joke, ngowona mthombo uhambelanayo, ococekileyo esinawo ngoku. Icutshungulwe kakhulu ukuze isuse naziphi na izinto ezimelene okanye i-DNA yangaphandle, ngoko ke ukuchasana kunqabile kakhulu. (inqaku elisecaleni: Bendingazi ukuba isuka phi xa ndiqala ukufunda ngayo ngo-2021, lonto yandiphazamisa ingqondo.)

Isebenza njani iPDRN emzimbeni? Isebenza njengesichumiso kwiiseli zakho, akunjalo? Ibophelela kwii-receptors zokukhula ezikhaba iindlela zokulungisa umzimba wakho kwigiya eliphezulu.Cinga njengokutsiba-ukuqala ingca efileyo-awuhlali nje ubeka isoyi entsha (njenge-filler), wondla umhlaba ukuze ingca yakho ikhule ibuyele ebugqimeni kwaye isempilweni. Yiyo loo nto ingundoqo yokuba kutheni izibonelelo ze-PDRN zihlala ixesha elide, kungekhona okwethutyana.

Kwiminyaka yam eli-11 ndisebenza kunye neyeza lezondlo kunye ne-aesthetic regenerative, ndiyibonile i-PDRN isuka kunyango lwe-niche eyaziwa kancinci iye kwinto eninzi yezigulana zam eziyicelayo ngegama. Kodwa linda, ndiya phambili-makhe sicazulule ezona ncedo zisekwe kubungqina bePDRN kuqala.

IiNzuzo eziSekwe kubungqina obuphezulu be-PDRN

Masiqale ngezinto ezixhaswe kuphando, hayi nje i-influencer hype. Uphononongo lwe-2023 oluphuma kwi-Journal ye-Cosmetic Dermatology ekhokelwa nguDkt Elena Rossi ijonge izigulane ze-62 ezifumana ii-injection ze-PDRN zokuguga kobuso, kwaye zifumene ukuphuculwa okubalulekileyo kuzo zonke iziphumo esizikhathalelayo. Makhe siphule iinzuzo ezintathu eziphezulu zePDN.

1. Ivuselela imveliso ye-collagen yokuchasana nokuguga

Le yeyona nzuzo inkulu yePDN yokusetyenziswa kwezithambiso, ngokunyaniseka. Xa i-PDRN ijojowe kwi-dermis, ivuselela i-fibroblasts - iiseli ezenza i-collagen kunye ne-elastin.Uphononongo lwe-2023 Rossi ndikhankanyile lufumene i-41% yokwanda kwe-skin collagen density emva kweenyanga ezi-3 zonyango lwe-PDRN. Kukutsiba okukhulu oko.

Ndinesigulana, uCarla, oneminyaka engama-52, utitshala webanga lesi-4 ovela eSeattle, oweza kum entwasahlobo edlulileyo (ngo-Epreli 2023) ekhangela into enokuphucula ukumila kolusu lwakhe, hayi nje ukugcwalisa imigca ethile. Wenza unyango lwe-3 PRN kwiiveki ze-8, kwaye ngokulandelelana kwakhe ngo-Agasti, wathi imigca yakhe emihle ejikeleze amehlo akhe yayiphantse yaphela, kwaye i-makeup yakhe yaqhubela phambili kakhulu. Lo ngumlingo weenzuzo zePDN.

2. Ukukhawuleza ukulungiswa kwezicubu kunye nokuphulukiswa kwenxeba

I-PDRN ekuqaleni yayiphuhliselwe ukuphiliswa kwesilonda, kungekhona i-aesthetics, ngokwenene. Inceda imithambo yegazi emitsha ikhule kwizicubu ezonakalisiweyo, ezisa ioksijini eninzi kunye nezondlo kwindawo ukukhawulezisa ukuphilisa.Uphononongo lwe-2022 kwiJournal ye-Orthopedic kunye ne-Sports Physical Therapy ifumene ii-injection ze-PDRN zinqumle ixesha lokubuyisela iinyembezi ezincinci zemisipha malunga ne-30% xa kuthelekiswa nonyango oluqhelekileyo.

Ndibone esi sandla sokuqala kunye nesinye isigulana, uMarcus, oneminyaka engama-28, imbaleki yomgama omde osuka eDenver oqwenge isihlunu sakhe sethole ekwindla yokugqibela (ngoSeptemba 2022). Wayejonge iiveki ze-12 zokubuyisela ngonyango nje lomzimba, kodwa wongeza ii-injection ze-PDRN, kwaye wabuyela ekuqhubeni iiveki ze-50 yeekhilomitha kwiiveki ze-8. Ukwahlukana kwexesha elikhulu, akukho mbuzo.

