
2026-09-29
45S5 I-Bioactive Glass Powder ukwakheka okukhethekile kwengilazi ye-silicate (45% SiO2, 24.5% Na2O, 24.5% CaO, kanye ne-6% P2O5 ngesisindo) eyenzelwe ukuhlangana nethambo eliphilayo nezicubu ezithambile. Njengomhlinzeki okhethekile wezinto ezingavuthiwe ezisebenza kahle kakhulu, I-Jinan Meiyi Biotechnology Co., Ltd. ihlinzeka ngokuhlanzeka okuphezulu, impushana engu-45S5 eyenziwe nge-micronized yokufakelwa kwe-biomedical, izinhlanganisela zamazinyo, kanye nemithi evuselelayo. Imodeli yethu yokuhlonza yamasu isekela amalebhu e-R&D, abakhiqizi bemishini yezokwelapha, nokukhiqizwa kwesilinganiso sezimboni, iqinisekisa ukusatshalaliswa kosayizi wezinhlayiyana okungaguquki, i-stoichiometry yamakhemikhali eqinile, nokuhambisana nezindinganiso zamazwe ngamazwe ze-biocompatibility.
I-45S5 Bioglass® imele isizukulwane sokuqala sezinto eziphilayo ezikwazi ukwakha isibopho esiqinile nethambo lomsingathi. Igama elithi "45S5" lichaza ukwakheka kwamakhemikhali: 45 wt% silica (SiO2) kanye nesilinganiso se-molar esingu-5:1 se-calcium ku-phosphorus. Ngokungafani nama-biomaterials angasebenzi njenge-titanium noma i-alumina, ethembele ekulungisweni komshini, i-45S5 bioactive glass powder iqala uchungechunge oluguquguqukayo lokusabela kwendawo lapho ivezwa oketshezini lwemvelo.
Lokhu kwaziswa kwasungulwa nguSolwazi Larry Henchey eNyuvesi yaseFlorida. Namuhla, kuseyizinga legolide ocwaningweni lwe-bioactivity kanye nokusetshenziswa komtholampilo. Ifomu lempushana livumela ukuhlanganiswa okuguquguqukayo kuma-polymers, usimende, nezikafula, okwenza onjiniyela nabelaphi bakwazi ukuhlanganisa izakhiwo zemishini nezebhayoloji zemishini yokugcina yezokwelapha.
Ukusebenza kahle kwe-45S5 powder kulele ekhonweni layo eliyingqayizivele lokushintshaniswa kwe-ion okusheshayo. Lapho kuthintana noketshezi lomzimba, ama-ion e-sodium ne-calcium ayaphuma endaweni yengilazi, akhulise i-pH yendawo futhi acuphe ukuna kongqimba lwe-carbonated hydroxyapatite (HCA). Lolu ngqimba lwe-HCA lufana ngamakhemikhali nangesakhiwo nesigaba samaminerali sethambo lemvelo, lula i-osteoconduction eqondile kanye ne-osteostimulation.
Kubakhiqizi nabacwaningi, ukuqonda le nqubo kubalulekile. Izinga lokusabela lincike ezintweni ezimbalwa, okuhlanganisa:
Ukukhiqiza nokuthola impushana yengilazi ye-bioactive yezinga eliphezulu engu-45S5 kudinga ukulawula okunembile kokukhetha impahla eluhlaza, amazinga okushisa ancibilikayo, nezinqubo zokugaya. Ngo I-Jinan Meiyi Biotechnology Co., Ltd., enekomkhulu eJinan, eSifundazweni SaseShandong, sisebenza njengenkampani ephethwe yi-Pacific Kangtai Scientific Instruments (Jinan) Co., Ltd., esizinikele ocwaningweni, ekusekeleni ukuthuthukiswa, nokudayisa ubuchwepheshe be-bioactive. Nakuba singazibandakanyi ekukhiqizeni okuqondile, sisebenza njengozakwethu wokusabalalisa oqinisekisiwe wesu lokuthola usizo, osebenzisa ubudlelwano besikhathi eside bokusebenzisana nabakhiqizi abaqashelwa umhlaba wonke, nabanesitifiketi.
