Nyanzvi Kubvumirana PaKliniki Yekushandisa kwePDRN Acid MuDermatology 

Mumakore achangopfuura, polydeoxyribonucleic acid (PDRN) yakawana kutariswa kwakapararira uye kushandiswa mundima yedermatology, asi pachine kushomeka kwekunzwisisa kwakabatana maererano nekumisikidzwa kwekushandiswa kwayo. Laser Cosmetology Boka reChinese Medical Association's Bazi reAesthetic uye Plastic Surgeons uye Medical Cosmetology Boka reChinese Association of Integrative Medicine vakabatana vakapa "Nyanzvi Consensus paClinical Application yePolydeoxyribonucleic Acid muDermatology," nechinangwa chekupa varapi zano resainzi uye rine chinangwa chekutungamira mukushandisa zvine musoro muRNN.

Pharmacokinetics uye Mechanism Yekuita kwePDRN

PDRN iripo muplasma mune fomu yakasununguka uye haisungiri ku plasma apolipoproteins. Kugoverwa kwayo kunobatanidza zvakanaka nekuyerera kweropa retishu. Ichi chinodhaka hachina metabolized nechiropa; inonyanya kuderedzwa ne-non-specific plasma DNA nucleases kana cell membrane nucleases kuti iite chinhu chinoshanda, mononucleotide. Pakupedzisira, yakawanda yacho inobudiswa muweti (inenge 65%), ine chidimbu chiduku chinobudiswa mumarara.

Kushatisa kwePDN kunogadzira nucleotides uye nucleosides, ichipa zviwanikwa zveDNA kukuvara kugadzirisa uye nekukurumidza kukurudzira kugadziriswa kweakakuvadzwa sero DNA uye kuwanda kwesero.

Clinical Kushandisa kwePDN muDermatology

1. Kuporeswa Kwemaronda

Tsvagiridzo yemazuva ano yakawana kuti PDRN inotora chikamu mukurapa maronda kubva kumakona akawanda, kusanganisira kuvharidzira mhinduro dzekuzvimba, kukurumidza epidermal uye dermal renewal, kusimudzira collagen deposition, uye upregulating angiogenesis uye zvimwe zvinodzora zvinhu zvakaita seVEGF. Mune autologous skin graft varwere, intramuscular, subcutaneous, kana topical PDRN majekiseni panzvimbo yeronda anogona kukurumidza ronda re-epithelialization uye nguva yekuporesa. Uyezve, PDRN kushandiswa mushure me CO2 fractional laser kurapwa kunogona kukurumidza kuporesa maronda; saka, PDRN inogona kutariswa mushure meablative laser kurapwa kukurudzira kuporeswa kweronda uye kudzoreredza ganda barriers basa.

2. Melasma uye Post-kuzvimba Hyperpigmentation:

Izvo zvinowanzokonzera melasma uye post-kuzvimba hyperpigmentation zvinonyanya zvinosanganisira abnormal activation ye melanocytes uye kuramba kuzvimba mhinduro. PDRN inogona kudzora kinase uye protein kinase B nzira nekuita kuti extracellular siginecha mu melanocytes, ichidzikisire mazinga e dysplastic angiotensin-ane chekuita nekunyora zvinhu, ichivharira kutaura kwe tyrosinase uye melanin synthesis-ane hukama mapuroteni, uye kuderedza melanin yemukati memelanocytes. Muchipatara, PDRN inogona kutariswa pamwe chete nedzimwe nzira dzekurapa refractory pigmentary kusagadzikana senge melasma kana post-kuzvimba hyperpigmentation. 3. Kuchembera Kweganda:

PDRN inoshandisa adenosine A2A receptors kana nzira dzekuchengetedza, inosimudza cyclic adenosine monophosphate (cAMP) concentration, inhibits MMPs uye elastase secretion, inogadzirisa matrix e-extracellular, inoderedza wrinkles, inodzorera ganda, uye inovandudza ganda. Uyezve, zvidzidzo zvakawanda zvakawana kuti PDRN inogona kuderedza mazinga ezvakasiyana-siyana zvinokonzera-kupisa zvakadai se IL-6, IL-1β, TNF-α, uye IL-12, uye inogadzirisa kuvharidzirwa kwezvinhu zvinopisa zvakadai seIL-10. Izvi zvinoratidza kuti PDRN inogona panguva imwe chete kunonoka kuitika uye kukura kweganda photoaging nekudzivisa SASP secretion, kuvandudza ganda elasticity, roughness, uye akawedzera pores, uye kuderedza transepidermal kurasikirwa mvura, nokudaro kugadzirisa ganda kukwegura matambudziko.