3. Ukunciphisa ukuvuvukala kunye nokuphucula ukuthungwa kwesikhumba

I-PDRN ivimba i-cytokines e-pro-ukudumba, eyiamolekyuli ezincinci ezibangela ububomvu, ukudumba, kunye ne-bumpy engalinganiyo yesikhumba uninzi lwethu silufumana njengoko sibudala. Ilunge ngakumbi kubantu abane-rosacea okanye i-post-acne scarring, eneneni.

Yima, mandibelane ngempazamo endayenzayo ngo-2021, xa ndandiqala ukunika iPDRN. Ndacinga ukuba inzuzo ye-PDRN yayikuphela kokuvuselela i-collagen enzulu, ngoko andizange ndicinge ukuyicebisa kumzala wam uLila oye waphikelela ngokwenene i-rosacea ebomvu ezidleleni zakhe.Emva kweenyanga ezimbalwa wafumana unyango lwe-PDRN komnye umnikezeli kwaye ubomvu bakhe behla nge-70%. Ndazikhaba-ndiphoswe ngokupheleleyo ukuba enye yeenzuzo eziphambili ze-PDRN kukunciphisa ukuvuvukala. Ufunde kabuhlungu eso sifundo!

Ukusetyenziswa okuqhelekileyo kuNyango lwePDN

Okwangoku, ezona zinto zisetyenziswayo zimbini zixhaphakileyo zePDN zilungelelaniswa ngokugqibeleleyo nezibonelelo eziphezulu zePDN esisandula kuthetha ngazo. Masiziqhawule.

1. Iinkqubo zokuvuselela ulusu lwe-Cosmetic

Yiloo nto abantu abaninzi abayifunayo xa bebuza malunga neenzuzo zePDN. Ukusetyenziswa okuqhelekileyo kwezithambiso kubandakanya: -Ukuvuselelwa kobuso kumgangatho wolusu lulonke kunye nemigca emihle-Ukuphucula ukuthungwa kwamaqhakuva kunye nokubomvu kwasemva kokudumba-Ukunciphisa ububomvu obunxulumene ne-rosacea kunye nokudumba-Ukunyusa iziphumo emva kokuvuselelwa kwe-laser okanye iipeli zekhemikhali.

Ndiqale ngokwam ukufumana unyango lwe-PDRN kulo nyaka uphelileyo, emva kokuba ujongo lwam lonyaka lubonise umonakalo owenziwe lilanga ezidleleni zam. Ndiya kumntu osebenza naye ePortland, sebenzisa i-brand Rejuran, eyona nto ifundwe kakuhle kwi-PDRN phaya. Ndenze unyango lwe-3 kwiiveki ezi-3 ngaphandle, kwaye ukuthungwa kwesikhumba sam kulungele kakhulu kunokuba kwakunjalo kwiinyanga ze-12 ezidlulileyo.Ndade ndibe novavanyo lwegazi (sivavanya iimpawu zokuvuvukala kumsebenzi wam wonyaka) kunye neprotheni yam ye-C-reactive yehla ukusuka kwi-2.1 mg / L ukuya kwi-1.2 mg / L, ehambelana naloo nzuzo yokuchasana nokudumba kwe-PDRN endithethe ngayo ngaphambili. Kulungile, akunjalo?

2. Ukubuyiselwa kokulimala kwe-musculoskeletal

Le yeyona nto ithethwa kancinci malunga nokusetyenziswa, kodwa izibonelelo zePDN apha zinomtsalane, ngokoluvo lwam. Ngokuqhelekileyo isetyenziselwa: - I-Minor to moderate muscle kunye neenyembezi ze-tendon - I-Tendinitis (efana ne-tennis elbow okanye idolo lomgijimi) - Ukukhawuleza ukubuyiswa emva kokuhlinzwa kwamathambo - Ukunciphisa ukuvuvukala okungapheliyo kukulimala ngokugqithisileyo

Ndakhankanya uMarcus umgijimi ngaphambili, kodwa ndibe nezigulane ezine-elbow ye-tennis engapheliyo eyafumana i-PDRN injections kwaye yakwazi ukuyeka ukuthatha i-anti-inflammatories yonke imihla emva kweeveki ze-6. Oko kutshintsha ubomi kubantu abaninzi.

