Izigaba Ezingu-5 Eziyinhloko Eziyinhloko Zenqubo Yesimanje Yokukhiqiza Izinto Ezingavuthiwe ze-PDRN 

Impendulo esheshayo

I-PDRN Raw Material Production Process ishintsha izicubu zomthombo ezigunyaziwe zibe i-deoxyribonucleotide polymer ehlanzekile, esebenza ngokwebhayoloji esetshenziswa ekunakekelweni kwesikhumba kwezokwelapha nezimonyo. Zonke izinyathelo zithinta ukuphepha nokusebenza kahle kokugcina, ngakho ukulawulwa kwekhwalithi okuqinile akunakuxoxiswana ngakho kusukela ekuqaleni kuya ekugcineni.

Uhlu Lokuphakathi

1. Isingeniso se-PDRN Raw Material
2. Amazinga Abalulekile we-PDRN Raw Material Sourcing
3. Isinyathelo Ngesinyathelo Inqubo Yokukhiqiza Izinto Ezingavuthiwe ze-PDRN
4. Ukulawulwa Kwekhwalithi Nezidingo Zokuhlanza
5. Izinselelo Ezijwayelekile Ekukhiqizeni kwe-PDN
6. Imibuzo Evame Ukubuzwa (FAQ)
7. Isiphetho

Isingeniso ku I-PDN I-Raw Material

I-PDN imele i-polydeoxyribonucleotide, iyi-biopolymer eyenziwe ngezingcezu ze-DNA ezimfushane edume kakhulu njengamanje ekuvuseleleni isikhumba kanye nokuphulukiswa kwesilonda.

Ikhwalithi yezinto ezingavuthiwe yiyo yonke into lapha. Uma usika amakhona ku-PDRN Raw Material Production Process, ugcina usunomkhiqizo ongasebenzi - noma okubi nakakhulu, ongaphephile.

Isetshenziselwa ini, noma kunjalo? Izicelo zezokwelapha zihlanganisa ukuphulukiswa kwenxeba lesifo sikashukela kanye nokulungisa izicubu ezithambile ngemva kokuhlinzwa.

Ngobuhle, uzoyithola kuma-booster esikhumba ajovayo kanye nama-serum e-topical akhulisa ukukhiqizwa kwe-collagen futhi afiphale imigqa emihle. Ngisebenze nomnikazi we-spa yezokwelapha e-Miami, e-Lena, emuva ngo-March 2023 owayenemiphumela emibi evela kubheshi eshibhile ye-PDRN - wangitshela ukuthi ingxenye yamakhasimende akhe ayizange ibone izinguquko nhlobo. Kuvela ukuthi umkhiqizi weqe izinyathelo ezibalulekile kunqubo ye-PDRN Raw Material Production. Alikho ihlaya.

Amazinga Abalulekile we-PDRN Raw Material Sourcing

Linda, asenze ikhophi yasenqolobaneni ngaphambi kokuthi singene Kunqubo Yangempela Yokukhiqiza Okungavuthiwe ye-PDRN. Konke kuqala ngokuthungatha. Awukwazi ukwenza i-PDRN enhle ngezinto ezingavuthiwe ezimbi.

Yiziphi izinto zomthombo ezigunyaziwe zokukhiqiza ukuthengisa? I-99% yekhwalithi ephezulu ye-PDRN esemthethweni ivela kuzicubu zesidoda se-salmon efuywayo. Uhlobo olumangazayo, akunjalo?

Eminye imithombo egunyaziwe ihlanganisa i-trout, kodwa i-salmon ivame kakhulu ngoba kulula ukuyikhipha njalo.

Izidingo zokulawula ziqinile impela. I-EU kanye ne-FDA zidinga i-salmon yomthombo ukuthi ikhuliswe emapulazini agunyaziwe, angenazo izifo, anokulandeleka okugcwele kweqoqo ngalinye.

Zonke izinhlanzi kufanele zihlolelwe izinsimbi ezisindayo, amagciwane, kanye nokungcola kwemvelo ngaphambi kokuthi zingene ku-PDRN Raw Material Production Process. Lokho akukhona inketho.

