Recombinant human superoxide dismutase (rhSOD): Kubudirira kutsva mumunda we antioxidants inopihwa simba nebiotechnology. 

Miviri yedu inongogadzira superoxide dismutase (SOD), asi matambudziko mazhinji ehupenyu hwemazuva ano anokurira kugona kwayo. Kuwedzera neSOD hakusi kungowedzera bhenefiti, asi kusimbaradzwa kwakakodzera kwemuviri. Sarudzo yeSOD yekuwedzera, zvisinei, inosarudza kushanda uye kuchengetedzwa kwekusimbisa uku.

Tisati takurukura "zvekuwedzera," tinofanira kutanga tanzwisisa "sei tichifanira kuwedzera." Izvi hazvisi chete pamusoro pekunaka, asiwo pamusoro pemitemo inokosha yehutano.

Nei zvichidikanwa kuwedzera ne superoxide dismutase (SOD)?

Muviri wemunhu zvechokwadi une yavo "SOD yekugadzira mutsara," asi nezera uye shanduko yemararamiro, iyo "supply-demand balance" yeSOD inoputsika zvishoma nezvishoma, zvichitungamira kune kuwanda kwemahara radicals, kukuvadza mabasa emuviri uye kukurumidza kuchembera.

1.Kuchembera:  Sod yemuviri pachayo "kugadzirwa kunodzikira," uye kugona kwayo kwekutsvaira kunogumira.

Zera 25 ipfungwa yakakosha: Pamberi pemakore makumi maviri nemashanu, chiyero chemuviri cheSOD synthesis chinogona "kuchengeta" nechiyero chemahara radical kugadzirwa; zvisinei, mushure mezera re25, SOD synthesis inoderera pamwero we1% -2% pagore. Nezera remakumi mana, chiitiko cheSOD chemuviri wega chinongova 50% chepamusoro-soro, uye mushure memakore makumi matanhatu, iri pasi pe30%.

Zvichakadaro, kugadzirwa kwemahara radicals hakudzike-sero metabolism uye kufema kunoramba kuchiburitsa superoxide anion free radicals. Izvi zvinotungamirira kusakwana kweSOD, uye kuwandisa kwemahara radicals kunotanga kurwisa masero: kukuvadza ganda collagen (kukonzera wrinkles), kukuvadza vascular endothelium (kukurumidza vascular kukwegura), uye oxidizing masero echiropa (kuwedzera metabolic mutoro). Ichi ndicho chimwe chezvikonzero zvakakosha zve "kukwegura."

2.Modern Life: Yakawandisa Mahara Radicals, Insufficient Endogenous SOD

Kunze kwezera, mararamiro ezuva nezuva anowedzerawo kugadzirwa kwemahara radicals:

Kuratidzwa kweUV: Kuratidzwa kwezuva kweawa imwe pazuva kunowedzera mahara radicals anogadzirwa neganda kanokwana katatu, kupfuura iyo yega SOD yemuviri (superoxide dismutase) kuchenesa simba;

Husiku hwekupedzisira uye kushungurudzika: Kana kurara-kunyimwa kana pasi pekunetseka, muviri unobudisa "mahomoni ekushungurudzika," achikurudzira kugadzirwa kwenhamba yakawanda yemahara radicals;

Zvokudya zvisina kunaka: Shuga, mafuta akawanda, uye zvakakangwa zvokudya zvinobudisa zvigadzirwa zvekupedzisira zveglycation panguva yemetabolism, pamwe chete nenhamba yakawanda yemahara radicals;

Kusvibiswa kwezvakatipoteredza: Zvinhu zvinokuvadza muutsi, mhepo yemotokari, uye chiutsi chechipiri, mushure mekupinda mumuviri womunhu, zvinokonzera "oxidative stress," zvichiita kuti kupararira kwemahara radicals;

Chirwere kukanganisa: Pathological mamiriro anokonzerwa nehurwere uye muitiro wemetabolism yezvinodhaka zvese zvinowedzera kushushikana kweoxidative mumuviri, zvichiva madhiraivha akakosha ekuwedzera kusingawanzo kwemahara radicals.

3.Muviri weSOD pachawo une "ushoma simba" uye haugoni kutarisana ne "concentrated attack."

Kunyangwe kune vechidiki vane mararamiro ane hutano, iyo SOD yemuviri pachayo ine miganhu yayo: inonyanya kuiswa mukati memasero uye inopa kusakwana kuvharwa kune mahara radicals muropa uye pamusoro peganda; uyezve, basa rayo harina kukwirira zvakakwana kuti ribudirire kubvisa mahara radicals panguva ye "concentrated bursts" (senge mushure mekubuda kwezuva kana kurovedza muviri kwakasimba).

Apa ndipo panodiwa kuwedzera neSOD-zvakaita sekuwedzera "zvinochenesa zvakanyanya" kumuviri kubatsira nekukasira kubvisa akawandisa emahara radicals uye kudzivirira kuenderera kwesero kukuvara.