Yintoni ongayilindela ngexesha loNyango lwe-PDRN

Ukuba ucinga ngokuzama i-PDN, mhlawumbi uyazibuza ukuba anjani amava okwenene. Makhe ndikuhambise kuyo.

1. Inkqubo yonyango eqhelekileyo yePDN

Okokuqala, umboneleli wakho uya kucoca indawo yonyango kwaye ngokuqhelekileyo afake i-topical numbing cream kwimizuzu engama-20-30 ngaphambi kokutofa, ukukugcina ukhululekile.Kunyango lobuso, i-PDRN itofwe njengoluhlu lweedosi ezincinci ezincinci kuyo yonke indawo yonyango - uhlobo olufana nonyango lwe-mesotherapy. Ngenaliti ye-musculoskeletal, itofwa ngokuthe ngqo kwizicubu ezonzakeleyo kunye nesikhokelo se-ultrasound rhoqo.

Ukuqeshwa okupheleleyo, ukusuka ekubalweni ukuya ekugqibeleni, kuthatha ngaphantsi kweyure, ngokwesiqhelo. Akukho kuhlala ubusuku bonke, akukho anesthesia jikelele. Yinkqubo ese-ofisini onokuyifumana ngexesha lesidlo sasemini, ngokunyaniseka.

2. Iziphumo ezilindelekileyo kunye nexesha lokubuyisela

Ixesha lokuphumla lincinci kakhulu kunyango lwe-PDRN, enye inzuzo enkulu ye-PDRN ethandwa ngabantu. Kwizitofu zobuso, unokuba namaqhuma amancinci amancinci okanye ukugruzuka okuncinci iintsuku ezi-1-2, yiloo nto. Abantu abaninzi banokubuyela emsebenzini ngosuku olulandelayo kunye ne-concealer encinci.

Iziphumo azenzeki ngobusuku, nangona-khumbula, i-PDRN ivuselela umzimba wakho ukuba wenze izicubu ezitsha, ukuze oko kuthatha ixesha. Ngeenzuzo zobuso be-PDRN, uya kuqala ukubona ukuphuculwa okufihlakeleyo kwiiveki ze-2-3, kunye neziphumo ezipheleleyo emva kweenyanga ezi-3. Ukubuyisela ukulimala, abaninzi abantu baqala ukuva intlungu encinci kwiiveki ze-1-2, kunye nokuphucula ngokupheleleyo kwiiveki ze-4-6.

Ukhuseleko kunye neempembelelo ezinokuthi zibe kho ze-PDRN

Ngoku, asikwazi ukuthetha ngeenzuzo zePDN ngaphandle kokunyaniseka malunga nokhuseleko, akunjalo? Loo nto ayithethiswa kum.

1. Iziphumo ebezingalindelekanga eziqhelekileyo ezilindelekileyo

Phantse zonke iziphumo ebezingalindelekanga zePDN zithambile kwaye zihamba zodwa kwiintsuku ezimbalwa. Zibandakanya: - Ububomvu bexeshana kwiindawo zokutofa - Ukugruzuka kancinci okanye ukudumba - Ukurhawuzelelwa kancinci okanye ukuthamba usuku okanye ezimbini

Iziphumo ebezingalindelekanga ezimandundu ezifana nosulelo okanye ukuchasana nomzimba zinqabile kakhulu - ngaphantsi kwe-0.1% yezigulana kuphononongo luka-2023 lwe-Rossi zinalo naluphi na uhlobo lokusabela olufuna unyango. Leyo yindlela ekhuseleke ngakumbi kunolunye unyango olutofwayo, ngokunyaniseka.

2. Ngubani omele aphephe unyango lwe-PDRN

Nangona iinzuzo ezinkulu ze-PDRN, akuyena wonke umntu. Ufanele ugweme unyango lwe-PDRN ukuba: - Ngaba ukhulelwe okanye uncancisa (asinayo idatha yokhuseleko eyaneleyo apha, ngoko ikhuselekile kangcono kunokuba uxolo) - Yiba ne-allergy eyaziwayo kwi-salmon okanye nawaphi na amacandelo enaliti - Yiba nosulelo olusebenzayo kwindawo yonyango - Yiba ne-immune system okanye kwi-dose ephezulu ye-immunosuppressant

Ukuba unazo naziphi na iimeko zempilo ezingapheliyo, soloko uthetha nomboneleli wakho wokhathalelo oluphambili phambi kokuba ufumane naluphi na unyango olutsha olutofwayo, i-PDRN ibandakanyiwe.

