Ukuvumelana Kochwepheshe Ngokusetshenziswa Komtholampilo Kwe-PDRN Acid Ku-Dermatology 

Eminyakeni yakamuva, i-polydeoxyribonucleic acid (PDRN) ithole ukunakwa okusabalele futhi isetshenziswa emkhakheni we-dermatology, kodwa kusenokuntuleka kokuqonda okuhlangene mayelana nokumiswa kokusetshenziswa kwayo. I-Laser Cosmetology Group ye-Chinese Medical Association's Branch of Aesthetic and Plastic Surgeons kanye ne-Medical Cosmetology Group ye-Chinese Association of Integrative Medicine ngokuhlanganyela ikhiphe "Isivumelwano Sochwepheshe mayelana Nokusebenza Komtholampilo Kwe-Polydeoxyribonucleic Acid Kwesikhumba," okuhloswe ngayo ukunikeza odokotela izeluleko zesayensi nezinjongo ukuze zibaqondise ekusebenziseni okunengqondo kwe-PD.

I-Pharmacokinetics kanye neMechanism of Action ye-PDRN

I-PDRN ikhona ku-plasma ngendlela yamahhala futhi ayibophezeli kuma-apolipoprotein e-plasma. Ukusatshalaliswa kwayo kuhlotshaniswa kahle nokugeleza kwegazi kwezicubu. Lesi sidakamizwa asinqunywanga yisibindi; wehliswa ikakhulukazi ngama-nuclease e-plasma e-plasma angaqondile noma ama-nuclease membrane weseli ukuze enze isithako esisebenzayo, i-mononucleotide. Ekugcineni, iningi lalo likhishwa emchamweni (cishe ama-65%), nenani elincane elikhishwe endle.

Ukuwohloka kwe-PDRN kukhiqiza ama-nucleotide nama-nucleosides, okuhlinzeka ngezinto ezingavuthiwe zokulungisa umonakalo we-DNA futhi kukhuthaze ngokushesha ukulungiswa kwe-DNA yeseli eyonakele nokwanda kwamaseli.

Isicelo somtholampilo se-PDRN ku-Dermatology

1. Ukupholiswa Kwenxeba

Ucwaningo lwamanje luye lwathola ukuthi i-PDRN ibamba iqhaza enqubweni yokuphulukisa isilonda kusuka kuma-engeli amaningi, okuhlanganisa ukuvimbela izimpendulo zokuvuvukala ngokweqile, ukusheshisa ukuvuselelwa kwe-epidermal kanye ne-dermal, ukukhuthaza ukufakwa kwe-collagen, nokuvuselela i-angiogenesis nezinye izici zokulawula ezifana ne-VEGF. Ezigulini zokuxhunyelelwa kwesikhumba okuzenzakalelayo, imijovo ye-PDRN ye-intramuscular, subcutaneous, noma ye-topical endaweni yenxeba ingasheshisa ukuphinda kwe-epithelialization yesilonda kanye nesikhathi sokuphulukiswa. Ngaphezu kwalokho, isicelo se-PDRN ngemva kokwelashwa kwe-laser eyingxenye ye-CO2 kungasheshisa ukuphulukiswa kwesilonda; ngakho-ke, i-PDRN ingacatshangelwa ngemuva kokwelashwa kwe-laser ablative ukukhuthaza ukuphulukiswa kwesilonda nokubuyisela umsebenzi wokuvimbela isikhumba.

2. I-Melasma kanye ne-Post-inflammatory Hyperpigmentation:

Izimbangela ezivamile ze-melasma kanye ne-hyperpigmentation yangemuva kokuvuvukala ikakhulukazi zifaka ukusebenza okungavamile kwama-melanocyte kanye nezimpendulo zokuvuvukala eziqhubekayo. I-PDRN ingakwazi ukulawula izindlela ze-kinase ne-protein kinase B ngokwenza kusebenze ukusayinda kwe-extracellular kuma-melanocyte, yehlise amazinga we-dysplastic angiotensin-related transcription factor, ivimbele ukuvezwa kwamaprotheni ahlobene ne-tyrosinase kanye ne-melanin synthesis, kanye nokunciphisa okuqukethwe kwe-melanin kuma-melanocyte. Ngokomtholampilo, i-PDRN ingacatshangwa ihlanganiswe nezinye izindlela zokwelapha ukuphazamiseka kwe-pigmentary refractory njenge-melasma noma i-post-inflammatory hyperpigmentation. 3. Ukuguga Kwesikhumba:

