Recombinant muntu superoxide dismutase (rhSOD): Intambwe nshya mubijyanye na antioxydants ihabwa ingufu na biotechnologie. 

Imibiri yacu isanzwe itanga superoxide disutase (SOD), ariko ibibazo byinshi byubuzima bwa none birenze ubushobozi bwayo. Kuzuza SOD ntabwo ari inyungu ziyongereye gusa, ahubwo ni imbaraga zikenewe kumubiri. Guhitamo inyongera ya SOD, ariko, igena imikorere numutekano byiyi mbaraga.

Mbere yo kuganira "kubyo twuzuza," tugomba kubanza kumva "impamvu tugomba kuzuza." Ibi ntibireba ubwiza gusa, ahubwo bireba n'amahame remezo yubuzima.

Ni ukubera iki ari ngombwa kongeramo superoxide disutase (SOD)?

Umubiri wumuntu ufite rwose "umurongo wo gukora SOD", ariko hamwe nimyaka hamwe nimpinduka mubuzima, "itangwa-ryinguzanyo-isabwa" ya SOD igenda isenyuka buhoro buhoro, biganisha ku gukabya gukabije kwa radicals, kwangiza imikorere yumubiri no kwihutisha gusaza.

1.Gusaza: SOD yumubiri ubwayo "umusaruro uragabanuka," kandi ubushobozi bwo gusiba buba buke.

Imyaka 25 ningingo ikomeye: Mbere yimyaka 25, igipimo cyumubiri wa SOD synthesis irashobora "gukomeza" byoroshye nigipimo cyumusaruro wubusa; icyakora, nyuma yimyaka 25, synthesis ya SOD igabanuka ku gipimo cya 1% -2% kumwaka. Ku myaka 40, ibikorwa bya SOD byumubiri ni 50% gusa murwego rwo hejuru, kandi nyuma yimyaka 60, ntibiri munsi ya 30%.

Hagati aho, umusaruro wa radicals yubuntu ntugabanuka-metabolisme selile nu guhumeka bikomeza kubyara superoxide anion yubusa. Ibi biganisha kuri SOD idahagije, kandi radicals zirenze urugero zitangira kwibasira selile: kwangiza uruhu rwa kolagen (gutera inkeke), kwangiza endotelium yimitsi (kwihuta gusaza kwamaraso), no guhagarika ingirabuzimafatizo (kongera umutwaro wa metabolike). Iyi ni imwe mu mpamvu zingenzi zitera "gusaza."

2.Ubuzima bwa none: Birenze urugero Byubusa, SOD ya Endogenous idahagije

Usibye imyaka, imibereho ya buri munsi nayo yihutisha umusaruro wa radicals yubuntu:

UV guhura: izuba riva kumasaha imwe kumunsi byongera radicals yubusa ikorwa nuruhu inshuro eshatu, bikarenza kure umubiri SOD (superoxide dismutase) yo gukuraho;

Ijoro ryijoro no guhangayika: Iyo ubuze ibitotsi cyangwa uhangayitse, umubiri urekura "imisemburo itera imbaraga," bigatuma habaho umusaruro mwinshi wa radicals yubusa;

Indyo mbi: Isukari nyinshi, ibinure byinshi, hamwe nibiribwa bikaranze bitanga umusaruro wa glycation wanyuma mugihe cya metabolism, uherekejwe numubare munini wa radicals yubusa;

Guhumanya ibidukikije: Ibintu byangiza umwotsi, umunaniro w’imodoka, n’umwotsi w’itabi, nyuma yo kwinjira mu mubiri w’umuntu, bitera "stress oxydeide", biganisha ku gukwirakwizwa kwa radicals yubuntu;

Ingaruka z'indwara: Imiterere ya pathologiya iterwa n'indwara n'inzira yo guhinduranya ibiyobyabwenge byombi byongera imbaraga za okiside mu mubiri, biba intandaro yo gukwirakwiza bidasanzwe kwa radicals z'ubuntu.

3.SOD yumubiri ubwayo ifite "ubushobozi buke" kandi ntishobora guhangana n "ibitero byibanda."

Ndetse no mu rubyiruko rufite ubuzima buzira umuze, SOD yumubiri ubwayo ifite aho igarukira: yibanda cyane mu ngirabuzimafatizo kandi itanga ubwishingizi budahagije bwo kurwanya radicals yubusa mu maraso no ku ruhu; byongeye kandi, ibikorwa byayo ntabwo biri hejuru bihagije kugirango bikureho burundu radicals yubusa mugihe "guturika cyane" (nka nyuma yizuba cyangwa imyitozo ikaze).

Aha niho huzuzwa SOD biba ngombwa-ni nko kongeramo "isuku ikora neza" mumubiri kugirango ifashe gukuraho byihuse radicals yubusa no kwirinda kwangirika kwingirabuzimafatizo.