Nkwenye ndị ọkachamara na ngwa ụlọ ọgwụ nke PDRN Acid na Dermatology 

N'ime afọ ndị na-adịbeghị anya, polydeoxyribonucleic acid (PDRN) enwetala nlebara anya na itinye n'ọrụ na ngalaba nke dermatology, mana a ka nwere enweghị nghọta dị n'otu gbasara nhazi nke ngwa ya. The Laser Cosmetology Group of the Chinese Medical Association's Branch of Aesthetic and Plastic Surgeons na Medical Cosmetology Group nke Chinese Association of Integrative Medicine jikọrọ aka nyere "Ọkachamara Nkwenye na Clinical Ngwa nke Polydeoxyribonucleic Acid na Dermatology," aiming inye clinicians na ndụmọdụ sayensị na ebumnobi ndụmọdụ na-eduzi ha na ezi uche na omume nke PDRN.

Pharmacokinetics na Mechanism nke Action nke PDRN

PDRN dị na plasma n'ụdị efu na anaghị ejikọta na apolipoproteins plasma. A na-ejikọta nkesa ya nke ọma na mgbaba ọbara anụ ahụ. Nke a ọgwụ na-adịghị metabolized site imeju; A na-eweda ya nke ukwuu site na DNA nucleases plasma na-abụghị nke akọwapụtara ma ọ bụ nucleases membrane cell iji mepụta ihe na-arụ ọrụ, mononucleotide. N'ikpeazụ, ọtụtụ n'ime ya na-esi na mmamịrị (ihe dị ka 65%), na-ewepụkwa ntakịrị n'ime nsị.

Nbibi nke PDRN na-emepụta nucleotides na nucleosides, na-enye akụrụngwa maka nrụzi DNA mebiri emebi ma na-akwalite ngwa ngwa nrụzi DNA cell mebiri emebi na mmụba cell.

Ngwa Clinical nke PDRN na Dermatology

1. Ọgwụgwọ ọnya

Nnyocha a na-eme ugbu a achọpụtala na PDRN na-ekere òkè na usoro ọgwụgwọ ọnya site n'ọtụtụ akụkụ, gụnyere igbochi mmeghachi omume mkpali dị ukwuu, na-eme ka epidermal na mmeghari ohuru nke dermal, na-akwalite ntinye nke collagen, na ịkwalite angiogenesis na ihe ndị ọzọ na-achịkwa dịka VEGF. N'ime ndị na-ahụ anya akpụkpọ anụ na-akpa aka, intramuscular, subcutaneous, ma ọ bụ n'elu PDRN injections na saịtị ọnya nwere ike ime ka ọnya na-eweghachite epithelialization na oge ọgwụgwọ. Ọzọkwa, ngwa PDRN mgbe CO2 fractional laser ọgwụgwọ nwere ike mee ngwangwa ọgwụgwọ ọnya; Ya mere, enwere ike ịtụle PDRN mgbe ọgwụgwọ laser ablative ga-akwalite ọgwụgwọ ọnya na iweghachi ọrụ mgbochi akpụkpọ ahụ.

2. Melasma na post-inflammatory hyperpigmentation:

Ihe na-akpatakarị melasma na post-inflammatory hyperpigmentation bụ isi gụnyere ịgbalite melanocytes na-adịghị mma yana nzaghachi mkpali na-adịgide adịgide. PDRN nwere ike ịhazi kinase na protein kinase B ụzọ site n'ịgbalite akara ngosi extracellular na melanocytes, na-ebelata ọkwa nke ihe odide ederede nke angiotensin metụtara dysplastic, na-egbochi nkwupụta nke tyrosinase na protein protein metụtara melanin, na ibelata ọdịnaya melanin nke melanocytes. N'ụlọ ọgwụ, enwere ike ịtụle PDRN yana ụzọ ndị ọzọ iji gwọọ ọrịa ndị na-agbapụta agba agba dị ka melasma ma ọ bụ hyperpigmentation post-inflammatory. 3. Ịka nká akpụkpọ:

PDRN na-arụ ọrụ ndị na-anabata adenosine A2A ma ọ bụ ụzọ mgbapụta, na-akwalite mkpokọta adenosine monophosphate (cAMP) cyclic, na-egbochi MMPs na elastase secretion, na-emegharị matrix extracellular, na-ebelata wrinkles, na-eweghachi ngbanwe akpụkpọ ahụ, na-eme ka ọdịdị akpụkpọ ahụ dịkwuo mma. Ọzọkwa, ọtụtụ nchọpụta achọpụtala na PDRN nwere ike imebi ọkwa nke ihe dị iche iche pro-inflammatory dị ka IL-6, IL-1β, TNF-α, na IL-12, ma na-edozi ihe nzuzo nke ihe ndị na-egbuke egbuke dị ka IL-10. Nke a na-egosi na PDRN nwere ike n'otu oge na-egbu oge ihe omume na mmepe nke fotoaging akpụkpọ ahụ site na igbochi SASP nzuzo, na-eme ka akpụkpọ ahụ dịkwuo mma, adịghị ike, na nnukwu pores, na ibelata mmiri transepidermal, si otú a na-edozi nsogbu ịka nká akpụkpọ ahụ.

