Kuvumbulutsa PDRN: Kodi chinthu chomwe chimafunidwa kwambiri ndi skincare ndi gimmick yotsatsa kapena chimabweretsadi zotsatira? 

Posachedwapa, PDRN (polydeoxyribonucleotide) yawonekera pafupipafupi muzinthu zotsatsira za skincare ndi zokometsera zamankhwala.  Zolemba monga "jakisoni wa DNA wa salimoni" ndi "kukonza mlingo wa DNA" zapangitsa kuti zikhale zodziwika bwino, komanso zadzetsa mikangano: Kodi uku kungokhala malingaliro otsatsa opangidwa ndi capital, kapena ndi chinthu chogwira ntchito chomwe chili ndi phindu lalikulu? Nkhaniyi isanthula phindu lenileni la PDRN kuchokera pamalingaliro asayansi, kuphatikiza kafukufuku wazachipatala ndi deta yogwiritsira ntchito makampani.

Tanthauzo lalikulu ndi malingaliro ogwirira ntchito a PDRN

PDRN ndi polima yopangidwa ndi deoxyribonucleotides yolumikizidwa ndi ma phosphodiester bond, okhala ndi molekyulu yolemera kuyambira 50 mpaka 1500 kDa. Ntchito yake yayikulu yachilengedwe imachokera ku kapangidwe ka adenosine. Pakalipano, zopangira zovomerezeka zimachotsedwa makamaka ku maselo obereketsa a salimoni, komanso zimatha kukonzedwa kudzera mu njira zoyatsira tizilombo komanso njira zopangira biology, ndipo zimafuna kuyesedwa kangapo kwa nucleic acid chiyero ndi zochitika zamoyo.

Kachitidwe kake kamakhala ndi maziko omveka bwino achilengedwe, omwe amagawidwa m'njira ziwiri:

1.Anti-inflammatory regulatory pathway: Monga adenosine A2A receptor agonist, ikhoza kuwongolera bwino chinthu chotsutsa-kutupa IL-10 ndi kuchepetsa zomwe zimayambitsa kutupa kwa IL-6 ndi TNF-α, kugwirizanitsa khungu la microenvironment ndi kulepheretsa kuwonongeka kwa oxidative kupsinjika maganizo;

2.Kukonza ndi njira yophatikizira: Monga nucleotide precursor for cell DNA synthesis, ikhoza kupereka zipangizo zopangira ma genetic m'maselo owonongeka, kufulumizitsa kufalikira kwa epidermal ndi kukonza zotchinga. Njira iyi yatsimikiziridwa muzoyeserera zingapo zama cell mu vitro komanso maphunziro azachipatala.

Kutsimikizira kugwira ntchito: Ntchito zazikulu zothandizidwa ndi kafukufuku.

1.Barrier Repair and Anti-inflammatory Soothing: Ubwino Wotsimikiziridwa ndi Zachipatala

Pankhani ya dermatology, PDRN ili ndi deta yomveka bwino yomwe imathandizira kuti ikhale yothandiza pakuwongolera kuwonongeka kwa zotchinga ndi zovuta zotupa pakhungu. Kafukufuku wachipatala amasonyeza kuti mankhwala omwe ali ndi PDRN amatha kusintha kwambiri zizindikiro za redness mu erythematotelangiectatic rosacea, ndi kuchepetsa pafupifupi 32,7% m'dera la erythema pambuyo pa masabata a 4 a ntchito; kwa mabala a post-cosmetic process, amatha kufupikitsa nthawi yamachiritso a epidermal ndi 20% mpaka 30%, ndikuchepetsa kufiira kwapambuyo, kutupa, kutentha, ndi ululu.

Kuphatikiza apo, pakuyesa kwapamutu kwa atopic dermatitis, PDRN idachepetsa kuyabwa kwapakhungu ndikuwonjezera stratum corneum hydration. Izi sizomwe zimagulitsa malonda, koma chiwonetsero chachindunji cha njira zake zotsutsana ndi kutupa ndi kukonza.

2. Whitening ndi Anti-kukalamba: Zatsimikiziridwa Kuti Zimagwira Ntchito pa Muzu

Kuyesera kwa maselo a m'mimba kwatsimikizira kuti PDRN ikhoza kuletsa ntchito ya tyrosinase (kuletsa mlingo wa pafupifupi 28%), kuchepetsa kuwonetsetsa kwa mapuloteni oyendetsa melanin monga MITF, ndi kuchepetsa kupanga melanin; nthawi yomweyo, imatha kupititsa patsogolo ntchito ya fibroblast mitochondrial, kuletsa matrix metalloproteinase MMP-1, ndikulimbikitsa kaphatikizidwe ka collagen.

