Cov kws tshaj lij pom zoo rau Daim Ntawv Thov Kev Kho Mob ntawm PDRN Acid Hauv Kev Kho Mob Dermatology 

Nyob rau hauv xyoo tas los no, polydeoxyribonucleic acid (PDRN) tau txais kev saib xyuas thiab siv dav hauv kev kho mob dermatology, tab sis tseem tsis muaj kev nkag siab txog kev sib koom ua ke ntawm cov qauv ntawm nws daim ntawv thov. Lub Laser Cosmetology Group ntawm Tuam Tshoj Medical Association lub ceg ntawm kev zoo nkauj thiab cov kws phais yas thiab lub Medical Cosmetology Group ntawm Tuam Tshoj Association ntawm Integrative Medicine koom ua ke tshaj tawm "Cov Kws Paub Pom Zoo ntawm Kev Siv Tshuaj Kho Mob ntawm Polydeoxyribonucleic Acid nyob rau hauv Dermatology," aiming muab cov kws kho mob nrog scientific thiab PD cov lus qhia nyob rau hauv lub hom phiaj ntawm daim ntawv thov.

Pharmacokinetics thiab Mechanism of Action ntawm PDRN

PDRN muaj nyob rau hauv plasma hauv daim ntawv dawb thiab tsis khi rau plasma apolipoproteins. Nws qhov kev faib tawm yog qhov zoo sib xws nrog cov ntaub so ntswg cov ntshav ntws. Cov tshuaj no tsis yog metabolized los ntawm daim siab; Nws yog tsuas yog degraded los ntawm non-specific plasma DNA nucleases los yog cell membrane nucleases los tsim cov active ingredient, mononucleotide. Thaum kawg, feem ntau ntawm nws tau tawm hauv cov zis (kwv yees li 65%), nrog me me tawm hauv cov quav.

PDRN degradation tsim nucleotides thiab nucleosides, muab cov ntaub ntawv raw rau kho DNA puas tsuaj thiab txhawb kev kho cov cell DNA puas thiab kev loj hlob sai.

Kev siv tshuaj kho mob ntawm PDRN hauv Dermatology

1. Kev Kho Mob

Kev tshawb fawb tam sim no tau pom tias PDRN koom nrog cov txheej txheem kho qhov txhab los ntawm ntau lub ces kaum, suav nrog inhibiting cov lus teb inflammatory ntau dhau, ua kom cov epidermal thiab dermal rov ua dua tshiab, txhawb nqa collagen deposition, thiab upregulating angiogenesis thiab lwm yam kev cai xws li VEGF. Hauv autologous daim tawv nqaij graft cov neeg mob, intramuscular, subcutaneous, los yog tshuaj pleev PDRN txhaj tshuaj ntawm lub qhov txhab tuaj yeem ua kom lub qhov txhab rov qab epithelialization thiab lub sijhawm kho. Tsis tas li ntawd, PDRN daim ntawv thov tom qab CO2 fractional laser kho tuaj yeem ua kom lub qhov txhab zoo; Yog li ntawd, PDRN tuaj yeem txiav txim siab tom qab kev kho laser ablative los txhawb kev kho qhov txhab thiab rov ua haujlwm ntawm daim tawv nqaij.

2. Melasma thiab Post-inflammatory Hyperpigmentation:

Feem ntau ua rau melasma thiab post-inflammatory hyperpigmentation feem ntau suav nrog kev ua kom tsis zoo ntawm melanocytes thiab cov lus teb tsis tu ncua. PDRN tuaj yeem tswj hwm kinase thiab protein kinase B txoj hauv kev los ntawm kev ua kom lub cev muaj zog ntxiv hauv melanocytes, txo qis cov qib ntawm dysplastic angiotensin ntsig txog kev hloov pauv, inhibiting kev qhia ntawm tyrosinase thiab melanin synthesis-related proteins, thiab txo cov ntsiab lus melanin ntawm melanocytes. Clinically, PDRN tuaj yeem txiav txim siab ua ke nrog rau lwm txoj hauv kev los kho cov kab mob refractory pigmentary xws li melasma lossis post-inflammatory hyperpigmentation. 3. Kev laus ntawm daim tawv nqaij:

PDRN activates adenosine A2A receptors los yog txoj kev cawm seej, upregulates cyclic adenosine monophosphate (cAMP) concentration, inhibits MMPs thiab elastase secretion, remodels extracellular matrix, txo wrinkles, restores tawv elasticity, thiab txhim kho daim tawv nqaij kev ntxhib los mos. Tsis tas li ntawd, ntau txoj kev tshawb fawb tau pom tias PDRN tuaj yeem txo qis cov qib ntawm ntau yam pro-inflammatory yam xws li IL-6, IL-1β, TNF-α, thiab IL-12, thiab txhawb kev tso tawm ntawm cov kab mob inflammatory xws li IL-10. Qhov no qhia tau hais tias PDRN ib txhij tuaj yeem ncua qhov tshwm sim thiab kev loj hlob ntawm daim tawv nqaij photoaging los ntawm inhibiting SASP secretion, txhim kho daim tawv nqaij elasticity, roughness, thiab loj pores, thiab txo transepidermal dej poob, yog li daws teeb meem ntawm daim tawv nqaij laus.