Isinyathelo Ngesinyathelo Inqubo Yokukhiqiza Izinto Ezingavuthiwe ze-PDRN

Manje ake sidlule ku-PDRN Raw Material Production Inqubo yesinyathelo nesinyathelo. Cabanga ngalokhu njengokubhaka ikhekhe - ngcolisa isinyathelo esisodwa, yonke into iwela phansi.

Ukukhishwa kokuqala kanye nokucubungula okuyinhloko

Okokuqala, izicubu zesidoda ziyahlukaniswa kwezinye izicubu zezinhlanzi futhi zigezwe kahle ukuze kukhishwe igazi, amafutha nokunye ukungcola. Khona-ke, izicubu zihlanganiswa zibe i-slurry, futhi i-DNA ikhishwa ku-nuclei yeseli kusetshenziswa i-enzymatic lysis emnene.

Lesi sinyathelo kufanele silawulwe kakhulu. i-enzyme eningi futhi uphula i-DNA kude kakhulu, kancane futhi awutholi isivuno esanele. Ngibone umkhiqizi waseNingizimu Korea engcolisa lokhu emuva ngo-2021 - banqamula isikhathi sokwelashwa kwe-enzyme phakathi ukuze bakhule ngokushesha, futhi bagcina bene-PDRN emsulwa engaphansi ngo-30% ngeqeqebana ngalinye. Lokho ukulahlekelwa okukhulu.

Ukuhlukaniswa nokulungiswa kosayizi wamangqamuzana

Lesi isinyathelo sokwenza noma sekhefu se-PDRN Raw Material Production Process. I-PDRN idinga izingcezu ze-DNA ezimfushane, ezifanayo ukuze zisebenze kahle emzimbeni. Ngemuva kokukhipha okokuqala, izintambo ezinde ze-DNA zisikwa zibe izingcezu ezincane kusetshenziswa i-enzymatic hydrolysis elawulwayo noma ukuhlukaniswa kwe-ultrasonic.

Izinqubo eziningi zekhwalithi ephezulu zikhomba izingcezu eziyisisekelo eziphakathi kuka-50 no-2000, okuboniswe ukuthi kunomsebenzi webhayoloji ongcono kakhulu. Cabanga ngalokhu njengokusika isihlahla esikhulu sibe yizinkuni ezilingana ngokufanayo - sikhulu kakhulu futhi ngeke sishise kahle, sincane kakhulu futhi sishe ngokushesha.

Ukuvala inzalo kokugcina kanye ne-lyophilization

Uma usunezingcezu ze-PDRN ezinosayizi obufanele, sekuyisikhathi sokuhlanza noma yikuphi ukungcola okusele futhi ukhiphe amagciwane enqwaba. Ukuvala inzalo kuvame ukwenziwa ngokuhlunga okuyinyumba, hhayi ukushisa, ngoba ukushisa kungalimaza umsebenzi webhayoloji we-PDN.

Ngemuva kokuvala inzalo, isisombululo se-PDRN sifakwe iqhwa (i-lyophilized) sibe yimpuphu ezinzile engagcinwa iminyaka ngaphandle kokulahlekelwa umsebenzi. Yilokho kuphela kwe-PDRN Raw Material Production Process!

Nali ithebula elisheshayo elifingqa izinyathelo ezibalulekile:

Ukulawulwa Kwekhwalithi Nezidingo Zokuhlanza

Ukulawulwa kwekhwalithi akumi ekupheleni kwe-PDRN Raw Material Production Process. Kwenzeka kuzo zonke izigaba.

Ukuhlanzeka okuyinhloko kanye namazinga okuhlola isisindo samangqamuzana

Okokuqala, iqoqo ngalinye lihlolelwa ukusatshalaliswa kwesisindo samangqamuzana ukuze kuqinisekiswe ukuthi okungenani u-90% wezingcezu ziwela ebangeni elifanele le-base 50-2000. Ukuhlola ubumsulwa kuhlola amaprotheni ayinsalela, amafutha, nokunye ukungcola okungeyona i-DNA - i-PDRN yekhwalithi ephezulu kufanele okungenani ibe yi-DNA emsulwa engu-95%.