Imodeli yethu yokusebenza ibeka phambili ukwethembeka nokungafihli lutho. Siqinisekisa ukuthi iqoqo ngalinye lempushana engu-45S5 linamathela ku-Good Production Practices (GMP) kanye nezinhlelo zokuphatha ikhwalithi zamazwe ngamazwe. Le ndlela yokubambisana isivumela ukuthi sinikeze ukufana kwe-batch-to-batch, okubalulekile ekugunyazweni kokulawula kudivayisi yezokwelapha kanye nezinhlelo zokusebenza zobuhle.
Inqubo iqala ngezinto zokusetshenziswa ezingahlanzekile, okuhlanganisa i-silicon dioxide, i-sodium carbonate, i-calcium carbonate, ne-phosphorus pentoxide. Ukungcola okufana nezinsimbi ezinzima kufanele kuncishiswe ukuze kuvinjelwe i-cytotoxicity. Lezi zingxenye zixutshwe ngezilinganiso eziqondile futhi zincibilike emazingeni okushisa angaphezu kuka-1300°C ngozakwethu bokukhiqiza abaqinisekisiwe. Lokhu kuncibilika kwezinga lokushisa eliphezulu kuqinisekisa ukwakheka kwengilazi okulinganayo ngaphandle kwezigaba zekristalu ezingase zibeke engozini ukusebenza kwe-bioactivity.
I-Jinan Meiyi Biotechnology igcina indlela yokwelapha eneziyalo. Zonke izinto zokusetshenziswa zihlolwa okuphelele ngaphambi kokufakwa kuphothifoliyo yethu, ngemibandela yokukhetha esekelwe kudatha yokusebenza ngempumelelo, amaphrofayili okuzinza, nokuhambisana namazinga okwakhiwa kwesimanje. Siqinisekisa ukwakheka okuyisisekelo futhi siqinisekisa ukunamathela kufomula ye-45S5 ngokubuyekezwa okuqinile kwamadokhumenti kanye nokuqinisekiswa kokucaciswa kwezinga lenqwaba.
Ngemuva kokucisha nokuchotshozwa, i-glass frit iyagaywa ukuze kuzuzwe ukusabalalisa usayizi wezinhlayiyana ezithile. Sinikezela ngezinsizakalo ezenziwe ngokwezifiso ze-micronization ngenethiwekhi yethu yokuhlinzeka ukuze sihlangabezane nezidingo ezahlukahlukene zohlelo lokusebenza:
Izinhlelo zethu ezithuthukisiwe zokulawulwa kwempahla kanye nekhwalithi ziqinisekisa ukusatshalaliswa kosayizi wezinhlayiyana ezincane, kunciphisa ukuhlanganisana kanye nokwenza ngcono ukugeleza kokucutshungulwa komfula.
Iqoqo ngalinye lempushana engu-45S5 esakazwa yiJinan Meiyi Biotechnology ihlolwa kanzima ngaphambi kokukhululwa. Uhlaka lwethu lokuqinisekisa ikhwalithi lugxile emfundweni yabahlinzeki kanye nokulandelelwa kwemibhalo, okuhlanganisa:
Impahla ngayinye eluhlaza ihambisana namadokhumenti aphelele obuchwepheshe, okuhlanganisa Izitifiketi Zokuhlaziya (CoA), AmaSpredishithi Edatha Yokuphepha Okubalulekile (MSDS), kanye nezifinyezo zesimo sokulawula lapho kufanele khona.

Lapho kutholakala impushana yengilazi engu-45S5 esebenzayo ukuze isetshenziswe ezimbonini noma kwezokwelashwa, imingcele eqondile yobuchwepheshe ibalulekile ekusebenzeni komkhiqizo. Ithebula elilandelayo libonisa ukucaciswa okujwayelekile kwempushana yethu yebanga le-premium. Ukucaciswa ngokwezifiso kuyatholakala uma kucelwe amaphrojekthi akhethekile e-R&D.
