Tumellano ea Setsebi Mabapi le Tšebeliso ea Tleliniki ea PDRN Acid ho Dermatology 

Lilemong tsa morao tjena, polydeoxyribonucleic acid (PDRN) e fumane tlhokomelo e pharaletseng le ts'ebeliso lefapheng la dermatology, empa ho ntse ho e-na le khaello ea kutloisiso e kopaneng mabapi le maemo a ts'ebeliso ea eona. Sehlopha sa Laser Cosmetology sa Lekala la China Medical Association of Aesthetic and Plastic Surgeons le Medical Cosmetology Group of the Chinese Association of Integrative Medicine ka kopanelo li fane ka "Expert Consensus on the Clinical Application of Polydeoxyribonucleic Acid in Dermatology," ka sepheo sa ho fa lingaka likeletso tsa mahlale le sepheo sa ho ba tataisa ts'ebelisong e nepahetseng ea PD.

Pharmacokinetics le Mechanism of Action ea PDRN

PDRN e teng ka plasma ka mokhoa o sa lefelloeng 'me ha e tlame ho plasma apolipoprotein. Kabo ea eona e amana hantle le phallo ea mali ea lisele. Setlhare sena ha se na metabolized ke sebete; haholo-holo e senyeha ke li-nuclease tsa plasma tsa plasma tse sa tobang kapa li-nuclease tsa lisele tsa lisele ho etsa motsoako o sebetsang, mononucleotide. Qetellong, boholo ba eona bo ntšoa ka har'a moroto (hoo e ka bang 65%), 'me ho na le palo e nyane e ntšitsoeng mantleng.

Ho senyeha ha PDRN ho hlahisa li-nucleotide le nucleosides, ho fana ka lisebelisoa tse tala bakeng sa tokiso ea tšenyo ea DNA le ho khothalletsa ka potlako tokiso ea DNA ea lisele tse senyehileng le ho ata ha lisele.

Tšebeliso ea Clinical ea PRN ho Dermatology

1. Pholiso ea Leqeba

Lipatlisiso tsa morao-rao li fumane hore PDRN e kenya letsoho ts'ebetsong ea ho folisa leqeba ho tloha mahlakoreng a mangata, ho kenyelletsa le ho thibela likarabo tse feteletseng tsa ho ruruha, ho potlakisa ho tsosolosoa ha letlalo le letlalo, ho khothalletsa ho kenngoa ha collagen, le ho phahamisa angiogenesis le lintlha tse ling tsa taolo tse kang VEGF. Ho bakuli ba letlalo la autologous, liente tsa intramuscular, subcutaneous, kapa topical PDRN sebakeng sa leqeba li ka potlakisa ho khutlisa leqeba le nako ea ho folisa. Ho feta moo, kopo ea PDRN ka mor'a phekolo ea laser ea CO2 e fokolang e ka potlakisa ho folisa maqeba; ka hona, PDRN e ka nkoa ka mor'a phekolo ea laser ea ablative ho khothalletsa pholiso ea maqeba le ho tsosolosa ts'ebetso ea thibelo ea letlalo.

2. Hyperpigmentation ea Melasma le ka mor'a ho ruruha:

Lisosa tse tloaelehileng tsa melasma le hyperpigmentation ea kamora ho ruruha haholo-holo li kenyelletsa ts'ebetso e sa tloaelehang ea melanocyte le likarabo tse sa feleng tsa ho ruruha. PDRN e ka laola litsela tsa kinase le protheine kinase B ka ho kenya tšebetsong lipontšo tsa extracellular melanocyte, ho theola maemo a dysplastic angiotensin-a amanang le transcript factor, e thibelang polelo ea liprotheine tse amanang le tyrosinase le melanin synthesis, le ho fokotsa melanin ea melanocyte. Ka mokhoa oa bongaka, PDRN e ka nkoa e kopane le mekhoa e meng ea ho phekola mafu a refractory pigmentary a kang melasma kapa post-inflammatory hyperpigmentation. 3. Botsofali ba Letlalo:

PDRN e kenya tšebetsong li-receptor tsa adenosine A2A kapa litsela tsa salvage, e phahamisa mahloriso a cyclic adenosine monophosphate (cAMP), e thibela MMPs le elastase secretion, e lokisa matrix a extracellular, e fokotsa wrinkles, e tsosolosa letlalo la elasticity, 'me e ntlafatsa letlalo la letlalo. Ho feta moo, liphuputso tse ngata li fumane hore PDRN e ka fokotsa maemo a mefuta e sa tšoaneng ea pro-inflammatory e kang IL-6, IL-1β, TNF-α, le IL-12, le ho laola secretion ea mabaka a ho ruruha a kang IL-10. Sena se bontša hore PDRN ka nako e le 'ngoe e ka liehisa ketsahalo le nts'etsopele ea letlalo la photoaging ka ho thibela SASP secretion, ho ntlafatsa letlalo elasticity, roughness, le li-pores tse atolositsoeng, le ho fokotsa tahlehelo ea metsi a transepidermal, kahoo ho rarolla mathata a ho tsofala ha letlalo.

