Kumenyekanisha PDRN: Ibi birashakishwa cyane muburyo bwo kuvura uruhu nibintu byo kwamamaza cyangwa bitanga ibisubizo koko? 

Vuba aha, PDRN (polydeoxyribonucleotide) yagaragaye kenshi mubikoresho byamamaza byo kuvura uruhu rukora nibicuruzwa byiza byubuvuzi.  Ibirango nka "salmon ADN inshinge" na "ADN yo gusana urwego" byahise bikundwa cyane, ariko kandi byateje impaka: Ese iyi ni gimmick yo kwamamaza gusa yashizweho nigishoro, cyangwa nikintu gifatika gifatika gifite inyungu nyinshi? Iyi ngingo izasesengura agaciro nyako ka PDRN duhereye kubumenyi, ihuza ubushakashatsi bwamavuriro namakuru yinganda zikoreshwa.

Igisobanuro cyibanze na logique ikora ya PDRN

PDRN ni polymer yakozwe na deoxyribonucleotide ihujwe na fosifori ya fosifori, hamwe nuburemere bwa molekile kuva kuri 50 kugeza 1500 kDa. Igikorwa cyibanze cyibinyabuzima gikomoka kumiterere ya adenosine. Kugeza ubu, ibikoresho fatizo byujuje ibyangombwa bivanwa cyane mu ngirabuzimafatizo y’imyororokere ya salmon, ariko birashobora no gutegurwa hifashishijwe fermentation ya mikorobe hamwe nubuhanga bw’ibinyabuzima bwa sintetike, kandi bigasaba ibizamini byinshi kugirango isukari ya nucleique isukure nibikorwa byibinyabuzima.

Uburyo bwibikorwa bifite ishingiro ryibinyabuzima, bigabanijwemo inzira ebyiri:

1.Anti-inflammatory inzira igenga: Nka adenosine A2A reseptor agonist, irashobora kugenzura neza ibintu birwanya inflammatory IL-10 no kugabanya ibintu bitera inflammatory IL-6 na TNF-α, kuringaniza ibidukikije byuruhu no kubuza kwangirika kwa okiside;

2.Gusana n'inzira ya synthesis: Nka nucleotide ibanziriza synthesis ya ADN selile, irashobora gutanga ibikoresho fatizo byo kongera ibikoresho bya genetike mungirangingo zangiritse, kwihutisha ikwirakwizwa rya epidermal no gusana inzitizi. Ubu buryo bwagenzuwe muri byinshi mu bushakashatsi bwa vitro selile nubushakashatsi bwubuvuzi.

Kugenzura imikorere: Imikorere yibanze ishyigikiwe nubushakashatsi.

1.Isanwa rya barrière hamwe no Kurwanya Kurwanya: Ibyiza bya Clinical Byagaragaye

Mu rwego rwa dermatology, PDRN ifite amakuru asobanutse ashyigikira imikorere yayo mugutezimbere inzitizi nibibazo byuruhu. Ubuvuzi bwa Clinical bwerekana ko imyiteguro irimo PDRN ishobora kunoza cyane ibimenyetso byumutuku muri rosacea ya erythematotelangiectatic, ugereranije wagabanutseho 32.7% mugace ka erythema nyuma yibyumweru 4 byakoreshejwe; kubikomere nyuma yo kwisiga, birashobora kugabanya igihe cyo gukiza epidermal 20% kugeza 30%, kandi bikagabanya umutuku nyuma yibikorwa, kubyimba, ubushyuhe, nububabare.

Ikigeretse kuri ibyo, mubigeragezo byibanze kuri dermatite ya atopic, PDRN yagabanije amanota yo kwanduza uruhu kandi yongerera ingufu za stratum corneum. Ntabwo ari kwamamaza jargon, ahubwo ni uburyo butaziguye bwo kurwanya no gutwika.

2.Kwera no Kurwanya gusaza: Byerekanwe Gukora Kubitera Imizi

Ubushakashatsi bwakozwe na vitro selile bwemeje ko PDRN ishobora guhagarika ibikorwa bya tyrosinase (igipimo cyo kubuza hafi 28%), kugabanya imvugo ya poroteyine zigenga melanine nka MITF, no kugabanya umusaruro wa melanine; icyarimwe, irashobora kongera ibikorwa bya fibroblast mitochondrial, ikabuza matrix metalloproteinase MMP-1, kandi igateza imbere synthesis.

3.Kurinda Photodamage: Intego yo gusana urwego rwa ADN

Nyuma yo kurasa UV, selile zuruhu zangirika ADN. PDRN irashobora gukora byihuse inzira ya proteine ​​ya p53 kugirango itangire uburyo bwo gusana ADN, kugabanya ihinduka ryimiterere ya gene iterwa na UV, no kugabanya ibyago byo gufotora no gufotora. Ingaruka zagenzuwe mubigeragezo byerekana ingirabuzimafatizo kandi nimwe mubyiza byingenzi bitandukanya nibintu bisanzwe birwanya antioxydeant.

