Recombinant human superoxide dismutase (rhSOD): Kupambana kwatsopano mu gawo la ma antioxidants opatsidwa mphamvu ndi biotechnology. 

Matupi athu mwachibadwa amapanga superoxide dismutase (SOD), koma zovuta zambiri za moyo wamakono zimagonjetsa mphamvu zake. Kuonjezera ndi SOD sikungowonjezera phindu, koma kulimbikitsa thupi. Kusankhidwa kwa chowonjezera cha SOD, komabe, kumatsimikizira kuchita bwino ndi chitetezo cha kulimbitsa uku.

Tisanakambirane "chomwe tingawonjezere," choyamba tiyenera kumvetsetsa "chifukwa chiyani tiyenera kuwonjezera." Izi sizokhudza kukongola kokha, komanso za mfundo zofunika za thanzi.

Chifukwa chiyani kuli kofunikira kuwonjezera ndi superoxide dismutase (SOD)?

Thupi la munthu limakhala ndi "mzere wopanga ma SOD," koma ndi zaka komanso kusintha kwa moyo, "kuchuluka kwa zinthu zofunika" kwa SOD kumawonongeka pang'onopang'ono, zomwe zimapangitsa kuti ma radicals aulere achuluke, kuwononga ntchito za thupi ndikufulumizitsa ukalamba.

1.Kukalamba:  Kapangidwe kake ka SOD m'thupi kumachepa, ndipo mphamvu yake yowononga imakhala yochepa.

Zaka 25 ndizofunikira kwambiri: Asanakwanitse zaka 25, mlingo wa thupi la SOD synthesis mosavuta "kupitirira" ndi mlingo wa kupanga kwaulere; Komabe, pambuyo pa zaka 25, SOD kaphatikizidwe amachepetsa pa mlingo wa 1% -2% pachaka. Pofika zaka 40, zochita za thupi la SOD zimangokhala 50% ya msinkhu wake wapamwamba, ndipo pambuyo pa zaka 60, zimakhala zosakwana 30%.

Pakadali pano, kupanga ma free radicals sikuchepa - cell metabolism ndi kupuma kumatulutsa ma superoxide anion free radicals. Izi zimabweretsa SOD yosakwanira, ndipo ma radicals owonjezera aulere amayamba kuukira maselo: kuwononga collagen ya khungu (kuyambitsa makwinya), kuwononga endothelium yamtima (kukulitsa ukalamba wa mtima), ndi ma cell oxidizing a chiwindi (kuchulukitsa kagayidwe kachakudya). Ichi ndi chimodzi mwa zifukwa zazikulu za "kukalamba."

2.Moyo Wamakono: Zowonjezereka Zopanda Ma radicals, Zosakwanira Endogenous SOD

Kupatula zaka, zizolowezi zatsiku ndi tsiku zimathandiziranso kupanga ma free radicals:

Kuwonekera kwa UV: Kuwonekera kwa dzuwa kwa ola limodzi patsiku kumawonjezera ma free radicals opangidwa ndi khungu katatu, kupitilira mphamvu yakuchotsa SOD (superoxide dismutase) ya thupi;

Madzulo ndi kupsinjika maganizo: Pamene tulo tasowa kapena kupsinjika maganizo, thupi limatulutsa "mahomoni opsinjika maganizo," zomwe zimachititsa kuti pakhale ma radicals ambiri aulere;

Zakudya zopanda pake: Zakudya zokhala ndi shuga wambiri, mafuta ambiri, komanso zokazinga zimatulutsa zinthu zomaliza za glycation panthawi ya metabolism, zomwe zimatsagana ndi kuchuluka kwa ma free radicals;

Kuwonongeka kwa chilengedwe: Zinthu zovulaza mu utsi, utsi wa galimoto, ndi utsi wa fodya, zikamalowa m'thupi la munthu, zimayambitsa "kupanikizika kwa okosijeni," zomwe zimapangitsa kuti ma free radicals achuluke;

Kukhudza kwa matenda: Matenda obwera chifukwa cha matenda komanso kagayidwe kazakudya zimawonjezera kupsinjika kwa okosijeni m'thupi, zomwe zimapangitsa kuti ma free radicals achuluke.

3.SOD ya thupi lomwe lili ndi "mphamvu zochepa" ndipo silingathe kulimbana ndi "kuukira kwakukulu."

Ngakhale mwa achinyamata omwe ali ndi moyo wathanzi, SOD ya thupi ili ndi malire ake: imakhala yokhazikika kwambiri mkati mwa maselo ndipo imapereka chitetezo chokwanira motsutsana ndi zowonongeka zaufulu m'magazi ndi pakhungu; Komanso, ntchito yake sipamwamba mokwanira kuti athetse bwino ma radicals aulere panthawi ya "kuphulika kwakukulu" (monga pambuyo pa dzuwa kapena kuchita masewera olimbitsa thupi).

Apa ndipamene kuwonjezera ndi SOD kumakhala kofunikira - kuli ngati kuwonjezera "zoyeretsa bwino kwambiri" m'thupi kuti zithandizire kuchotsa mwachangu ma radicals aulere komanso kupewa kuwonongeka kwa ma cell mosalekeza.