Ucwaningo lwango-2023 olwenziwe nguPark et al. kweIjenali ye-Cosmetic Dermatologyithole ukuthi amaqoqo e-PDRN anobumsulwa obungaphansi kuka-90% anomsebenzi ovuselela i-collagen ongaphansi ngo-40% kunamaqoqo amsulwa. lokho umehluko omkhulu, uyazi?

I-Endotoxin kanye nezinqubo zokuhlola ukuphepha

Ukuhlolwa kwe-endotoxin kuyimpoqo kunoma iyiphi i-PDRN ezosetshenziselwa umjovo. I-Endotoxins yizinto ezikhiqizwa yibhaktheriya ezingabangela ukuvuvukala okubi uma zingena emzimbeni wakho. Amazinga okulawula adinga amazinga e-endotoxin angaphansi kuka-0.5 EU/mL kuzinto ezingavuthiwe ze-PDRN ezijovwa.

Iqoqo ngalinye liphinde lihlolelwe izinsimbi ezisindayo (i-mercury, umthofu, i-arsenic) kanye namagciwane avamile njenge-salmonella ne-listeria. Uma iqoqo lehluleka noma yikuphi kwalokhu kuhlola, likhishwa ngokushesha. Akukho okuhlukile.

Izinselelo Ezijwayelekile Ekukhiqizeni kwe-PDN

I-PDRN Raw Material Production Process ayilula, kunezingibe eziningi ezivamile abakhiqizi abangena kuzo ngaso sonke isikhathi.

Ukugcina umsebenzi webhayoloji ongaguquki

Umsebenzi wezinto eziphilayo uncike ekulondolozeni ukwakheka kwemvelo kwezingcezu ze-DNA. Uma usebenzisa ukushisa okukhulu noma amakhemikhali anokhahlo kakhulu ngesikhathi sokucubungula, ulimaza izingcezu futhi ziyeka ukusebenza. Ngavakashela indawo encane yokuqalisa ngaphandle kwaseVancouver emuva ngo-2022 eyayinenkinga nalokhu - wonke amanye amaqoqo ayenomsebenzi ongahambisani, futhi abakwazanga ukuthola ukuthi kungani. Kwavela umjikelezo wabo we-lyophilization ushisa kakhulu, futhi wawuphula i-DNA.

Kuyisenzo sokulinganisa esibucayi, ngokweqiniso. Kufanele uhlanze ngokwanele ukuze ukhiphe ukungcola, kodwa hhayi kakhulu kangangokuthi ucekela phansi into ozama ukuyenza.

Ukulinganisa isikali sokukhiqiza kanye nekhwalithi yezinto ezingavuthiwe

Lapho isidingo se-PDRN siqhuma eminyakeni embalwa edlule, abakhiqizi abaningi bazama ukukhuphula ngokushesha okukhulu ngokusika amakhona ekutholeni nasekucubunguleni. Baqala ukusebenzisa i-salmon efuywayo yekhwalithi ephansi, noma ukweqa izinyathelo ezimbalwa zokuhlanza ukuze bakhiphe umkhiqizo owengeziwe ngokushesha. Uthola kanjalo lawo maqoqo amabi engikhulume ngawo ekuqaleni noLena ongumnikazi we-spa.

Inselele enkulu njengamanje ukugcina I-PDRN Raw Material Production Process ingashintshi ngisho nalapho ukhiqiza ama-batch angu-10x amaningi kunaweminyaka engu-3 edlule. Kufana nokuzama ukugcina i-pizza crisp uma usuka ekwenzeni ezingu-10 ngobusuku ukuya kweziyi-100 ngobusuku—iresiphi ayishintshi, kodwa kufanele ulungise inqubo yakho ukuze ugcine ikhwalithi iphezulu.

Imibuzo Evame Ukubuzwa (FAQ)

Ingabe i-PDRN impahla eluhlaza etholakala esicutshini sesilwane iphephile?