Ahantu ho gusaba: kuva mubuvuzi bukenewe kugeza kwaguka mubikorwa byo kuvura uruhu.

Ikoreshwa rya PDRN ntabwo ryatangiranye no kwamamaza uruhu; agaciro kayo kamenyekanye bwa mbere mubijyanye n'ubuvuzi, hanyuma nyuma buhoro buhoro bwiyongera buhoro buhoro mubuvuzi bwiza no kuvura uruhu rukora. Imikorere muburyo butandukanye ifite imipaka isobanutse.

1.Ubuvuzi:

Nko mu 2008, isosiyete yo mu Butaliyani Mastelli yatangije inshinge ya mbere y’imiti ya PDRN, Placentex, yakoreshejwe mu gusana ibikomere bidakira (ibisebe by’ibirenge bya diyabete, gutwika ibikomere), kwangirika kwa corneal, no kwangiza amagufwa. Amavuriro yerekana ko igipimo cyayo cyiza mugukiza ibikomere bigoye-gukira bishobora kugera kuri 76.5%, bigatuma kiba ibikoresho byifashishwa mubuvuzi byemewe byo gusana ingirangingo.

2.Ubuvuzi bwiza bwubuvuzi:

Mu rwego rwubuvuzi bwiza, PDRN ikunze kwitwa "ADN ya salmon" kubera ibikoresho byayo kandi ikoreshwa cyane muri mesotherapie no gusana nyuma ya microneedling. Ikigo gishinzwe ibiryo n'ibiyobyabwenge muri Koreya (KFDA) cyashyizemo nk'ibikoresho byujuje ibisabwa mu guhindagura ingirangingo no kuvura ibikomere mu mwaka wa 2008, byihutisha gukira ibikomere byibasiye cyane mu bwiza bw’ubuvuzi, kunoza umutuku mu ruhu rworoshye ndetse no ku ruhu rukabije. Ingaruka zacyo zagenzuwe nibitekerezo byubuvuzi bivuye mubigo byubuvuzi bwiza.

3.Umurima ukora neza uruhu:

Hamwe niterambere ryikoranabuhanga, PDRN yinjijwe neza mubicuruzwa byita ku ruhu. Kubibazo byuruhu biterwa no kweza cyane, ibishishwa byimiti, cyangwa kuvura nyuma ya laser, nkinzitizi zuruhu rwacitse intege, gutukura, no gukama, PDRN yibanze itanga ibimenyetso byiza byo gusana ugereranije nibintu bisanzwe bitanga amazi. Ntabwo "ivura" ikibazo mu buryo butaziguye, ahubwo ikora microen ibidukikije nziza yo kwikosora uruhu mukugabanya gucana no guteza imbere itandukaniro ryiza rya keratinocytes.

Amavuta menshi yo mu rwego rwo hejuru yo gusana, serumu, cyangwa ampules ayikoresha nkibintu byingenzi, ashimangira ingaruka zayo "gushimangira no gusana" na "kurwanya gusaza no gutuza".  Bikunze guhuzwa nibikoresho byo gusana inzitizi nka ceramide na centella asiatica ikuramo kugirango yongere imbaraga zayo, kandi igahuzwa na antioxydants (nka SOD) kugirango irinde kwangirika kwa okiside mugihe cyo gusana uruhu.

Umwanzuro

PDRN ntabwo ari ibicuruzwa byo kwamamaza; Ingaruka zayo zo kurwanya no kwishura, hamwe no kurinda urwego rwa ADN, zishyigikirwa nuburyo bukomeye bwibinyabuzima hamwe namakuru yubuvuzi.  Agaciro kayo kerekanwa mubikorwa uhereye ku gukomeretsa kwa muganga kugeza nyuma yo kwisiga. Nyamara, mu isoko ryita ku ruhu rukora, ibirango bimwe na bimwe bishora mu bikorwa byo kuyobya uburari, nko gukabiriza kwibanda hamwe n’ibisabwa.

Abaguzi bagomba kumva ko: PDRN yo mu rwego rwubuvuzi (yatewe / microneedled) itanga ingaruka zikomeye zo kwisubiraho kandi irakwiriye uburyo bwo kwisiga cyangwa kwisiga byangiritse cyane; ibintu byingenzi bya PDRN byita kuruhu bikwiranye no gusana buri munsi no gufata neza uruhu rworoshye, kimwe no kurwanya gusaza no kwera muguvura uruhu. Gusobanukirwa gushyira mu gaciro agaciro kingenzi ningirakamaro kugirango wirinde imitego yo kwamamaza.