Bude PDRN: Shin wannan abin da ake nema na kula da fata shine gimmick na talla ko yana ba da sakamako da gaske? 

Kwanan nan, PDRN (polydeoxyribonucleotide) ya bayyana akai-akai a cikin kayan talla na aikin kula da fata da samfuran kayan kwalliya na likita.  Lakabi irin su "alurar DNA na salmon" da "gyara matakin DNA" sun sanya shi shahara cikin sauri, amma kuma sun haifar da cece-kuce: Shin wannan gimmick ne kawai na tallace-tallace da aka ƙirƙira ta babban birni, ko kuwa ingantaccen sinadari ne mai aiki tare da fa'idodi masu yawa? Wannan labarin zai bincika ainihin ƙimar PDRN daga hangen nesa na kimiyya, haɗa bincike na asibiti da bayanan aikace-aikacen masana'antu.

Babban ma'anar da dabaru na aiki na PDRN

PDRN wani polymer ne da aka kafa ta deoxyribonucleotides wanda aka haɗa ta hanyar haɗin phosphodiester, tare da nauyin kwayoyin halitta daga 50 zuwa 1500 kDa. Babban aikinsa na nazarin halittu ya samo asali ne daga tsarin adenosine. A halin yanzu, an fi fitar da albarkatun da aka yarda da su daga sel na haifuwa na salmon, amma kuma ana iya shirya su ta hanyar fermentation na microbial da dabarun ilimin halitta, kuma suna buƙatar gwaje-gwaje masu yawa don tsabtar acid nucleic da ayyukan nazarin halittu.

Tsarin aikinsa yana da tushe bayyanannen ilimin halitta, galibi ya kasu zuwa hanyoyi biyu:

1.Anti-mai kumburi tsarin hanya: A matsayin adenosine A2A agonist mai karɓa, zai iya daidaita daidaitattun IL-10 na anti-inflammatory factor kuma ya rushe abubuwan pro-inflammatory IL-6 da TNF-α, daidaita yanayin microenvironment na fata da kuma hana lalacewar danniya na oxidative;

2.Gyara da hanyar haɗin kai: A matsayin maƙasudin nucleotide don haɗin DNA na kwayar halitta, zai iya samar da kayan albarkatun kasa don sake gina kwayoyin halitta a cikin ƙwayoyin da suka lalace, haɓaka haɓakar epidermal da gyaran tsarin shinge. An tabbatar da wannan tsarin a cikin gwaje-gwajen ƙwayoyin in vitro da yawa da kuma nazarin asibiti.

Tabbatar da inganci: Ayyuka masu mahimmanci da bincike ke goyan bayan.

1.Barrier Repair and Anti-inflammatory Soothing: Clinically Proven Core Advantages

A fagen ilimin fata, PDRN yana da cikakkun bayanai masu goyan bayan tasirin sa wajen inganta lalacewar shinge da matsalolin fata masu kumburi. Nazarin asibiti ya nuna cewa shirye-shiryen da ke ɗauke da PDRN na iya inganta haɓakar alamun ja a cikin erythematotelangiectatic rosacea, tare da raguwar matsakaita na 32.7% a yankin erythema bayan makonni 4 na amfani; don raunukan hanyoyin kwaskwarima, zai iya rage lokacin warkar da epidermal da kashi 20% zuwa 30%, kuma yana rage jajayen aiki bayan aiki, kumburi, zafi, da zafi.

Bugu da ƙari, a cikin gwaje-gwajen aikace-aikacen da ake amfani da su don maganin dermatitis, PDRN ya rage yawan itching na fata da kuma ƙara yawan hydration na stratum corneum. Wannan ba jargon tallace-tallace ba ne, amma bayyanar kai tsaye na hanyoyin hana kumburi da gyaransa.

2.Whitening da Anti-tsufa: Tabbatar da Yin Aiki a Tushen Tushen

Gwaje-gwajen sel a cikin vitro sun tabbatar da cewa PDRN na iya hana ayyukan tyrosinase (ƙididdigar hanawa kusan 28%), rage ƙayyadaddun maganganun sunadarai masu sarrafa melanin kamar MITF, da rage samar da melanin; a lokaci guda, yana iya haɓaka ayyukan mitochondrial fibroblast, hana matrix metalloproteinase MMP-1, da haɓaka haɓakar collagen.