Uma i-PDRN Raw Material Production Process ilandela yonke imihlahlandlela yokulawula, yebo, iphephe kakhulu. Wonke ama-salmon omthombo ogunyaziwe afuywa ezindaweni ezilawulwa izifo, ezihloliwe, futhi zonke izinyathelo zokukhipha nokuhlanzwa ziqeda noma yiziphi izifo ezingaba khona noma ukungcola. Akukaze kube necala elibhaliwe lokudluliselwa kwezifo kusuka ku-PDRN ecutshungulwe kahle. Ubungozi obukhulu buvela kubakhiqizi abangalawulwa abeqa ukuhlolwa kokuphepha ukuze banciphise izindleko. Njalo thola kumnikezeli ohlinzeka ngokuhlolwa okuphelele kokuphepha kwenkampani yangaphandle kuyo yonke inqwaba.

Isiphi isisindo semolekyuli esifanele sekhwalithi ephezulu ye-PDRN impahla eluhlaza?

Amashumi eminyaka ocwaningo lomtholampilo nge-PDRN Raw Material Production Process ikhombisa ububanzi besisindo semolekyuli buphakathi kuka-50 kDa no-300 kDa, okusho ukuthi cishe amapheya ayisisekelo angama-50 kuye kwangama-2000. Lobu bukhulu buncane ngokwanele ukuba bungene kalula esicutshini sesikhumba, kodwa bukhulu ngokwanele ukugcina umsebenzi webhayoloji okhuthaza ukukhula kwamangqamuzana nokukhiqizwa kwe-collagen. Isilingo somtholampilo sango-2022 esishicilelwe kuUkulungisa Amanxeba Nokuvuselelwa Kabushaithole ukuthi i-PDN ngaphandle kwalolu bubanzi inciphise kakhulu umsebenzi wokuvuselela. Noma yimuphi umphakeli onedumela elihle uzokwabelana nawe ngokuhlolwa kwesisindo samangqamuzana ngaphambi kokuthenga.

Ingabe ukukhiqizwa kwe-PDRN kuhluke kanjani kwezinye izithako zezimonyo ezisekelwe ku-DNA?

Umehluko omkhulu kakhulu umthombo kanye ne-PDRN Raw Material Production Process. Iningi lezinye izithako zezimonyo ezisekelwe ku-DNA zenziwe nge-DNA yezitshalo noma izingcezu ze-DNA zokwenziwa, kuyilapho i-PDRN cishe njalo itholakala esidodeni se-salmon. Inqubo yokukhipha nokuhlukanisa iphinde ilawuleke kakhulu ku-PDRN, ikakhulukazi ngoba isetshenziselwa kokubili imijovo yezokwelapha nezimonyo. Ezinye izithako ze-DNA ngokuvamile azidingi izinga elifanayo lokuhlolwa kwe-endotoxin noma ukungaguquguquki kosayizi we-molecular eyenziwa yi-PDRN, ngoba isetshenziswa kuphela emikhiqizweni yama-topical engaphuli umgoqo wesikhumba. Yingakho ukulawulwa kwekhwalithi kubaluleke kakhulu ekukhiqizeni i-PDRN kunezinye izithako zezimonyo ezisekelwe ku-DNA.

Isiphetho

Ake sisonge esikuhlanganise mayelana ne-PDRN Raw Material Production Process. Konke kuqala ngezinga eliphezulu, izinto zomthombo olandeleka ngokugcwele, futhi zonke izinyathelo ukusuka ekukhishweni kuye ku-lyophilization kufanele zilawulwe ngokuqinile ukuze kulondolozwe umsebenzi webhayoloji nokuqinisekisa ukuphepha.

Ukuvumelana yigama lomdlalo. Abakhiqizi abangcono kakhulu abanqamuli amakhona ukuze bakhule ngokushesha, batshala imali ekulawuleni ikhwalithi kuzo zonke izigaba ze-PDRN Raw Material Production Process.

Uma uthenga impahla eluhlaza ye-PDN yebhizinisi lakho, hlala ucela imiphumela yokuhlola egcwele yawo wonke amaqoqo. Ungathathi nje izwi lomphakeli ngakho. Ngifunde lokhu kabuhlungu ngo-2020 lapho ngincoma umphakeli oshibhile eklayentini, futhi bagcina benenqwaba embi ebangele ukuvuvukala okuncane ezigulini ezimbalwa. Ngeke ngiphinde.

Ekupheleni kosuku, ikhwalithi yomkhiqizo wakho wokugcina we-PDN yinhle kuphela njenge-PDRN Raw Material Production Process ewudalile. Kulula kanjalo.