I-PDRN yenza i-adenosine A2A receptors isebenze noma izindlela zokuhlenga, iqondise ukugxila kwe-cyclic adenosine monophosphate (cAMP), ivimbele ama-MMP nokuphuma kwe-elastase, ilungise kabusha i-matrix engaphandle kweseli, inciphise imibimbi, ibuyisele ukunwebeka kwesikhumba, futhi ithuthukise ukuthungwa kwesikhumba. Ngaphezu kwalokho, izifundo eziningi zithole ukuthi i-PDN ingakwazi ukwehlisa amazinga ezinto ezihlukahlukene ze-pro-inflammatory ezifana ne-IL-6, IL-1β, TNF-α, ne-IL-12, futhi iqondise ukugcinwa kwezinto ezivuthayo ezifana ne-IL-10. Lokhu kubonisa ukuthi i-PDRN ingase ibambezele ngasikhathi sinye ukwenzeka nokuthuthukiswa kokuthwebula izithombe zesikhumba ngokuvimbela ukugcinwa kwe-SASP, ukuthuthukisa ukunwebeka kwesikhumba, ukuhwalala, nezimbotshana ezikhulisiwe, nokunciphisa ukulahlekelwa kwamanzi e-transepidermal, ngaleyo ndlela kubhekwane nezinkinga zokuguga kwesikhumba.

4. Ukufaka izibazi:

Kumodeli yokuphulukisa yegundane le-SD, i-PDRN itholwe yehlisa ukungena kweseli elivuvukalayo esicutshini esibazi futhi ivimbele ukwanda kwezibazi ngokweqile ngokuvimbela isisho se-HMGB-1. Ucwaningo lwezokwelapha lwamazwe ngamazwe zithole ukuthi ukusetshenziswa kwangaphambi kwesikhathi kwe-PDRN ngemva kwe-thyroidectomy kungathuthukisa kakhulu ukuthungwa, umbala, nobukhulu bezibazi ze-hypertrophic, ngokuphepha okuhle futhi akukho ukusabela okubi. Ngakho-ke, ukungenelela kusenesikhathi nge-PDRN kungacatshangelwa amanxeba asengozini yokulimala. Njengamanje, azikho izifundo ngokusebenza kwe-PDRN kuma-keloids.

5. I-Androgenetic Alopecia:

Iziguli ezine-androgenetic alopecia zibonisa izinguquko ze-scalp njengemithambo yegazi encishisiwe kanye ne-miniaturized. I-PDRN ingakwazi ukulawula indlela yokubonisa i-Wnt, ikhuthaze ukwanda kwezinwele zezinwele, futhi iqondise i-VEGF namanye ama-vasoactive agents, ngaleyo ndlela ithuthukise i-alopecia ye-androgenetic. Ucwaningo olulindelekile luye lwathola ukuthi ezigulini ezine-androgenetic alopecia ezingaphenduli ekwelashweni kwezidakamizwa okuvamile, ukusetshenziswa kwe-PDRN kuhlanganiswe ne-PRP noma i-1927nm thulium yokwelashwa kwe-laser ye-fractional kungase kube inketho engenzeka. Nokho, amasampula amasayizi amakhulu asadingeka ukuze kuhlolwe ukuphepha.

