Ijma'in Kwararru Akan Aikace-aikacen Clinical Na PDRN Acid A cikin ilimin cututtukan fata 

A cikin 'yan shekarun nan, polydeoxyribonucleic acid (PDRN) ya sami kulawa mai yawa da aikace-aikace a fannin ilimin fata, amma har yanzu akwai rashin fahimtar fahimtar juna game da daidaitattun aikace-aikacensa. The Laser Cosmetology Group of the Chinese Medical Association’s Branch of Aesthetic and Plastic Surgeons and the Medical Cosmetology Group of the Chinese Association of Integrative Medicine jointly issued the “Expert Consensus on the Clinical Application of Polydeoxyribonucleic Acid in Dermatology,” aiming to provide clinicians with scientific and objective advice to guide them in the rational and effective application of PDRN in practice.

Pharmacokinetics da Mechanism na Aiki na PDRN

PDRN yana wanzuwa a cikin jini a cikin sigar kyauta kuma baya ɗaure da apolipoproteins na plasma. Rarrabanta yana da alaƙa da alaƙa da kwararar jini na nama. Wannan magani ba ya daidaita ta hanta; An lalata shi ne ta hanyar ƙananan ƙwayoyin DNA na plasma marasa ƙayyadaddun ƙwayoyin cuta ko ƙwayoyin membrane na sel don samar da sinadari mai aiki, mononucleotide. Daga qarshe, ana fitar da mafi yawansa a cikin fitsari (kimanin 65%), tare da fitar da dan kadan a cikin najasa.

Ragewar PDRN yana samar da nucleotides da nucleosides, suna samar da albarkatun kasa don gyaran lalacewar DNA da sauri inganta gyaran DNA tantanin halitta da aka lalata da kuma yaduwar kwayar halitta.

Aikace-aikacen Clinical na PDRN a cikin Dermatology

1. Warkar da Rauni

Binciken na yanzu ya gano cewa PDRN yana shiga cikin tsarin warkar da raunuka daga kusurwoyi da yawa, ciki har da hana wuce kima martanin kumburi, haɓaka sabuntawar epidermal da dermal, inganta haɓakar collagen, da haɓaka angiogenesis da sauran abubuwan ka'idoji kamar VEGF. A cikin majinyatan fata na autologous, intramuscular, subcutaneous, ko Topical PDRN injections a wurin rauni na iya hanzarta sake farfadowar rauni da lokacin warkarwa. Bugu da ƙari kuma, aikace-aikacen PDRN bayan CO2 jiyya na laser juzu'i na iya hanzarta warkar da rauni; sabili da haka, ana iya la'akari da PDRN bayan jiyya na laser ablative don inganta warkar da rauni da dawo da aikin shinge na fata.

2. Melasma da Post-inflammatory Hyperpigmentation:

Dalilan gama gari na melasma da hyperpigmentation post-inflammatory galibi sun haɗa da kunnawar melanocytes na al'ada da kuma ci gaba da amsa kumburi. PDRN na iya daidaita hanyoyin kinase da furotin kinase B ta hanyar kunna siginar siginar extracellular a cikin melanocytes, rage daidaita matakan abubuwan rubutu na angiotensin da ke da alaƙa da dysplastic, hana bayyanar tyrosinase da ƙwayoyin melanin da ke da alaƙa, da rage abubuwan melanin na melanocytes. A asibiti, ana iya la'akari da PDRN a hade tare da wasu hanyoyin da za a bi da rikice-rikice na pigmentary kamar melasma ko hyperpigmentation post-inflammatory. 3. Tsufawar fata:

PDRN yana kunna masu karɓa na adenosine A2A ko hanyoyin ceto, yana haɓaka ƙaddamarwar adenosine monophosphate (cAMP) cyclic, yana hana MMPs da elastase secretion, ya gyara matrix na extracellular, yana rage wrinkles, dawo da elasticity na fata, da inganta yanayin fata. Bugu da ƙari kuma, binciken da yawa ya gano cewa PDRN na iya rage matakan matakan da ke tattare da abubuwan da ke haifar da kumburi irin su IL-6, IL-1β, TNF-α, da IL-12, da kuma daidaita abubuwan da ke haifar da kumburi kamar IL-10. Wannan yana nuna cewa PDRN na iya jinkirta abin da ya faru da kuma ci gaba da daukar hoto na fata ta hanyar hana ɓoyewar SASP, inganta elasticity na fata, rashin ƙarfi, da kuma kara girman pores, da kuma rage asarar ruwa na transepidermal, don haka magance matsalolin tsufa na fata.