4. Anya:

N'ime usoro ọgwụgwọ oke oke SD, achọpụtara na PDRN na-ebelata ntinye mkpụrụ ndụ mkpali n'anụ ahụ ma gbochie mgbasa nke ọnya dị ukwuu site na igbochi okwu HMGB-1. Ọmụmụ ụlọ ọgwụ mba ụwa achọpụtala na iji PDRN n'oge mgbe thyroidectomy gasịrị nwere ike imeziwanye udidi, agba, na oke nke hypertrophic scars, na-enwe ezigbo nchekwa na enweghị mmeghachi omume ọjọọ. Ya mere, a pụrụ ịtụle ntinye aka na PDRN n'oge maka ọnya dị n'ihe ize ndụ nke ịcha. Ugbu a, ọnweghị ọmụmụ banyere ịdị irè nke PDRN na keloids.

5. Androgenic alopecia:

Ndị ọrịa nwere alopecia androgenetic na-egosipụta mgbanwe isi isi dị ka mbelata na obere arịa ọbara. PDRN nwere ike ịhazi ụzọ mgbaama Wnt, kwalite mmụba ntutu isi, ma kwalite VEGF na ihe ndị ọzọ na-akpata vasoactive, si otú ahụ na-emeziwanye androgenetic alopecia. Nnyocha ndị a na-atụ anya achọpụtala na maka ndị ọrịa nwere alopecia androgenetic na-adịghị anabata usoro ọgwụgwọ ọgwụ, iji PDRN jikọtara PRP ma ọ bụ 1927nm thulium fractional laser treatment nwere ike ịbụ nhọrọ. Agbanyeghị, a ka chọrọ nha nlele ka ukwuu iji chọpụta nchekwa.

6. Ọrịa akpụkpọ anụ ndị ọzọ:

Ndị ọrịa nwere alopecia androgenetic na-egosipụta mgbanwe isi isi dị ka mbelata na obere arịa ọbara. PDRN nwere ike ịhazi ụzọ mgbaama Wnt, kwalite mmụba ntutu isi, ma kwalite VEGF na ihe ndị ọzọ na-akpata vasoactive, si otú ahụ na-emeziwanye androgenetic alopecia. Ọmụmụ ihe dị ugbu a na-atụ aro na PDRN jikọtara ya na PRP ma ọ bụ 1927nm thulium fractional laser treatment nwere ike ịbụ nhọrọ nwere ike maka ndị ọrịa nwere alopecia androgenetic na-adịghị anabata ọgwụgwọ ọgwụ. Otú ọ dị, a ka na-achọ ụdị nlele buru ibu iji chọpụta nchekwa ya.

akwadoro ojiji

Ojiji nke PDRN dịgasị iche iche n'ofe ọrịa dị iche iche, na usoro ngwa ngwa jikọtara ọnụ ka na-efu.

Ugbu a, akwụkwọ akụkọ ụlọ na mba ụwa na-akọ usoro nchịkwa PDRN gụnyere ngwa n'elu, nnyefe intradermal, injection intradermal, injection subcutaneous, na intramuscular injection. Ugboro onunu ogwu na-adị site na otu ugboro kwa ụbọchị ruo otu ugboro kwa izu, na oge doses sitere na ọtụtụ ụbọchị ruo ọtụtụ izu. Agbanyeghị, a ga-agbasorịrị usoro ojiji akọwapụtara nke ọma dabere na nhazi ngwaahịa (ọgwụ ma ọ bụ ngwaọrụ ahụike).

Nchekwa na ịkpachapụ anya

1. PDRN nwere ịdị ọcha DNA> 95% na enweghị protein ma ọ bụ peptides na-arụ ọrụ ọgwụ, yabụ immunogenicity ya dị ala.
2. Ọtụtụ ọmụmụ ụlọ ọgwụ ekwenyekwala na PDRN nwere ezigbo nchekwa na nnabata n'agbanyeghị ụzọ nchịkwa. Ọnweghị mmeghachi omume nsi dị ukwuu ma ọ bụ mmeghachi omume ọjọọ achọpụtala mgbe etinyere ya n'elu, ọ bụ ezie na mmeghachi omume ọjọọ dị nro dị ka acha ọbara ọbara, itching, na nsị nwere ike ime. Mgbaàmà ndị a na-ebelata ngwa ngwa ka ịkwụsị ọgwụ ahụ ma ọ bụ na ọgwụgwọ mgbaàmà.
3. Enwere ike ime ihe ọjọọ dị ka granuloma anụ ahụ si mba ọzọ na ọrịa ndị a kapịrị ọnụ mgbe a na-enye PDRN site na ntụtụ. Ya mere, ekwesịrị ịkpachara anya mgbe ị na-eji ọgwụ a intradermally ma ọ bụ subcutaneously.
4. PDRN bụ contraindicated n'ime ụmụ nwanyị dị ime na ndị na-enye nwa ara, ndị nwere ọnya ọrịa, na ndị nwere ihe nfụkasị ahụ na PDRN.

Nchịkọta na Outlook

1. Na China, a na-etinye PDRN n'isi na site na microneedling mesotherapy. Nyere mmetụta mgbochi mkpali nke PDRN na ike na-akwalite anụ ahụ, nyocha n'ọdịnihu nwere ike ịchọpụta ikike ya maka ngwa ọhụrụ.
2. Ọzọkwa, usoro nchịkwa maka PDRN na ọgwụgwọ nke nsogbu akpụkpọ anụ dị iche iche, gụnyere ikpebi ụzọ kachasị mma nke nchịkwa, ugboro ole na ntinye uche, yana mmetụta ya na usoro ọgwụgwọ ndị ọzọ, chọrọ nyocha ọzọ.