4. Scarring:

Moetsong oa pholiso oa SD rat incision, PDRN e ile ea fumanoa e fokotsa ho kenella ha lisele tse ruruhang ka har'a maqeba le ho thibela ho ata ho feteletseng ka ho thibela polelo ea HMGB-1. Liphuputso tsa bongaka tsa machaba li fumane hore tšebeliso ea pele ea PDRN ka mor'a thyroidectomy e ka ntlafatsa haholo sebopeho, 'mala, le boholo ba maqeba a hypertrophic, ka polokeho e ntle le ho se na liphello tse mpe. Ka hona, ho kenella pele ho nako le PDRN ho ka nkoa e le maqeba a kotsing ea ho senya. Hajoale, ha ho na lithuto tse mabapi le katleho ea PDRN ho keloids.

5. Androgenetic Alopecia:

Bakuli ba nang le androgenetic alopecia ba bonts'a liphetoho tsa letlalo la hlooho joalo ka methapo ea mali e fokotsehileng le e nyane. PDRN e ka laola tsela ea pontšo ea Wnt, e khothalletsa ho ata ha moriri oa moriri, le ho phahamisa VEGF le lisebelisoa tse ling tsa vasoactive, kahoo e ntlafatsa alopecia ea androgenetic. Liphuputso tse lebelletsoeng li fumane hore ho bakuli ba nang le alopecia ea androgenetic ba sa arabeleng kalafo e tloaelehileng ea lithethefatsi, tšebeliso ea PDRN e kopantsoeng le PRP kapa 1927nm thulium fractional laser treatment e ka ba khetho e ka bang teng. Leha ho le joalo, boholo ba lisampole bo boholo bo ntse bo hlokahala ho lekola polokeho.

6. Mafu a mang a Letlalo:

Bakuli ba nang le androgenetic alopecia ba bonts'a liphetoho tsa letlalo la hlooho joalo ka methapo ea mali e fokotsehileng le e nyane. PDRN e ka laola tsela ea pontšo ea Wnt, e khothalletsa ho ata ha moriri oa moriri, le ho phahamisa VEGF le lisebelisoa tse ling tsa vasoactive, kahoo e ntlafatsa alopecia ea androgenetic. Liphuputso tse teng hona joale li bontšitse hore PDRN e kopantsoe le PRP kapa 1927nm thulium fractional laser treatment e ka 'na ea e-ba khetho e ka bang teng bakeng sa bakuli ba nang le androgenetic alopecia ba sa arabeleng kalafo e tloaelehileng ea lithethefatsi. Leha ho le joalo, boholo ba lisampole bo boholo bo ntse bo hlokahala ho lekola polokeho ea eona.

E khothalelitsoeng Tšebeliso

Tšebeliso ea PDRN e fapana haholo ho pholletsa le mafu a fapaneng, 'me protocol e kopaneng ea kopo e ntse e haella.

Hona joale, lingoliloeng tsa malapeng le tsa machaba li tlaleha mekhoa ea tsamaiso ea PDRN e kenyeletsang tšebeliso ea lihlooho, ho fana ka li-intradermal, ente ea intradermal, ente ea subcutaneous, le ente ea intramuscular. Maqhubu a litekanyetso a tloha hang ka letsatsi ho isa hanngoe ka beke, 'me nako ea ho noa e tloha matsatsing a' maloa ho isa libekeng tse 'maloa. Leha ho le joalo, mekhoa e khethehileng ea tšebeliso e tlameha ho lateloa ka thata ho latela sehlopha sa sehlahisoa (sethethefatsi kapa sesebelisoa sa bongaka).

Tšireletseho le Litlhokomelo

1. PDRN e na le bohloeki ba DNA> 95% 'me ha e na liprotheine kapa li-peptide tse sebetsang ka meriana, ka hona, immunogenicity ea eona e tlaase.
2. Liphuputso tse ngata tsa kliniki li boetse li tiisitse hore PDRN e na le tšireletso e ntle le mamello ho sa tsotellehe tsela ea tsamaiso. Ha ho litlamorao tse matla tse chefo kapa litlamorao tse mpe tse bonoang kamora tšebeliso ea li-topical, leha ho ka hlaha litlamorao tse bobebe tse kang bofubelu ba letlalo, ho hlohlona le ho hlaba. Hangata matšoao ana a kokobela kapele ka mor’a ho khaotsa ho sebelisa moriana oo kapa ka phekolo ea matšoao.
3. Ho na le monyetla oa liketsahalo tse mpe tse kang granulomas ea 'mele oa linaheng tse ling le mafu a itseng ha PDRN e tsamaisoa ka ente. Ka hona, tlhokomeliso e lokela ho sebelisoa ha u sebelisa lithethefatsi tsena intradermally kapa subcutaneously.
4. PDRN e hanetsoe ho basali ba baimana le ba anyesang, ba nang le maqeba a tšoaelitsoeng, le ba aleji ho PDRN.

Kakaretso le Outlook

1. Chaena, PDRN e sebelisoa haholo-holo ka holimo le ka mesotherapy ea microneedling. Ka lebaka la litlamorao tse khahlanong le ho ruruha tsa PDRN le bokhoni ba ho lokisa lisele, lipatlisiso tsa kamoso li ka hlahloba bokhoni ba eona ba lits'ebetso tse ncha.
2. Ntle le moo, maano a tsamaiso bakeng sa PDRN kalafong ea mathata a fapaneng a letlalo, ho kenyelletsa le ho tseba tsela e nepahetseng ea tsamaiso, khafetsa, le ho tsepamisa maikutlo, hammoho le litlamorao tsa eona tsa synergistic le liphekolo tse ling, li hloka lipatlisiso tse ling.