4. Tabo:

A cikin samfurin warkarwa na bera na SD, an gano PDRN don rage kutsawar kwayar halitta mai kumburi a cikin tabo da hana yaɗuwar tabo ta hanyar hana magana ta HMGB-1. Nazarin asibiti na kasa da kasa sun gano cewa yin amfani da PDRN da wuri bayan thyroidectomy na iya inganta yanayin rubutu, launi, da girman hypertrophic scars, tare da aminci mai kyau kuma ba tare da wani tasiri ba. Don haka, ana iya yin la'akari da sa baki da wuri tare da PDRN don raunin da ke cikin haɗarin tabo. A halin yanzu, babu wani bincike kan ingancin PDRN a cikin keloids.

5. Androgenetic alopecia:

Marasa lafiya tare da alopecia na androgenetic suna nuna sauye-sauyen fatar kan mutum kamar raguwa da ƙananan tasoshin jini. PDRN na iya daidaita hanyar siginar Wnt, haɓaka haɓakar gashin gashi, da daidaita VEGF da sauran abubuwan vasoactive, ta haka inganta alopecia na androgenetic. Binciken da ake tsammani ya gano cewa ga marasa lafiya da alopecia na androgenetic wadanda ba su amsa maganin maganin miyagun ƙwayoyi na al'ada ba, yin amfani da PDRN tare da PRP ko 1927nm thulium thulium laser jiyya na iya zama wani zaɓi mai mahimmanci. Koyaya, har yanzu ana buƙatar manyan samfuran samfuri don tantance aminci.

6. Sauran Cututtukan Fata:

Marasa lafiya tare da alopecia na androgenetic suna nuna sauye-sauyen fatar kan mutum kamar raguwa da ƙananan tasoshin jini. PDRN na iya daidaita hanyar siginar Wnt, haɓaka haɓakar gashin gashi, da daidaita VEGF da sauran abubuwan vasoactive, ta haka inganta alopecia na androgenetic. Binciken da ake yi na yanzu ya nuna cewa PDRN hade tare da PRP ko 1927nm thulium fractional laser jiyya na iya zama zaɓi mai yuwuwa ga marasa lafiya tare da alopecia na androgenetic waɗanda ba su amsa maganin maganin gargajiya na al'ada. Koyaya, har yanzu ana buƙatar manyan samfuran samfuri don tantance amincin sa.

An Shawarar Amfani

Amfani da PDRN ya bambanta sosai a cikin cututtuka daban-daban, kuma har yanzu babu ƙa'idar aikace-aikacen haɗin gwiwa.

A halin yanzu, wallafe-wallafen cikin gida da na ƙasashen waje suna ba da rahoton hanyoyin gudanarwa na PDRN ciki har da aikace-aikacen kai tsaye, isar da intradermal, allurar intradermal, allurar subcutaneous, da alluran intramuscularly. Matsakaicin adadin sashi ya bambanta daga sau ɗaya kowace rana zuwa sau ɗaya a mako, kuma tsawon lokacin yin allurai yana daga kwanaki da yawa zuwa makonni da yawa. Koyaya, takamaiman hanyoyin amfani dole ne a bi su sosai bisa ga rarrabuwar samfur (magunguna ko na'urar likita).

Tsaro da Kariya

1. PDRN yana da tsaftar DNA> 95% kuma baya ɗauke da sunadaran sunadarai ko peptides masu aiki da magunguna, don haka immunogenicity ɗin sa yayi ƙasa.
2. Yawancin karatun asibiti sun kuma tabbatar da cewa PDRN yana da aminci mai kyau da haƙuri ba tare da la'akari da hanyar gudanarwa ba. Ba a ga wani gagarumin halayen mai guba ko munanan halayen da aka samu ba bayan aikace-aikacen kan layi, ko da yake lokaci-lokaci munanan halayen kamar jajayen fata, ƙaiƙayi, da ƙura na iya faruwa. Waɗannan alamomin yawanci suna raguwa da sauri bayan katsewar maganin ko tare da jiyya na alama.
3. Akwai yuwuwar faruwar abubuwan da ba su da kyau kamar granuloma na jikin waje da takamaiman cututtuka lokacin da ake gudanar da PDRN ta allura. Don haka, ya kamata a yi taka tsantsan yayin amfani da wannan magani a cikin fata ko kuma a cikin ƙasa.
4. An haramta PDRN a cikin mata masu ciki da masu shayarwa, masu ciwon raunuka, da masu rashin lafiyar PDRN.

Summary da Outlook

1. A kasar Sin, ana amfani da PDRN a kai a kai kuma ta hanyar microneedling mesotherapy. Idan aka ba da tasirin anti-mai kumburi na PDRN da ƙarfin haɓaka nama, bincike na gaba zai iya bincika yuwuwar sa don sabbin aikace-aikace.
2. Bugu da ƙari kuma, dabarun gudanarwa na PDRN a cikin magance matsalolin fata daban-daban, ciki har da ƙayyade mafi kyawun hanyar gudanarwa, mita, da maida hankali, da kuma tasirin sa tare da sauran hanyoyin kwantar da hankali, yana buƙatar ƙarin bincike.