4. Scarring:

Mune SD rat incision yekuporesa modhi, PDRN yakawanikwa ichideredza kuzvimba kwesero kupinza mukati mevanga matishu uye kuvharidzira kuwanda kwevanga nekudzivisa HMGB-1 kutaura. Ongororo dzekiriniki dzepasi rose dzakaona kuti kushandiswa kwekutanga kwePDN mushure mekutapurwa kwethyroid kunogona kuvandudza zvakanyanya maumbirwo, ruvara, uye saizi ye hypertrophic mavanga, nekuchengetedza kwakanaka uye pasina maitiro akashata. Naizvozvo, kupindira kwekutanga nePDRN kunogona kutariswa kune maronda ari panjodzi yekukuvara. Parizvino, hapana zvidzidzo pamusoro pekushanda kwePDRN mu keloids.

5. Androgenetic alopecia:

Varwere vane androgenetic alopecia vanoratidza scalp shanduko seyakaderedzwa uye miniaturized tsinga dzeropa. PDRN inogona kugadzirisa nzira yeWnt yekusaina, kukurudzira kupararira kwebvudzi, uye kukwidza VEGF nemamwe vasoactive agents, nokudaro kuvandudza androgenetic alopecia. Zvidzidzo zvinotarisirwa zvakawana kuti kune varwere vane androgenetic alopecia vasingapinduri kumishonga yemishonga, kushandiswa kwePDRN yakasanganiswa nePRP kana 1927nm thulium fractional laser treatment inogona kuva sarudzo. Nekudaro, saizi yakakura yemuenzaniso ichiri kudikanwa kuti uongorore kuchengeteka.

6. Zvimwe Zvirwere Zveganda:

Varwere vane androgenetic alopecia vanoratidza scalp shanduko seyakaderedzwa uye miniaturized tsinga dzeropa. PDRN inogona kugadzirisa nzira yeWnt yekusaina, kukurudzira kupararira kwebvudzi, uye kukwidza VEGF nemamwe vasoactive agents, nokudaro kuvandudza androgenetic alopecia. Zvidzidzo zvezvino zvinotarisirwa zvakaratidza kuti PDRN yakasanganiswa nePRP kana 1927nm thulium fractional laser treatment inogona kuva sarudzo inogona kuitirwa varwere vane androgenetic alopecia vasingapindure kune yakajairika mishonga yemishonga. Nekudaro, saizi yakakura yemuenzaniso ichiri kudikanwa kuti iongorore kuchengetedzwa kwayo.

Inokurudzirwa Kushandisa

Iko kushandiswa kwePDRN kunosiyana zvakanyanya pazvirwere zvakasiyana, uye yakabatana application protocol ichiri kushaikwa.

Parizvino, mabhuku epamba neekunze anoshuma nzira dzekutonga dzePDN dzinosanganisira topical application, intradermal delivery, intradermal jekiseni, subcutaneous jekiseni, uye intramuscular jekiseni. Kuwanda kwedosi kunobva kamwe pazuva kusvika kamwe chete pavhiki, uye dosing durations inotangira mazuva akati wandei kusvika mavhiki akati wandei. Nekudaro, nzira dzekushandisa dzakanangana dzinofanirwa kuteedzerwa zvakanyatsoenderana nechikamu chechigadzirwa (mushonga kana mudziyo wekurapa).

Chengetedzo uye Dziviriro

1. PDRN ine DNA kuchena> 95% uye haina pharmacologically inoshanda mapuroteni kana peptides, saka immunogenicity yayo yakaderera.
2. Zvidzidzo zvakawanda zvekiriniki zvakasimbisawo kuti PDRN ine kuchengetedzwa kwakanaka uye kushivirira zvisinei negwara rekutonga. Hapana huturu hwechepfu kana kukanganisa kwakakomba kwakaonekwa mushure mekushandiswa kwemusoro, kunyangwe dzimwe nguva maitiro akapfava akadai sekutsvuka kweganda, itching, uye kuruma kunogona kuitika. Zviratidzo izvi zvinowanzopera nekukurumidza mushure mekurega kushandisa mushonga kana nekurapwa kwezviratidzo.
3. Pane mukana wezviitiko zvakashata senge granulomas yemuviri wekune dzimwe nyika uye hutachiona chaihwo apo PDRN inobatwa nejekiseni. Nokudaro, kuchenjerera kunofanira kushandiswa paunenge uchishandisa mushonga uyu intradermally kana subcutaneously.
4. PDRN inopesana nevakadzi vane pamuviri uye vanoyamwisa, avo vane maronda ane utachiona, uye avo vanorwara nePDRN.

Pfupiso uye Outlook

1. MuChina, PDRN inonyanya kushandiswa pamusoro uye kuburikidza ne microneedling mesotherapy. Tichifunga nezve PDRN's inopesana nekuzvimba mhedzisiro uye matishu kugadzirisa-kusimudzira kugona, tsvakiridzo yeramangwana inogona kuongorora kugona kwayo kwekushandisa kwehunyanzvi.
2. Uyezve, maitiro ekutonga ePDRN mukurapa kwakasiyana siyana matambudziko eganda, kusanganisira kuona iyo yakakwana nzira yekutonga, frequency, uye yekuisa pfungwa, pamwe neiyo synergistic mhedzisiro nemamwe marapirwo, inoda kumwe kuferefetwa.