4. Scarring:

Hauv SD nas incision kho tus qauv, PDRN tau pom los txo cov cell infiltration hauv caws pliav thiab inhibiting caws pliav ntau dhau los ntawm inhibiting HMGB-1 qhia. Cov kev tshawb fawb soj ntsuam thoob ntiaj teb tau pom tias kev siv PDRN thaum ntxov tom qab thyroidectomy tuaj yeem txhim kho qhov zoo nkauj, xim, thiab qhov loj ntawm hypertrophic nti, nrog kev nyab xeeb zoo thiab tsis muaj kev phiv tshuaj. Yog li ntawd, kev cuam tshuam ntxov nrog PDRN tuaj yeem txiav txim siab rau qhov txhab ntawm qhov pheej hmoo ntawm caws pliav. Tam sim no, tsis muaj kev tshawb fawb txog kev ua tau zoo ntawm PDRN hauv keloids.

5. Androgenetic Alopecia:

Cov neeg mob uas muaj androgenetic alopecia pom cov tawv taub hau hloov xws li txo qis thiab cov hlab ntsha me me. PDRN tuaj yeem tswj hwm txoj hauv kev Wnt signaling, txhawb cov plaub hau follicle proliferation, thiab upregulate VEGF thiab lwm yam vasoactive agents, yog li txhim kho androgenetic alopecia. Cov kev tshawb fawb yav tom ntej tau pom tias rau cov neeg mob uas muaj androgenetic alopecia uas tsis teb rau cov kev kho tshuaj ib txwm siv, kev siv PDRN ua ke nrog PRP lossis 1927nm thulium fractional laser kho tej zaum yuav yog ib qho kev xaiv. Txawm li cas los xij, cov qauv loj dua tseem xav tau los ntsuas kev nyab xeeb.

6. Lwm yam kab mob ntawm daim tawv nqaij:

Cov neeg mob uas muaj androgenetic alopecia pom cov tawv taub hau hloov xws li txo qis thiab cov hlab ntsha me me. PDRN tuaj yeem tswj hwm txoj hauv kev Wnt signaling, txhawb cov plaub hau follicle proliferation, thiab upregulate VEGF thiab lwm yam vasoactive agents, yog li txhim kho androgenetic alopecia. Cov kev tshawb fawb yav tom ntej tam sim no tau tawm tswv yim tias PDRN ua ke nrog PRP lossis 1927nm thulium fractional laser kho tej zaum yuav yog ib qho kev xaiv rau cov neeg mob uas muaj androgenetic alopecia uas tsis teb rau cov kev kho mob ib txwm siv. Txawm li cas los xij, cov qauv loj dua tseem xav tau los ntsuas nws txoj kev nyab xeeb.

Pom zoo siv

Kev siv PDRN sib txawv heev ntawm cov kab mob sib txawv, thiab cov txheej txheem kev sib koom ua ke tseem tsis muaj.

Tam sim no, cov ntaub ntawv hauv tsev thiab thoob ntiaj teb tau tshaj tawm PDRN cov txheej txheem kev tswj hwm suav nrog kev siv tshuaj pleev ib ce, kev xa tawm intradermal, kev txhaj tshuaj intradermal, txhaj tshuaj subcutaneous, thiab txhaj tshuaj intramuscular. Kev siv ntau zaus ntawm ib hnub mus rau ib zaug hauv ib lub lim tiam, thiab kev siv sijhawm ntau los ntawm ob peb hnub mus rau ob peb lub lis piam. Txawm li cas los xij, cov kev siv tshwj xeeb yuav tsum tau ua raws li cov khoom lag luam (tshuaj lossis khoom siv kho mob) kev faib tawm.

Kev nyab xeeb thiab ceev faj

1. PDRN muaj DNA purity> 95% thiab tsis muaj pharmacologically active proteins los yog peptides, yog li nws cov immunogenicity yog tsawg.
2. Ntau qhov kev tshawb fawb soj ntsuam kuj tau lees paub tias PDRN muaj kev nyab xeeb zoo thiab kev zam txim tsis hais txog txoj kev tswj hwm. Tsis muaj kev cuam tshuam loj heev los yog muaj kev cuam tshuam loj heev tau raug pom tom qab siv tshuaj pleev ib ce, txawm hais tias qee zaus muaj kev cuam tshuam me me xws li tawv nqaij liab, khaus, thiab stinging tuaj yeem tshwm sim. Cov tsos mob no feem ntau yuav sai sai tom qab txiav cov tshuaj los yog nrog kev kho mob.
3. Muaj qhov ua rau muaj qhov tshwm sim tsis zoo xws li lub cev txawv teb chaws granulomas thiab cov kab mob tshwj xeeb thaum PDRN raug txhaj tshuaj. Yog li, ceev faj yuav tsum tau siv thaum siv cov tshuaj no intradermally lossis subcutaneously.
4. PDRN yog contraindicated nyob rau hauv cev xeeb tub thiab lactating poj niam, cov neeg uas muaj kab mob qhov txhab, thiab cov tsis haum rau PDRN.

Summary thiab Outlook

1. Hauv Suav teb, PDRN feem ntau yog siv tshuaj pleev ib ce thiab los ntawm microneedling mesotherapy. Muab PDRN cov tshuaj tiv thaiv kab mob thiab cov ntaub so ntswg kho-txhim kho lub peev xwm, kev tshawb fawb yav tom ntej tuaj yeem tshawb nrhiav nws lub peev xwm rau kev siv tshiab.
2. Tsis tas li ntawd, cov tswv yim kev tswj hwm rau PDRN hauv kev kho mob ntawm ntau yam teeb meem ntawm daim tawv nqaij, suav nrog kev txiav txim siab txoj hauv kev zoo tshaj plaws ntawm kev tswj hwm, zaus, thiab concentration, nrog rau nws cov txiaj ntsig zoo nrog rau lwm yam kev kho mob, xav tau kev tshawb nrhiav ntxiv.