| Ipharamitha | Ukucaciswa Okujwayelekile | Indlela Yokuhlola |
|---|---|---|
| Ukwakheka Kwamakhemikhali | 45% SiO2, 24.5% Na2O, 24.5% CaO, 6% P2O5 (wt%) | I-ICP-OES |
| Isakhiwo | I-Amorphous (Non-crystalline) | I-XRD |
| Usayizi Wezinhlayiyana (D50) | Okungenziwa ngendlela oyifisayo: 0.5 µm – 500 µm | I-Laser Diffraction |
| Ubumsulwa | > 99.9% | Ukuhlaziywa kweGravimetric |
| Izinsimbi Ezisindayo | < 10 ppm (Isamba) | I-ICP-MS |
| Ikilasi le-Bioactivity | Ikilasi A (Inkomba ye-Bonding > 0.5) | Ukuhlolwa kokucwiliswa kwe-SBF |
| Okuqukethwe Umswakama | <0.5% | Ukuhlaziywa kwe-Thermogravimetric |
| Ukupakisha | Iziqukathi ezivalwe ngevacuum, ezingangenwa amanzi | Ukuhlola Okubonakalayo |
Ukuguquguquka kwe-45S5 powder kwenza ukusetshenziswa kwayo kuyo yonke imikhakha ebanzi yezimboni ze-biomedical kanye nezempilo. Ukusuka ekufakweni kwamathambo kuya emikhiqizweni yokunakekelwa kwansuku zonke, ikhono lezinto ezibonakalayo lokuvuselela ukuvuselelwa kwezicubu liqhuba izinto ezintsha emikhakheni eminingi. IJinan Meiyi Biotechnology isiza amakhasimende kulo lonke elase-Asia, eYurophu, naseNyakatho Melika, ngamandla athile ekusekeleni amalabhorethri e-R&D, ukuthuthukiswa kwezinkontileka nezinhlangano zokukhiqiza (ama-CDMO), nemitholampilo yobuhle efuna izixazululo ezihlukene, ezisekelwa isayensi.
Ekuhlinzweni kwamathambo, i-45S5 powder iyisici esibalulekile ekubambeni kwe-bone graft. Ivamise ukucwiliswa ku-scaffolds enezimbotshana noma ixutshwe nama-polymers njenge-poly-L-lactic acid (PLLA) ukuze kwakheke izinto eziyinhlanganisela. Lezi zinhlanganisela zihlanganisa i-osteoconductivity yengilazi ye-bioactive namandla emishini yama-polymers, ihlinzeka ngokusekelwa kwesakhiwo ngenkathi ikhuthaza ukukhula kwamathambo amasha.
Ucwaningo lwezokwelapha lubonise ukuthi izimila ezisekelwe ku-45S5 zihlanganisa ngokushesha nethambo lokusingatha uma kuqhathaniswa nezingubo zendabuko ze-hydroxyapatite. Lokhu kunciphisa isikhathi sokutakula futhi kuthuthukisa ukuzinza kwe-implant yesikhathi eside.
Imboni yamazinyo ingomunye wabathengi abakhulu be-45S5 bioactive glass powder. Izicelo zayo zihlanganisa:
Intuthuko yakamuva yandise ukusetshenziswa kwempushana engu-45S5 ekunakekeleni amanxeba. Uma isetshenziselwa izilonda ezingapheli, njengezilonda zesifo sikashukela, izinhlayiya zeglasi zixhumana ne-exudate yesilonda ukuze zikhulule ama-ion okwelapha. Lawa ma-ion anezakhiwo ze-angiogenic, akhuthaza ukwakheka kwemithambo yegazi emisha futhi asheshise ukulungiswa kwezicubu. Ukwengeza, indawo ye-alkaline edalwe ukushintshaniswa kwe-ion ibonisa imiphumela ye-antibacterial emnene, inciphisa ingozi yokutheleleka.
Abacwaningi baya ngokuya besebenzisa i-45S5 powder njengesithwali sokulethwa kwezidakamizwa okulawulwayo. Isakhiwo esinezimbotshana sengilazi ye-bioactive singalayishwa ngama-antibiotics, izici zokukhula, noma ama-anti-inflammatory agents. Njengoba ingilazi incibilika endaweni ye-physiological, ikhulula lawa ma-ejenti okwelapha ngendlela eqhubekayo, eqondise amasayithi athile ngenkathi ngesikhathi esifanayo ikhuthaza ukuvuselelwa kwezicubu.
Emakethe enamazinga ekhwalithi ahlukahlukene, ukukhetha umhlinzeki ofanele kubalulekile ukuze umkhiqizo uphumelele. Ifilosofi yethu yokukhiqiza igxile ekunembeni, ekuhlanzekeni, nasekubambisaneni. Nakhu ukuthi kungani izinkampani zemishini yezokwelapha ezihamba phambili nezikhungo zocwaningo zikhetha i-45S5 yethu powder.
