Impuguke zunvikana kubijyanye no kuvura kwa Acide ya PDRN Muri Dermatology 

Mu myaka yashize, aside polydeoxyribonucleic (PDRN) yitabiriwe n'abantu benshi mu bijyanye na dermatology, ariko haracyari ikibazo cyo kutumva kimwe ku bijyanye no gushyira mu bikorwa ikoreshwa ryayo. Itsinda rya Laser Cosmetology Itsinda ry’ishyirahamwe ry’ubuvuzi ry’Abashinwa ry’ishami ry’abaganga b’ubuvuzi bw’uburanga n’ububiko bwa Plastike hamwe n’itsinda ry’ubuvuzi Cosmetologiya ry’ishyirahamwe ry’abashinwa ry’ubuvuzi bw’ubuvuzi bw’ubushinwa ryasohoye hamwe “Impuguke z’impuguke zerekeye ivuriro ry’imiti ya Polydeoxyribonucleic Acide muri Dermatology,” igamije guha abaganga inama z’ubumenyi kandi zifatika zo kubayobora mu bikorwa bifatika kandi bifatika.

Pharmacokinetics na Mechanism yibikorwa bya PDRN

PDRN ibaho muri plasma muburyo bwubuntu kandi ntabwo ihuza na plasma apolipoproteine. Ikwirakwizwa ryayo rifitanye isano neza no gutembera kw'amaraso. Uyu muti ntabwo uhindurwa numwijima; yangirika cyane na plasma idasanzwe ya ADN nuclease cyangwa selile membrane nuclease kugirango ibe ingirakamaro, mononucleotide. Ubwanyuma, ibyinshi bisohoka mu nkari (hafi 65%), hamwe na bike bisohoka mumyanda.

Kwangirika kwa PDRN bitanga nucleotide na nucleoside, bitanga ibikoresho fatizo byo gusana ibyangiritse kuri ADN kandi bigateza imbere byihuse gusana ADN yangiritse no gukwirakwiza selile.

Gukoresha Clinical ya PDRN muri Dermatology

1. Gukiza ibikomere

Ubushakashatsi bugezweho bwerekanye ko PDRN igira uruhare mu gukiza ibikomere bivuye mu mpande nyinshi, harimo kubuza ibisubizo bikabije, kwihutisha ibyorezo bya epidermal na dermal, guteza imbere kolagene, no kugenzura angiogenezi hamwe n’ibindi bintu bigenga nka VEGF. Mu barwayi batera uruhu rwa autologique, inshinge, insimburangingo, cyangwa insimburangingo ya PDRN ahakomeretse irashobora kwihutisha ibikomere byongeye epithelialisation nigihe cyo gukira. Byongeye kandi, porogaramu ya PDRN nyuma yo kuvura lazeri ya CO2 irashobora kwihutisha gukira ibikomere; kubwibyo, PDRN irashobora gusuzumwa nyuma yo kuvura lazeri kugirango iteze gukira ibikomere no kugarura imikorere yinzitizi yuruhu.

2. Melasma na Post-inflammatory Hyperpigmentation:

Impamvu zisanzwe zitera melasma na hyperpigmentation ya post-inflammatory ahanini zirimo gukora bidasanzwe bya melanocytes hamwe nibisubizo bikomeza. PDRN irashobora kugenga inzira ya kinase na protein kinase B mugukoresha ibimenyetso bidasanzwe muri melanocytes, bikagabanya urwego rwibintu byandikirwa na dysplastic angiotensin bifitanye isano na transcription, bikabuza kwerekana proteine ​​zijyanye na tyrosinase na melanin synthesis, kandi bikagabanya melanine ya melanocytes. Mubuvuzi, PDRN irashobora gufatwa nkubundi buryo bwo kuvura indwara ziterwa na pigmentary nka melasma cyangwa hyperpigmentation ya post-inflammatory. 3. Gusaza k'uruhu:

PDRN ikora adenosine A2A yakira cyangwa inzira yo gukiza, igenga ubukana bwa cyclic adenosine monophosphate (cAMP), ikabuza MMPs na elastase gusohora, ikavugurura matrice idasanzwe, igabanya iminkanyari, igarura uruhu rwuruhu, kandi ikanonosora uruhu. Byongeye kandi, ubushakashatsi bwinshi bwerekanye ko PDRN ishobora kugabanya urwego rwibintu bitandukanye bitera inflammatory nka IL-6, IL-1β, TNF-α, na IL-12, kandi bikagenga ururenda rwibintu bitera nka IL-10. Ibi byerekana ko PDRN ishobora gutinza icyarimwe kugaragara no gutera imbere kwifoto yuruhu muguhagarika ururenda rwa SASP, kunoza uruhu rworoshye, kurwara, no kwangiza imyenge, no kugabanya gutakaza amazi ya transepidermal, bityo bikemura ibibazo byo gusaza kwuruhu.