6. Ezinye Izifo Zesikhumba:

Iziguli ezine-androgenetic alopecia zibonisa izinguquko ze-scalp njengemithambo yegazi encishisiwe kanye ne-miniaturized. I-PDRN ingakwazi ukulawula indlela yokubonisa i-Wnt, ikhuthaze ukwanda kwezinwele zezinwele, futhi iqondise i-VEGF namanye ama-vasoactive agents, ngaleyo ndlela ithuthukise i-alopecia ye-androgenetic. Ucwaningo lwamanje oluzoba khona luphakamise ukuthi i-PDN ehlanganiswe ne-PRP noma i-1927nm thulium yokwelashwa kwe-laser ye-fractional ingase ibe inketho engaba khona ezigulini ezine-alopecia ye-androgenetic ezingaphenduli ekwelashweni kwezidakamizwa okuvamile. Nokho, amasampula amasayizi amakhulu asadingeka ukuze kuhlolwe ukuphepha kwawo.

Ukusetshenziswa Okunconyiwe

Ukusetshenziswa kwe-PDRN kuyahlukahluka kakhulu kuzo zonke izifo ezihlukene, futhi iphrothokholi yesicelo esihlanganisiwe isashoda.

Njengamanje, izincwadi zasekhaya nezamazwe ngamazwe zibika izindlela zokuphatha ze-PDRN ezihlanganisa ukusetshenziswa kwe-topical, ukulethwa kwe-intradermal, umjovo we-intradermal, umjovo ongaphansi kwesikhumba, kanye nomjovo we-intramuscular. Amafrikhwensi emithamo asukela kanye ngosuku kuye kanye ngesonto, futhi ubude bemithamo busukela ezinsukwini ezimbalwa kuye emavikini ambalwa. Kodwa-ke, izindlela ezithile zokusebenzisa kufanele zilandelwe ngokuqinile ngokuya ngesigaba somkhiqizo (isidakamizwa noma isisetshenziswa sezokwelapha).

Ukuphepha Nezinyathelo Zokuqaphela

1. I-PDRN inokuhlanzeka kwe-DNA> 95% futhi ayiqukethe amaprotheni asebenzayo ekhemisi noma ama-peptide, ngakho-ke i-immunogenicity yayo iphansi.
2. Ucwaningo oluningi lwemitholampilo luphinde lwaqinisekisa ukuthi i-PDRN inokuphepha okuhle nokubekezelelana kungakhathaliseki ukuthi umzila wokuphatha. Akukho ukusabela okunobuthi okuphawulekayo noma ukusabela okubi okungathi sína okuye kwabonwa ngemva kokusetshenziswa kwesihloko, nakuba ukusabela okungekuhle ngezikhathi ezithile okufana nokuba bomvu kwesikhumba, ukulunywa, nokuluma kungase kwenzeke. Lezi zimpawu zivame ukudamba ngokushesha ngemva kokuyekiswa komuthi noma ngokwelashwa okunezimpawu.
3. Kukhona ithuba lezehlakalo ezingezinhle ezifana ne-granulomas yomzimba wangaphandle kanye nezifo ezithile lapho i-PDRN ilawulwa ngomjovo. Ngakho-ke, ukuqapha kufanele kusetshenziswe lapho usebenzisa lesi sidakamizwa nge-intradermally noma ngaphansi kwesikhumba.
4. I-PDRN iphikisiwe kwabesifazane abakhulelwe nabancelisayo, labo abanezilonda ezithelelekile, nalabo abangezwani ne-PDRN.

Isifinyezo kanye ne-Outlook

1. E-China, i-PDN isetshenziswa ngokuyinhloko ngokwezihloko nange-mesotherapy ye-microneedling. Njengoba kunikezwe imiphumela ye-PDRN yokulwa nokuvuvukala kanye nekhono lokuthuthukisa izicubu, ucwaningo lwesikhathi esizayo lungahlola amandla alo ezinhlelo zokusebenza ezintsha.
2. Ngaphezu kwalokho, amasu okuphatha e-PDRN ekwelapheni izinkinga ezihlukahlukene zesikhumba, okuhlanganisa nokuthola indlela efanele yokuphatha, imvamisa, nokugxilisa ingqondo, kanye nemiphumela yayo yokusebenzisana nezinye izindlela zokwelapha, kudinga uphenyo olwengeziwe.