3.Chitetezo cha Photodamage: Kukonzekera kwa mlingo wa DNA

Pambuyo pa kuwala kwa UV, maselo a khungu amawonongeka ndi DNA. PDRN imatha kuyambitsa njira yama protein ya p53 mwachangu kuti ayambitse njira zokonzetsera DNA, kuchepetsa kusintha kwa ma jini opangidwa ndi UV, ndikuchepetsa chiwopsezo cha kujambula ndi kujambula. Izi zatsimikiziridwa mu kuyesa kwa ma cell a photodamaged ndipo ndi chimodzi mwazabwino zake zomwe zimasiyanitsa ndi zosakaniza wamba za antioxidant.

Malo ogwiritsira ntchito: kuchokera ku zofunikira zachipatala kupita ku ntchito zowonjezera pa skincare.

Kugwiritsa ntchito PDRN sikunayambe ndi malonda a skincare; mtengo wake udazindikirika koyamba muzachipatala, ndipo kenako pang'onopang'ono udakulitsidwa ku zokometsera zamankhwala ndi skincare. Kuchita bwino muzochitika zosiyanasiyana kumakhala ndi malire omveka.

1.Medical Field:

Kumayambiriro kwa 2008, kampani ya ku Italy yotchedwa Mastelli inayambitsa jekeseni yoyamba ya mankhwala ya PDRN, Placentex, yomwe imagwiritsidwa ntchito pokonza mabala aakulu (zilonda zam'mimba za matenda a shuga, mabala oyaka moto), kuwonongeka kwa cornea, ndi kuwonongeka kwa mafupa. Deta yachipatala imasonyeza kuti mlingo wake wothandiza pochiritsa mabala ovuta kuchiritsa amatha kufika 76.5%, ndikupangitsa kuti ikhale chigawo chodziwika bwino chothandizira kukonza minofu.

2.Medical Aesthetics Field:

M'gawo lazachipatala, PDRN imadziwika kuti "salmon DNA" chifukwa cha gwero lake ndipo imagwiritsidwa ntchito kwambiri mu mesotherapy ndi post-microneedling kukonza. Korea Food and Drug Administration (KFDA) idaphatikizirapo ngati chothandizira pakuyika minofu ndikuchiza mabala mu 2008, kufulumizitsa kuchira kwa mabala osawoneka bwino muzokongoletsa zamankhwala, kuwongolera kufiira pakhungu lovuta komanso mawonekedwe akhungu. Zotsatira zake zatsimikiziridwa ndi ndemanga zachipatala kuchokera ku mabungwe a aesthetics azachipatala.

3.Functional Skincare Field:

Ndi kupita patsogolo kwaukadaulo, PDRN idaphatikizidwa bwino muzinthu zosamalira khungu. Pazovuta zapakhungu zomwe zimayambitsidwa ndi kuyeretsa kwambiri, ma peels a mankhwala, kapena chithandizo cha post-laser, monga chotchinga chofooka cha khungu, kufiira, ndi kuuma, PDRN yapamutu imapereka zizindikiro zowongolera bwino poyerekeza ndi zosakaniza wamba. Sichimachitira mwachindunji vutoli, koma imapanga microenvironment yabwino kuti khungu lidzikonzekeretse mwa kuchepetsa kutupa ndi kulimbikitsa kusiyana kwa thanzi la keratinocytes.

Mafuta ambiri opangira zida zapamwamba, ma seramu, kapena ma ampoules amawagwiritsa ntchito ngati chinthu chofunika kwambiri, kugogomezera "kulimbikitsa ndi kukonza" zotsatira zake "zoletsa kukalamba ndi kukhazikika".  Nthawi zambiri amaphatikizidwa ndi zotchinga zotchinga monga ceramides ndi centella asiatica extract kuti apititse patsogolo mphamvu zake, komanso amaphatikizidwa ndi antioxidants (monga SOD) kuti ateteze ku kuwonongeka kwa okosijeni pamene akukonza khungu.

Mapeto

PDRN si gimmick yotsatsa; zotsatira zake zotsutsana ndi kutupa ndi kubwezeretsa, pamodzi ndi chitetezo chake cha DNA, zimathandizidwa ndi njira zolimba zamoyo ndi deta yachipatala.  Phindu lake lalikulu likuwonetsedwa m'magwiritsidwe ntchito kuyambira kuchiritsa mabala achipatala kupita ku chisamaliro cha pambuyo pa zodzoladzola. Komabe, pamsika wogwira ntchito wa skincare, mitundu ina imachita zinthu zosokeretsa zamalonda, monga kukokomeza kuchulukira komanso zonena zogwira mtima.

Ogwiritsa ntchito ayenera kumvetsetsa kuti: PDRN yachipatala yachipatala (yojambulidwa / microneedled) imapereka zotsatira zowonongeka kwambiri ndipo ndizoyenera ku post-cosmetic process kapena zowonongeka kwambiri za khungu; Zopangira zapakhungu za PDRN zosamalira khungu ndizoyenera kukonzanso tsiku ndi tsiku komanso kukonza khungu lofewa, komanso zotsutsana ndi ukalamba komanso zoyera pakusamalira khungu. Kumvetsetsa koyenera kwazinthu zofunikira ndikofunikira kuti mupewe misampha yamalonda.