I-Bioactivity izwela kakhulu ezinguqukweni zokuqamba. Ukuchezuka ngisho no-1% kokuqukethwe kwe-silica kungasusa i-bioactive kuya ku-bio-inert. Amasistimu wethu wokuhlanganisa azenzakalelayo kanye nokuhlaziywa kwe-spectral kwesikhathi sangempela kuqinisekisa ukuthi ikhilogremu ngayinye yempushana ifana ne-45S5 stoichiometry edingekayo ukuze usebenze kahle.
Siyaqonda ukuthi usayizi owodwa awulingani wonke. Kungakhathaliseki ukuthi udinga izinhlayiya ze-nano zama-hydrogel ajovwayo noma ama-granules amaholo kumascaffold aphrintelwe i-3D, ubuchwepheshe bethu bokugaya buvumela ukulawula okunembile ekusabalaleni kosayizi wezinhlayiyana. Singalungisa amanani e-D10, D50, kanye ne-D90 ukuze ahambisane nezidingo zakho ezithile zokucubungula.
Kubakhiqizi bemishini yezokwelapha, ukuthobela imithetho kubalulekile. Sihlinzeka ngamaphakheji aphelele amadokhumenti, okuhlanganisa Izitifiketi Zokuhlaziya (CoA), AmaSpredishithi Edatha Yokuphepha Okubalulekile (MSDS), kanye namadokhumenti anemininingwane obuchwepheshe asekela amazinga okuphathwa kwekhwalithi ye-ISO 13485. Lokhu kubeka izinto ngale kusheshisa izinqubo zakho zokuhambisa ezilawulayo.
Ngokuthuthukisa uchungechunge lwethu lokunikezela kanye nokwenyusa ukusebenza kahle kokukhiqiza, sinikeza amanani ancintisanayo we-wholesale ngaphandle kokubeka engcupheni ikhwalithi. Sisekela ama-oda amancane e-R&D kanye nezinkontileka zezimboni ezinkulu, sikunikeza izigaba zamanani eziguqukayo ezikhula nebhizinisi lakho.

Ukuqonda ukuthi i-45S5 iqhathaniswa kanjani nezinye izinto eziphilayo kusiza ekwenzeni izinqumo zokukhetha ezinolwazi zezinhlelo zokusebenza ezithile. Ithebula elilandelayo ligqamisa umehluko oyinhloko phakathi kwengilazi engu-45S5 ye-bioactive, i-hydroxyapatite (HA), nezitsha zobumba ze-bioinert njenge-alumina.
| Isici | I-45S5 Bioactive Glass | I-Hydroxyapatite (HA) | I-Alumina (I-Inert) |
|---|---|---|---|
| I-Bonding Mechanism | Isibopho samakhemikhali ngesendlalelo se-HCA | I-Osteoconductive (ukuhlanganiswa okuhamba kancane) | I-Mechanical interlocking kuphela |
| Izinga Lokusabela | Fast (izinsuku) | Kancane (izinyanga) | Lutho |
| I-Osteostimulation | Phezulu (ilungisa isisho sofuzo) | Phansi | Lutho |
| Amandla Emishini | I-Brittle (evame ukusetshenziswa kuma-composites) | Brittle | Phezulu kakhulu |
| Izakhiwo ze-Antibacterial | Yebo (ngokuphakama kwe-pH) | Cha | Cha |
| I-Resorbability | Ukuqedwa okulawulwayo | I-resorption ehamba kancane kakhulu | Okungasebenziseki |
Lesi siqhathaniso sibonisa ukuthi kungani i-45S5 ivame ukuncanyelwa ezinhlelweni ezidinga ukuhlanganiswa okusheshayo nokwenziwa kusebenze kwebhayoloji, kuyilapho izitsha zobumba ezingenasici zigcinelwe amalunga anomthwalo omkhulu lapho ukuzinza kuwukukhathazeka okuyinhloko.
