Recombinant human superoxide dismutase (rhSOD): Ib qho tshiab ntawm kev ua haujlwm ntawm antioxidants txhawb nqa los ntawm biotechnology. 

Peb lub cev ib txwm tsim superoxide dismutase (SOD), tab sis ntau yam kev cov nyom ntawm lub neej niaj hnub no dhau los ua nws lub peev xwm. Kev ntxiv nrog SOD tsis yog tsuas yog ib qho txiaj ntsig ntxiv, tab sis yog qhov tsim nyog ntxiv rau lub cev. Kev xaiv ntawm SOD ntxiv, txawm li cas los xij, txiav txim siab qhov ua tau zoo thiab kev nyab xeeb ntawm qhov kev txhawb nqa no.

Ua ntej sib tham txog "dab tsi ntxiv," peb yuav tsum xub to taub "vim li cas peb thiaj li yuav tsum tau ntxiv." Qhov no tsis yog tsuas yog hais txog kev zoo nkauj, tab sis kuj hais txog lub hauv paus ntsiab lus ntawm kev noj qab haus huv.

Vim li cas thiaj yuav tsum tau ntxiv nrog superoxide dismutase (SOD)?

Tib neeg lub cev yeej muaj nws tus kheej "SOD cov kab ntau lawm," tab sis nrog lub hnub nyoog thiab kev hloov hauv kev ua neej, "supply-demand balance" ntawm SOD maj mam tawg, ua rau ntau dhau ntawm cov dawb radicals, ua rau lub cev ua haujlwm thiab ua kom cov txheej txheem laus.

1.Aging:  Lub cev tus kheej SOD "tso tawm," thiab nws lub peev xwm scavenging tau txwv.

Hnub nyoog 25 yog qhov tseem ceeb: Ua ntej hnub nyoog 25 xyoos, lub cev tus nqi ntawm SOD synthesis tuaj yeem yooj yim "kuj" nrog tus nqi ntawm cov dawb radical ntau lawm; Txawm li cas los xij, tom qab hnub nyoog 25 xyoos, SOD synthesis txo qis ntawm tus nqi ntawm 1% -2% ib xyoos. Thaum muaj hnub nyoog 40 xyoo, lub cev ua haujlwm SOD tsuas yog 50% ntawm nws qhov siab tshaj plaws, thiab tom qab hnub nyoog 60 xyoo, nws tsawg dua 30%.

Lub caij no, kev tsim cov dawb radicals tsis txo qis - cell metabolism thiab ua pa tsis tu ncua tsim superoxide anion dawb radicals. Qhov no ua rau tsis txaus SOD, thiab cov dawb radicals ntau dhau pib tua cov hlwb: ua rau daim tawv nqaij collagen (ua rau wrinkles), ua rau vascular endothelium (ua kom vascular aging), thiab oxidizing daim siab hlwb (ua rau metabolic hnyav). Qhov no yog ib qho ntawm cov laj thawj tseem ceeb rau "kev laus."

2.Lub neej niaj hnub: Tshaj dawb radicals, tsis txaus Endogenous SOD

Dhau li ntawm hnub nyoog, kev ua neej nyob txhua hnub tseem ua kom cov dawb radicals:

UV raug: tshav raug rau ib teev ib hnub twg ua rau cov dawb radicals tsim los ntawm daim tawv nqaij los ntawm peb zaug, deb tshaj lub cev tus kheej SOD (superoxide dismutase) clearing peev;

Hmo ntuj thiab kev ntxhov siab: Thaum pw tsaug zog lossis tsis muaj kev ntxhov siab, lub cev secretes "cov tshuaj hormones kev nyuaj siab," txhawb kev tsim cov dawb radicals ntau;

Kev noj zaub mov tsis zoo: Cov piam thaj ntau, rog rog, thiab cov khoom noj kib ua rau cov khoom siv glycation kawg thaum lub sij hawm metabolism, nrog rau ntau cov dawb radicals;

Ib puag ncig muaj kuab paug: Cov khoom tsis zoo hauv smog, lub tsheb tso tsheb, thiab cov pa luam yeeb thib ob, tom qab nkag mus rau tib neeg lub cev, ua rau "oxidative stress," uas ua rau muaj kev loj hlob ntawm cov dawb radicals;

Kev cuam tshuam ntawm Kab Mob: Cov kab mob tshwm sim los ntawm kev mob thiab cov txheej txheem ntawm cov tshuaj metabolism hauv ob qho tib si exacerbate oxidative kev nyuaj siab hauv lub cev, ua ib qho tseem ceeb tsav tsheb ntawm qhov txawv txav ntawm cov dawb radicals.

3.Lub cev tus kheej SOD muaj "tsim muaj peev xwm" thiab tsis tuaj yeem tiv nrog "kev tawm tsam siab."

Txawm nyob rau hauv cov tub ntxhais hluas uas muaj kev noj qab nyob zoo lub neej, lub cev tus kheej SOD muaj nws cov kev txwv: nws yog feem ntau yog concentrated nyob rau hauv lub hlwb thiab muab tsis txaus kev pab cuam tiv thaiv dawb radicals nyob rau hauv cov ntshav thiab rau ntawm daim tawv nqaij; Tsis tas li ntawd, nws cov dej num tsis siab txaus kom tshem tawm cov dawb radicals thaum lub sij hawm "sib xyaws tawg" (xws li tom qab tshav ntuj los yog kev tawm dag zog hnyav).

Qhov no yog qhov uas ntxiv nrog SOD ua qhov tsim nyog - nws zoo li ntxiv "cov tshuaj ntxuav tau zoo" rau lub cev kom pab tshem tawm cov dawb radicals sai sai thiab tiv thaiv kev puas tsuaj ntawm tes.