Menene ainihin PDRN? Me ya sa ake yaba shi a matsayin "maɓalli don maganin farfadowa"? 

A cikin fagagen kula da fata da kuma maganin kwalliya, “sabuntawa” ra’ayi ne mai jan hankali. Lokacin da fata ta lalace ko tsufa, koyaushe muna fatan tayar da iyawarta ta gyara yanayinta. PDRN shine ainihin "maɓalli" wanda ƙungiyar kimiyya kwanan nan ta gano don kunna daidaitattun hanyoyin gyaran salula. A yau, za mu tona asirinta.

Asalin: Wahayi daga ikon sake farfadowa na teku

PDRN (Polydeoxyribonucleotide), wanda cikakken sunansa shine polydeoxyribonucleotide, ba samfurin da aka haɗa ta sinadarai ba ne, amma an samo shi daga ƙwayoyin haifuwa na salmon.

Masana kimiyya sun gano cewa salmon yana da ƙarfin sake farfadowa da nama da kuma iya gyarawa. Ta hanyar ƙarin bincike, sun fitar da wannan takamaiman DNA guntu-PDRN-daga maniyyi salmon. Wannan DNA ya yi kama da ainihin tsari ga DNA na duk dabbobi masu shayarwa (ciki har da mutane), yana nuna kyakkyawan yanayin rayuwa da ƙarancin ƙarancin ƙima na rigakafi, don haka yana ba da damar aminci da ingantaccen amfani a jikin ɗan adam.

Mahimmanci: Ba wai kawai "danyen abu ba ne," amma kuma "sigina."

Za mu iya fahimtar tsarin aikin PDRN daga ainihin mahanga guda biyu:

A matsayin "kayan gyarawa": PDRN ya ƙunshi deoxyribonucleotides da yawa (na asali raka'a na DNA). Lokacin da naman fata ya lalace kuma sel suna buƙatar rarraba da haɓaka don kammala gyara, waɗannan nucleotides da ke samuwa za a iya amfani da su kai tsaye ta hanyar sel azaman albarkatun ƙasa don haɗa sabon DNA, don haka haɓaka aikin gyaran.

A matsayin "siginar gyarawa": Wannan shine mafi mahimmanci kuma na musamman tsarin aikin PDRN. Ana iya gane PDRN musamman ta ƙwayoyin da ke kewaye da lalacewa ko nama na hypoxic da kuma ɗaure zuwa adenosine A2A masu karɓa a kan tantanin halitta, yana hana NF-kB da MAPK hanyoyin siginar da ROS ke kunna.  Wannan yana rage samar da cytokines pro-mai kumburi (IL-6, IL-1β, TNF-α, da dai sauransu) kuma yana inganta maganganun cytokines na anti-inflammatory (IL-10), don haka yana yin tasiri mai karfi.  Bugu da ƙari kuma, yana ƙarfafa ɓoyewar EGF (factor girma na epidermal), FGF (fibroblast growth factor), VEGF (nau'in haɓakar haɓakar ƙwayar cuta), da kuma angiopoietin, yana ba da PDRN kyakkyawan maganin kumburi da raunuka.

Babban aiki: Sarkar gyarawa daga micro zuwa matakin macro.

Dangane da hanyoyin da aka kwatanta a sama, PDRN yana aiwatar da jerin tasirin tasiri mai alaƙa a matakin fata:

Yana inganta angiogenesis: Yana ƙara samar da jini zuwa yankin da ya lalace, yana kawo ƙarin iskar oxygen da abubuwan gina jiki da kuma kawar da sharar gida.

Yana haɓaka haɓakar ƙwayoyin sel da ƙaura: Yana haɓaka aiki da adadin maɓallan gyaran sel kamar fibroblasts da keratinocytes.

Yana ƙarfafa haɗin gwiwar collagen da elastin: Ƙarfafa tsarin fata daga dermis, inganta layi mai kyau da kuma ƙara haɓaka.

Ƙarfin ƙwayar cuta mai ƙarfi: da kyau yana kwantar da halayen kumburi kamar ja, kumburi, zafi, da zafi ta hanyar daidaita abubuwan kumburi.

Gyaran nama da warkar da raunuka:  Haɗa duk abubuwan da ke sama, yana haɓaka aikin warkar da raunuka daban-daban na fata.

Ana kiran PDRN a matsayin "maɓalli don sabuntawa" saboda ba kawai gyarawa da ciyarwa ba, amma dai yana daidaita aikin tantanin halitta.  Dangane da haɓakar haɓakarsa mai girma, yana kunna yuwuwar farfadowar fata ta hanyar tasirin haɗin gwiwa da yawa. Wannan tsari na "farkawa iyawar gyaran jiki" shine ainihin abin da ake nema a fagen farfadowa, kuma shine abin da ya ba PDRN matsayin da ba zai iya maye gurbinsa ba a fagen lafiyar fata.