Ukukhetha ukucaciswa okulungile kwe-45S5 powder kuhlanganisa ukulinganisa ukusebenza kwe-bioactivity, izakhiwo zemishini, kanye nezingqinamba zokucubungula. Nansi inkomba yokukusiza ukuthi unqume okufanelekela iphrojekthi yakho.
Ngoba izinhlanganisela ze-polymer, izinhlayiya ezincane (1–5 µm) ziyanconywa ukuze kuqinisekiswe ukuhlakazeka okufanayo nokugcina ubuqotho bomshini we-polymer matrix. Izinhlayiya ezinkulu zingasebenza njengezigxili zokucindezeleka, okuholela ekuhlulekeni ngaphambi kwesikhathi.
Ngoba izikafula namasimende amathambo, ukusabalalisa okubanzi noma ama-granules amakhulu (100-300 µm) angase abe nenzuzo ukuze enze i-porosity, evumela ukungena kwemithambo yegazi kanye nokuthutha izakhi.
Uma isicelo sakho sibandakanya imijovo noma ukuthintana ngqo nezicubu ezibucayi, khetha ibanga lethu lokuhlanzeka okuphezulu kakhulu elinemikhawulo eqinile yensimbi esindayo. Ngoba imikhiqizo yokunakekelwa kwamanxeba yangaphandle noma amadivaysi angafakeki, i-powder yebanga lezokwelapha ejwayelekile inikeza isisombululo esingabizi ngaphandle kokuyekethisa ukuphepha.
Cabanga ukuthi impushana izocutshungulwa kanjani. Uma usebenzisa Ukuphrinta kwe-3D ubuchwepheshe obufana ne-stereolithography (SLA), impushana kufanele ihambisane nesistimu ye-resin futhi ibe nezindawo eziphansi zokusabalalisa ukukhanya. Ngoba ukuncibilika noma i-sintering, ukuzinza kwe-thermal kanye ne-particle packing density yizici ezibalulekile.
Ukugcinwa okufanele kubalulekile ukuze kugcinwe ikhwalithi kanye ne-bioactivity ye-45S5 powder. Ngenxa ye-reactivity ephezulu, impahla iyi-hygroscopic futhi ingehlisa izinga uma ivezwe kumswakama.
Yebo, ingilazi engu-45S5 ye-bioactive inomlando obanzi wokusetshenziswa emtholampilo futhi yaziwa kabanzi njenge-biocompatible futhi iphephile. Isetshenziswe ezinkulungwaneni zezinqubo zokuhlinzwa emhlabeni wonke zokuvuselela amathambo kanye nezicelo zamazinyo. Kodwa-ke, njenganoma iyiphi impahla yezokwelapha, kufanele icutshungulwe futhi ibulawe amagciwane ngokuvumelana neziqondiso ezifanele zokulawula ngaphambi kokufakwa.
Uma igcinwe ephaketheni lokuqala, elingavuliwe, elivalwe nge-vacuum ngaphansi kwezimo ezinconyiwe, impilo yeshalofu ye-45S5 powder ngokuvamile iyizinyanga ezingu-24. Uma isivuliwe, kufanele isetshenziswe phakathi nezinyanga eziyisi-6 futhi igcinwe ku-desiccator ukuvimbela ukumuncwa komswakamo, okungase kuqalise ngaphambi kwesikhathi ukusabela kwendawo.
Yebo, sinikeza izinketho zokupakisha eziguquguqukayo ukuze zivumelane nezidingo zakho zokuthutha kanye nokukhiqiza. Ukupakishwa okujwayelekile kuhlanganisa izikhwama ezingu-1kg, 5kg, kanye no-25kg ezivikela umswakama. Kumakhasimende ezimboni ezinkulu, singahlinzeka ngosayizi bangokwezifiso bezigubhu noma iziqukathi eziyinqwaba ezinolayini olukhethekile ukuze siqinisekise ubuqotho bomkhiqizo ngesikhathi sokuthutha.
Yebo, kunoma yisiphi isicelo sezokwelapha esifakelwayo noma esihlaselayo, ukuvala inzalo kuyisibopho. I-45S5 powder ingafakwa inzalo kusetshenziswa i-gamma irradiation noma i-ethylene oxide (EtO) igesi. I-Autoclaving (ukwenziwa inzalo yomusi) ngokuvamile akunconyelwe izimpushana ezinhle njengoba kungabangela i-agglomeration kanye nokugeleza kwamanzi ngaphambi kwesikhathi. Singaxoxa ngezivumelwano zokuvala inzalo ezihambisana nokuhamba komsebenzi wakho wokukhiqiza.
