PDRN ni iki? Ni ukubera iki bifatwa nk '“urufunguzo rw'ubuvuzi bushya”? 

Mu rwego rwo kwita ku ruhu nubuvuzi bwiza, "kuvugurura" ni igitekerezo gishimishije. Iyo uruhu rwangiritse cyangwa rwashaje, burigihe twizera kubyutsa ubushobozi bwarwo bwo gusana. PDRN nukuri "urufunguzo" umuryango wubumenyi uherutse kuvumbura kugirango ukore neza inzira yo gusana selile. Uyu munsi, tuzashyira ahagaragara amabanga yacyo.

Inkomoko: Guhumeka biturutse ku mbaraga zo kuvugurura inyanja

PDRN (Polydeoxyribonucleotide), izina ryayo ryuzuye ni polydeoxyribonucleotide, ntabwo ari ibicuruzwa bivangwa na chimique, ahubwo biva mu ngirabuzimafatizo za salmon naturel.

Abahanga bavumbuye ko salmon ifite imbaraga zikomeye zo kuvugurura no gusana. Binyuze mu bundi bushakashatsi, bakuyemo igice cyihariye cya ADN-PDRN-intanga za salmon. Iyi ADN irasa cyane muburyo bwibanze na ADN y’inyamabere zose (harimo n’abantu), zigaragaza ibinyabuzima bihuza neza kandi bikaba bifite ingaruka nke zo kwangwa n’umubiri, bityo bigatuma ikoreshwa neza kandi neza mu mubiri w’umuntu.

Ibyingenzi: Ntabwo ari "ibikoresho fatizo" gusa, ahubwo ni "ikimenyetso."

Turashobora gusobanukirwa nuburyo bwibikorwa bya PDRN duhereye kubintu bibiri byingenzi:

Nka "ibikoresho byo gusana": PDRN igizwe na deoxyribonucleotide nyinshi (ibice shingiro bya ADN). Iyo ingirangingo zuruhu zangiritse kandi selile zigomba kugabana no kwiyongera kugirango zirangire neza, izo nucleotide ziboneka byoroshye zishobora gukoreshwa ningirabuzimafatizo nkibikoresho fatizo byo guhuza ADN nshya, bityo byihutisha inzira yo gusana.

Nka "ikimenyetso cyo gusana": Ubu ni uburyo bukomeye kandi budasanzwe bwibikorwa bya PDRN. PDRN irashobora kumenyekana byumwihariko na selile ikikije tissue yangiritse cyangwa hypoxic hanyuma igahuza na reseptor ya adenosine A2A hejuru yakagari, ikabuza inzira ya NF-kB na MAPK yerekana inzira ikoreshwa na ROS.  Ibi bigabanya umusaruro wa cytokine itera umuriro (IL-6, IL-1β, TNF-α, nibindi) kandi bigatera imbere kwerekana cytokine irwanya inflammatory (IL-10), bityo bikagira ingaruka zikomeye zo kurwanya inflammatory.  Byongeye kandi, itera ururenda rwa EGF (gukura kwa epidermal), FGF (gukura kwa fibroblast), VEGF (imikurire yimitsi iva mu mitsi), na angiopoietin, igaha PDRN ibintu byiza byo kurwanya no gukiza ibikomere.

Imikorere yibanze: Urunigi rwo gusana kuva kuri micro kugeza kurwego rwa macro.

Ukurikije uburyo bwasobanuwe haruguru, PDRN ikora urukurikirane rwingaruka nziza zifitanye isano kurwego rwuruhu:

Itera angiogenezi: Yongera amaraso ahantu yangiritse, ikazana ogisijeni nintungamubiri nyinshi no gukuraho imyanda ya metabolike.

Guteza imbere ikwirakwizwa ryimuka no kwimuka: Kwihutisha ibikorwa numubare wingenzi wogusana nka fibroblast na keratinocytes.

Ikangura synthesis ya kolagen na elastin: Ikomeza imiterere yuruhu kuva dermis, kunoza imirongo myiza no kongera elastique.

Ingaruka zikomeye zo kurwanya inflammatory: Kugabanya neza ingaruka ziterwa no gutwika nko gutukura, kubyimba, ubushyuhe, nububabare muguhindura ibintu bitera umuriro.

Gusana imyenda no gukira ibikomere: Uhujije ingaruka zose zavuzwe haruguru, byihutisha cyane inzira yo gukira ibikomere bitandukanye byuruhu.

PDRN ivugwa nk "urufunguzo rwo kuvuka bundi bushya" kuko idasana gusa kandi igaburira, ahubwo igenga imikorere yimikorere.  Ukurikije ibinyabuzima bihanitse cyane, ikora imbaraga zuruhu rwonyine rushobora kubyara binyuze mumihanda myinshi. Ubu buryo bwo "gukangura ubushobozi bwo gusana imbere" nicyo kintu nyamukuru gikurikirana mubijyanye no kuvuka bushya, kandi nicyo giha PDRN umwanya wacyo udasimburwa mubijyanye nubuzima bwuruhu.