I-recombinant human superoxide dismutase (rhSOD): Impumelelo entsha emkhakheni wama-antioxidants anikwe amandla yi-biotechnology. 

Imizimba yethu ngokwemvelo ikhiqiza i-superoxide dismutase (SOD), kodwa izinselele eziningi zempilo yesimanje zingaphezu kwamandla ayo. Ukwengeza nge-SOD akuyona nje inzuzo eyengeziwe, kodwa kunalokho ukuqiniswa okudingekayo komzimba. Ukukhethwa kwesengezo se-SOD, nokho, kunquma ukusebenza kahle nokuphepha kwalokhu kuqiniswa.

Ngaphambi kokuba sixoxe ngokuthi “yini okumele yengezelelwe,” kufanele siqale siqonde ukuthi “kungani kudingeka senezele.” Lokhu akukhona nje ngobuhle, kodwa futhi mayelana nezimiso eziyisisekelo zempilo.

Kungani kudingekile ukwengeza nge-superoxide dismutase (SOD)?

Umzimba womuntu ngempela unawo "umugqa wokukhiqiza we-SOD," kodwa ngokukhula nokushintsha kwendlela yokuphila, "ibhalansi yesidingo sokuthenga" ye-SOD iyawohloka kancane kancane, okuholela ekweqiseni kwama-radicals mahhala, ukulimaza imisebenzi yomzimba kanye nokusheshisa inqubo yokuguga.

1.Ukuguga:  "Ukukhiqizwa kwe-SOD" komzimba kuyancipha, futhi amandla ayo okukhipha amanzi ayancipha.

Iminyaka engu-25 iyiphuzu elibalulekile: Ngaphambi kweminyaka engama-25, izinga lomzimba le-SOD synthesis lingakwazi "ukuhambisana" nezinga lokukhiqizwa kwama-radical mahhala; Nokho, ngemva kweminyaka engu-25, ukuhlanganiswa kwe-SOD kuncipha ngenani le-1% -2% ngonyaka. Ngeminyaka engama-40, umsebenzi we-SOD womzimba usuke usungama-50% kuphela wezinga lawo eliphakeme, futhi ngemuva kweminyaka engama-60, ungaphansi kwama-30%.

Phakathi naleso sikhathi, ukukhiqizwa kwama-radicals mahhala akunciphi—i-cell metabolism nokuphefumula kukhiqiza ama-radicals mahhala e-superoxide anion. Lokhu kuholela ku-SOD enganele, futhi ama-radicals wamahhala ngokweqile aqala ukuhlasela amangqamuzana: i-collagen yesikhumba elimazayo (ebangela imibimbi), elimaza i-vascular endothelium (ukusheshisa ukuguga kwe-vascular), kanye namaseli esibindi oxidizing (ukwandisa umthwalo we-metabolic). Lesi esinye sezizathu eziyinhloko "zokuguga."

I-2.Impilo Yesimanje: Ama-Radical Amahhala Eqile, I-SOD Enganele Ye-Endogenous

Ngaphandle kweminyaka yobudala, imikhuba yokuphila yansuku zonke iphinde isheshise ukukhiqizwa kwama-radicals mahhala:

Ukuchayeka kwe-UV: Ukuchayeka elangeni ihora elilodwa ngosuku kukhulisa ama-radicals mahhala akhiqizwa isikhumba izikhathi ezintathu, okudlula kude umthamo wokusula we-SOD (superoxide dismutase) womzimba;

Ukuhlwa ebusuku nokucindezeleka: Uma ungalali noma ucindezelekile, umzimba ukhiqiza "ama-hormone okucindezeleka," akhuthaze ukukhiqizwa kwenani elikhulu lama-radicals mahhala;

Ukudla okungenamsoco: Ukudla okunoshukela omningi, okunamafutha amaningi, nokudla okuthosiwe kukhiqiza imikhiqizo yokuphela kwe-glycation esezingeni eliphezulu ngesikhathi se-metabolism, ehambisana nenani elikhulu lama-radicals mahhala;

Ukungcoliswa kwemvelo: Izinto eziyingozi ku-smog, i-exhaust yemoto, nentuthu kagwayi, ngemva kokungena emzimbeni womuntu, kubangela "ukucindezeleka okwenziwe nge-oxidative," okuholela ekwandeni kwama-radicals mahhala;

Umthelela wezifo: Izimo ze-pathological ezibangelwa ukugula kanye nenqubo ye-metabolism yezidakamizwa zombili zikhulisa ukucindezeleka okwenziwe nge-oxidative emzimbeni, kube abashayeli ababalulekile bokusabalala okungavamile kwama-radicals mahhala.

I-3.I-SOD yomzimba ngokwayo "inamandla alinganiselwe" futhi ayikwazi ukubhekana "nokuhlaselwa okugxilile."

Ngisho nakubantu abasha abaphila ngendlela enempilo, i-SOD yomzimba siqu inemikhawulo yayo: igxile kakhulu ngaphakathi kwamangqamuzana futhi inikeza ukuvikeleka okwanele ngokumelene nama-radicals mahhala egazini nangaphezulu kwesikhumba; ngaphezu kwalokho, umsebenzi wayo awuphakeme ngokwanele ukuqeda ngempumelelo ama-radicals mahhala ngesikhathi "sokuqhuma okugxilile" (njengangemuva kokuchayeka elangeni noma ukuvivinya umzimba kanzima).

Kulapho ukugcwalisa nge-SOD kudingekile khona—kufana nokwengeza "izihlanzi ezisebenza kahle kakhulu" emzimbeni ukusiza ukususa ngokushesha ama-radicals mahhala futhi kuvimbele ukulimala kwamaseli okuqhubekayo.