Intengo iyahlukahluka kuye ngobunkimbinkimbi benqubo yokugaya. Izimpushana ezinosayizi we-nano zidinga ukucutshungulwa okudinga amandla amaningi kanye nokulawulwa kwekhwalithi okuqinile, okuholela ezindlekweni eziphakeme ngekhilogremu ngayinye uma kuqhathaniswa namabanga amancane noma amagremu. Sihlinzeka ngezakhiwo zentengo ye-wholesale esobala ngokusekelwe kumthamo kanye nobunkimbinkimbi bemininingwane.
Sisekela amaklayenti kuzo zonke izigaba zokuthuthuka. Ngezinjongo ze-R&D, sinikeza amanani amancane aqala ku-100 amagremu. Ukuze kukhiqizwe ukuthengisa, i-MOQ yethu ye-wholesale iqala ku-25 kg, kube nekhefu elibalulekile elitholakalayo ngama-oda angaphezu kuka-100 kg noma ithani elingu-1.
Imakethe yezinto ezisebenza nge-bioactive ikhula ngokushesha. Ngo-2026, sibona ukuthambekela okukhulayo i-multifunctional biomatadium. Abacwaningi abasafuni nje ukubopha amathambo; bafuna izinto ezikwazi ukuletha izidakamizwa, ukulwa nezifo, futhi kushukumise i-angiogenesis kanyekanye. I-45S5 powder ihamba phambili kulokhu kusungulwa.
Omunye umkhuba obalulekile ukuhlanganiswa kwengilazi ye-bioactive ibe I-3D bioprinting. Ikhono lokuphrinta izikafula eziqondene nesiguli kusetshenziswa ama-inks e-bioactive afakwe ingilazi enza izinguquko emithini yomuntu siqu. Amamaki ethu empushana ashunwe kahle enzelwe lezi zindlela zokukhiqiza ezithuthukisiwe, okuqinisekisa ukukhishwa okubushelelezi kanye nokuphrinta okunokulungiswa okuphezulu.
Ngaphezu kwalokho, ukusimama kuba into esemqoka. Izinqubo zethu zokukhiqiza zenzelwe ukunciphisa ukumosha kanye nokusetshenziswa kwamandla, kuhambisane nomgomo womhlaba wonke wokuthola usizo lwezokwelashwa oluluhlaza.
Ukukhetha umthombo ofanele 45S5 I-Bioactive Glass Powder isinqumo samasu esithinta ikhwalithi, ukusebenza kahle, kanye nempumelelo yokulawula yomkhiqizo wakho wokugcina. Ngokuzibophezela kwethu ekunembeni kwamakhemikhali, ubunjiniyela bezinhlayiyana obuzenzelayo, nokulawula ikhwalithi okuqinile, I-Jinan Meiyi Biotechnology Co., Ltd. inikeza isisekelo esinokwethenjelwa emisha oyidingayo.
Kungakhathaliseki ukuthi uthuthukisa izimila zamathambo zesizukulwane esilandelayo, izinhlanganisela zamazinyo ezithuthukisiwe, noma izixazululo zenoveli zokunakekelwa kwamanxeba, i-high-purity yethu ye-45S5 powder iletha i-bioactivity engaguquki edingekayo ukuze uphumelele emtholampilo. Asibona nje umphakeli; singazakwethu wezobuchwepheshe ozinikele ekusekeleni i-R&D yakho nezinjongo zokukhiqiza ngokusebenzisa ukuqina kwesayensi nokusabela ezimakethe.
Izwa umehluko wengilazi ye-bioactive yezinga eliphezulu. Xhumana nethimba lethu labadayisi bezobuchwepheshe namuhla ukuze ucele isampula, uxoxe ngezidingo zakho zosayizi wezinhlayiyana ezithile, noma uthole ikhotheshini eyenziwe ngezifiso.
Thatha isinyathelo esilandelayo ekusungulweni kwe-biomaterial:
→ Hlola uhla lwethu olugcwele lwe-Bioactive Glass Solutions kanye Nezinsiza Zobuchwepheshe