4. Inkovu:

Mu buryo bwo gukiza imbeba ya SD, PDRN yasanze igabanya ingirabuzimafatizo zinjira mu ngingo z’inkovu kandi ikabuza ikwirakwizwa ry’inkovu nyinshi mu guhagarika imvugo ya HMGB-1. Ubushakashatsi mpuzamahanga bw’ubuvuzi bwerekanye ko gukoresha PDRN hakiri kare nyuma ya tiroyideyideyumu bishobora guteza imbere cyane imiterere, ibara, nubunini bwinkovu za hypertrophique, hamwe numutekano mwiza kandi nta ngaruka mbi. Kubwibyo, gutabara hakiri kare na PDRN birashobora gufatwa nkibikomere byugarije inkovu. Kugeza ubu, nta bushakashatsi bwakozwe ku mikorere ya PDRN muri keloide.

5. Andorogène Alopecia:

Abarwayi bafite alopeciya ya androgeneque bagaragaza impinduka zumutwe nko kugabanuka kwamaraso. PDRN irashobora kugenga inzira ya Wnt yerekana inzira, igatera imisatsi ikwirakwira, kandi igenzura VEGF nibindi bikoresho bya vasoactive, bityo igatera alopeciya ya androgeneque. Ubushakashatsi buteganijwe bwerekanye ko ku barwayi barwaye alopeciya ya androgeneque batitabira kuvura imiti isanzwe, gukoresha PDRN hamwe na PRP cyangwa 1927nm thulium fraction fraction laser bishobora kuba amahitamo. Nyamara, ingano nini yicyitegererezo iracyakenewe kugirango dusuzume umutekano.

6. Izindi ndwara zuruhu:

Abarwayi bafite alopeciya ya androgeneque bagaragaza impinduka zumutwe nko kugabanuka kwamaraso. PDRN irashobora kugenga inzira ya Wnt yerekana inzira, igatera imisatsi ikwirakwira, kandi igenzura VEGF nibindi bikoresho bya vasoactive, bityo igatera alopeciya ya androgeneque. Ubushakashatsi bugezweho bwerekana ko PDRN ifatanije na PRP cyangwa 1927nm thulium fractional laser ivura bishobora kuba amahitamo kubarwayi barwaye alopeciya ya androgeneque batitabira imiti isanzwe. Nyamara, ingano nini yicyitegererezo iracyakenewe kugirango isuzume umutekano wacyo.

Ikoreshwa

Imikoreshereze ya PDRN iratandukanye cyane n'indwara zitandukanye, kandi protocole ihuriweho iracyabura.

Kugeza ubu, ubuvanganzo bwo mu gihugu ndetse no mu mahanga butangaza uburyo bw'ubuyobozi bwa PDRN burimo gukoreshwa mu buryo bwihariye, kubyara imbere, gutera inshinge, gutera inshinge, no gutera inshinge. Inshuro zikoreshwa zingana kuva rimwe kumunsi kugeza rimwe mubyumweru, kandi igihe cyo kumara kiri hagati yiminsi myinshi nicyumweru. Ariko, uburyo bwihariye bwo gukoresha bugomba gukurikizwa cyane ukurikije ibicuruzwa (ibiyobyabwenge cyangwa ibikoresho byubuvuzi).

Umutekano no Kwirinda

1. PDRN ifite ADN isukuye> 95% kandi ntabwo irimo poroteyine zikora imiti cyangwa peptide, kubwibyo ubudahangarwa bwayo buri hasi.
2. Ubushakashatsi bwinshi bw’amavuriro bwemeje kandi ko PDRN ifite umutekano n’ubworoherane hatitawe ku nzira y'ubuyobozi. Nta ngaruka zikomeye z'uburozi cyangwa ingaruka zikomeye zagaragaye nyuma yo gukoreshwa ku ngingo, nubwo rimwe na rimwe byoroheje biterwa n'ingaruka nko gutukura uruhu, guhinda, no gukomeretsa bishobora kubaho. Ibi bimenyetso mubisanzwe bigabanuka vuba nyuma yo guhagarika imiti cyangwa kuvura ibimenyetso.
3. Hano haribishobora kubaho ibintu bibi nka granuloma yumubiri wamahanga nindwara zihariye mugihe PDRN itanzwe no gutera inshinge. Kubwibyo, ugomba kwitonda mugihe ukoresheje uyu muti imbere cyangwa munsi yubutaka.
4. PDRN yanduye ku bagore batwite n'abonsa, abafite ibikomere byanduye, ndetse na allergique kuri PDRN.

Incamake na Outlook

1. Mubushinwa, PDRN ikoreshwa cyane cyane kandi binyuze muri microneedling mesotherapy. Urebye ingaruka za PDRN zo kurwanya inflammatory hamwe nubushobozi bwo gusana ingirabuzimafatizo, ubushakashatsi buzaza burashobora gushakisha ubushobozi bwabwo mubikorwa bishya.
2. Byongeye kandi, ingamba zubuyobozi bwa PDRN mugukemura ibibazo bitandukanye byuruhu, harimo kumenya inzira nziza yubuyobozi, inshuro, hamwe nibitekerezo, hamwe ningaruka zayo hamwe nubundi buvuzi, bisaba ko hakorwa iperereza rindi.