3.Kariyar Hoto: Gyara matakin DNA da aka yi niyya

Bayan hasken UV, ƙwayoyin fata suna fuskantar lalacewar DNA. PDRN na iya hanzarta kunna hanyar furotin p53 don fara hanyoyin gyaran DNA, rage sauye-sauyen halittar UV, da rage haɗarin hoto da lalata hoto. An tabbatar da wannan tasirin a cikin gwaje-gwajen samfurin salula da aka lalata kuma yana ɗaya daga cikin manyan fa'idodinsa waɗanda ke bambanta shi da kayan aikin antioxidant na yau da kullun.

Yankunan aikace-aikacen: daga mahimman buƙatun likita zuwa faɗaɗa aikace-aikace a cikin kulawar fata.

Aikace-aikacen PDRN bai fara da tallan fata ba; An fara gane darajarta a fannin likitanci, kuma daga baya a hankali ta faɗaɗa zuwa kayan kwalliyar likitanci da kula da fata. Ingancin a cikin yanayi daban-daban yana da fayyace iyakoki.

1. Filin Likita:

A farkon 2008, kamfanin Italiyanci Mastelli ya ƙaddamar da allurar magani na PDRN na farko, Placentex, wanda aka yi amfani da shi don gyara raunuka na yau da kullum (cututtukan ƙafar ciwon sukari, raunukan ƙonewa), lalacewar ƙwayar cuta, da lalacewar kashi. Bayanai na asibiti sun nuna cewa tasirin sa wajen warkar da raunuka masu wuyar warkewa na iya kaiwa kashi 76.5%, wanda hakan ya sa ya zama abin taimako da aka sani a asibiti don gyaran nama.

2. Filin Kyawun Jiki:

A cikin filin wasan kwaikwayo na likita, PDRN an fi sani da "salmon DNA" saboda kayan tushensa kuma ana amfani dashi sosai a cikin mesotherapy da gyaran gyare-gyaren microneedling. Hukumar Kula da Abinci da Magunguna ta Koriya (KFDA) ta haɗa da shi azaman mai yarda da sinadarai don dashen nama da jiyya a cikin 2008, yana haɓaka warkar da raunuka kaɗan a cikin kayan kwalliyar likita, haɓaka ja a cikin fata mai laushi da laushin fata. An tabbatar da tasirin sa ta hanyar amsawar asibiti daga cibiyoyin kayan kwalliyar likita.

3. Filin Kula da Fata na Aiki:

Tare da ci gaban fasaha, an sami nasarar shigar da PDRN cikin samfuran kula da fata. Don matsalolin fata da ke haifar da tsaftar kima, bawon sinadari, ko jiyya na laser, kamar raunin shingen fata, jajaye, da bushewa, PDRN na saman yana ba da siginonin gyarawa na yau da kullun idan aka kwatanta da na yau da kullun. Ba kai tsaye "magana" matsalar ba, amma yana haifar da mafi kyawun microenvironment don gyaran fata na fata ta hanyar rage kumburi da kuma inganta bambancin lafiya na keratinocytes.

Yawancin gyare-gyaren gyaran gyare-gyare masu yawa, magunguna, ko ampoules suna amfani da shi a matsayin wani abu mai mahimmanci, yana jaddada "ƙarfafawa da gyarawa" da kuma "anti-tsufa da ƙarfafawa".  Sau da yawa ana haɗa shi tare da abubuwan gyara shinge irin su ceramides da centella asiatica tsantsa don haɓaka ingancinsa, sannan kuma an haɗa shi da antioxidants (irin su SOD) don kare kariya daga lalacewar oxidative yayin gyaran fata.

Kammalawa

PDRN ba gimmick ba ne na talla; ta anti-mai kumburi da reparative effects, tare da DNA-matakin kariyar, ana goyan bayan m nazarin halittu hanyoyin da kuma asibiti bayanai.  Ana nuna ainihin ƙimar sa a aikace-aikace kama daga warkar da rauni na likita zuwa kula da aikin bayan kwaskwarima. Koyaya, a cikin kasuwar kula da fata mai aiki, wasu samfuran suna shiga ayyukan tallace-tallace na yaudara, kamar ƙari mai yawa da da'awar inganci.

Masu amfani ya kamata su fahimci cewa: PDRN-jinjin likita (injected/microneedled) yana ba da sakamako mai mahimmanci na gyarawa kuma ya dace da hanyoyin gyaran fuska ko lalacewar fata mai tsanani; Abubuwan kula da fata na PDRN na Topical sun dace da gyaran yau da kullun da kuma kula da fata mai laushi, da kuma don rigakafin tsufa da dalilai na fata a cikin fata. Mahimman fahimtar ƙimar sinadarai yana da mahimmanci don guje wa tarkon talla.