Imibuzo Ebuzwa Rhoqo Malunga nePDN

Zithatha ixesha elingakanani iziphumo zonyango lwe-PDRN?

Izibonelelo ze-PDRN zihlala ixesha elide, kungekhona okwexeshana njenge-hyaluronic acid fillers, ezongeza nje ivolumu echitha ixesha elide. Kwizigulane ezininzi, iziphumo ezipheleleyo ezivela kuthotho lwe-3 PDRN zonyango zihlala iinyanga ezili-12-18. Unokufumana unyango olulodwa lwesondlo rhoqo kwiinyanga ezi-6-12 emva koko ukugcina izibonelelo ziqhubeka. Le yenye yezona zinto zitsala iinzuzo zePDN - uyakha uphuculo lwexesha elide, hayi ukufumana nje ukulungiswa okwethutyana.

Mangaphi amayeza ePDRN endiwafunayo?

Uninzi lwabantu ludinga uthotho lwe-3 PDRN zonyango ezibekwe kwiiveki ezi-2-4 ngaphandle kokufumana inzuzo epheleleyo ye-PDN. Yiloo nto esetyenziswa zizifundo eziphambili, kwaye yile nto ndiyibonile isebenza kakuhle kwizigulana zam. Ukuba wenza unyango lwesondlo emva kothotho lwakho lokuqala, udinga olunye kuphela kwiinyanga ezi-6-12. Ngokulimala kwe-musculoskeletal, abaninzi abantu babona iziphumo ezipheleleyo emva kwe-injection ye-1-2, kuxhomekeke kubukhulu bomonakalo.

Ngaba i-PDRN iyafana ne-PRP?

Hayi, azifani, nangona zombini ilunyango oluhlaziyayo olukhuthaza ukulungiswa komzimba wakho. I-PRP (i-platelet-rich plasma) isebenzisa iiseli zakho zegazi ezigxininiswe kwizinto zokukhula, ngelixa i-PDRN iyikhompawundi ecocekileyo ephuma kwi-salmon ebesithetha ngayo. Iinzuzo ze-PDRN ngokwenene zihambelana ngakumbi kune-PRP kwiimeko ezininzi, kuba i-PDRN inomlinganiselo oqhelekileyo rhoqo, ngelixa i-PRP inokuhluka ngokusekelwe kwinani lakho leeseli zegazi. Uninzi lwababoneleli ngokwenene luyabadibanisa ukuze bafumane iziphumo ezingcono, kodwa ngokuqinisekileyo abayonto inye.

Ukuqukumbela: Ngaba iPDRN ikulungele wena?

Masiyigqibe le nto. Izibonelelo ze-PDRN ziyamangalisa ngokwenene xa zisetyenziselwa abantu abafanelekileyo, kwaye uphando luxhasa into endiyibonile kwikliniki yam kwiminyaka eyi-3 edlulileyo.

Ukuba ukhangele indlela engeyiyo yokuhlinzwa yokunyusa i-collagen yakho, ukuphucula ukuthungwa kwesikhumba sakho, ukunciphisa ubomvu, okanye ukukhawulezisa ukulimala kwezicubu ezithambileyo ezinenkani, i-PDRN mhlawumbi ifanelekile ukuthetha nomboneleli oqeqeshiweyo malunga.Iimpembelelo zecala zincinci, ixesha lokuphumla lincinci, kwaye iziphumo zexesha elide, eziyimpumelelo kwincwadi yam.

ngokunyaniseka, ndandithandabuza ekuqaleni emva kwe-2021, kodwa emva kokubona iziphumo kunye nezigulane zam kwaye ndifumana inzuzo ye-PDRN ngokwam, ndingumguquki.Qinisekisa nje ukuba uye kumboneleli oqeqeshiweyo, onamava, kwaye ungesabi ukubabuza malunga namava abo kunye ne-PDRN ngaphambi kokuba ubhukishe. Leyo yeyona ndlela ilungileyo yokuqinisekisa ukuba ufumana izibonelelo ezipheleleyo zePDN ngokukhuselekileyo.

Kulungile? Ayinguye wonke umntu, kodwa kumntu ofanelekileyo, lutshintsho olupheleleyo lomdlalo.