I-recombinant human superoxide dismutase (rhSOD): Impumelelo entsha kwicandelo le-antioxidants exhotyiswe yi-biotechnology. 

Imizimba yethu ngokwemvelo ivelisa i-superoxide dismutase (SOD), kodwa imingeni emininzi yobomi banamhlanje igqithisa amandla ayo. Ukongezwa nge-SOD ayisiyiyo nje inzuzo eyongeziweyo, kodwa kunokomelezwa okuyimfuneko kumzimba. Ukukhethwa kwe-SOD yokuncedisa, nangona kunjalo, kumisela ukusebenza kunye nokukhuseleka koku kuqiniswa.

Ngaphambi kokuba sixoxe ngokuthi "yintoni eyongezelela," kufuneka siqale siqonde "kutheni kufuneka songezelele." Oku akukhona nje ngobuhle, kodwa kunye nemigaqo esisiseko yempilo.

Kutheni kuyimfuneko ukongeza nge-superoxide dismutase (SOD)?

Umzimba womntu ngokwenene unawo "umgca wemveliso ye-SOD," kodwa ngokuguga kunye notshintsho kwindlela yokuphila, "i-balance-demand balance" ye-SOD iyancipha ngokuthe ngcembe, ikhokelela ekugqithiseni kweeradicals zamahhala, ukonakalisa imisebenzi yomzimba kunye nokukhawulezisa inkqubo yokuguga.

1.Ukwaluphala:  I-SOD yomzimba "imveliso iyancipha," kwaye umthamo wayo wokukhupha uyaphela.

Ubudala be-25 buyinto ebalulekileyo: Ngaphambi kweminyaka eyi-25, izinga lomzimba we-SOD synthesis ngokulula "ukugcina" kunye nesantya semveliso yamahhala; nangona kunjalo, emva kweminyaka eyi-25, i-SOD synthesis iyancipha ngesantya se-1% -2% ngonyaka. Ngeminyaka engama-40, umsebenzi womzimba we-SOD kuphela ngama-50% wenqanaba eliphezulu, kwaye emva kweminyaka engama-60, ungaphantsi kwama-30%.

Okwangoku, ukuveliswa kwee-radicals zamahhala akunciphisi-i-cell metabolism kunye nokuphefumula ngokuqhubekayo kuvelisa i-superoxide anion free radicals. Oku kukhokelela kwi-SOD eyaneleyo, kwaye i-radicals yamahhala engaphezulu iqala ukuhlasela iiseli: i-collagen yesikhumba eyonakalisayo (ebangela imibimbi), eyonakalisa i-vascular endothelium (ukukhawuleza ukuguga kwe-vascular), kunye neeseli zesibindi ze-oxidizing (ukwandisa umthwalo we-metabolic). Esi sesinye sezizathu eziphambili "zokwaluphala."

I-2.Ubomi banamhlanje: I-Radicals yamahhala egqithisileyo, i-SOD ye-Endogenous eyaneleyo

Ngaphandle kweminyaka yobudala, iindlela zokuphila zemihla ngemihla zikwakhawulezisa ukuveliswa kweeradicals zasimahla:

Ukubonakaliswa kwe-UV: Ukutshatyalaliswa kwelanga kwiyure enye ngosuku kwandisa i-radicals yamahhala eveliswa lusu ngokuphindwe kathathu, idlula kakhulu i-SOD yomzimba (i-superoxide dismutase) yokucoca umthamo;

Ubusuku obuncinane kunye noxinzelelo: Xa ubuthongo-bunqande okanye phantsi koxinzelelo, umzimba ufihla "i-hormone yoxinzelelo," ekhuthaza ukuveliswa kwenani elikhulu lama-radicals amahhala;

Ukutya okungalunganga: Iswekile ephezulu, i-fat-fat, kunye nokutya okuthosiweyo kuvelisa iimveliso eziphakamileyo ze-glycation ekupheleni kwe-metabolism, ehamba kunye nenani elikhulu lama-radicals amahhala;

Ukungcola kwendalo: Izinto ezinobungozi kwi-smog, i-exhaust yemoto, kunye nomsi wesibini, emva kokungena emzimbeni womntu, kubangela "uxinzelelo lwe-oxidative," ekhokelela ekwandeni kwama-radicals amahhala;

Impembelelo yesifo: Iimeko ze-Pathological ezibangelwa ukugula kunye nenkqubo ye-metabolism yeziyobisi zombini zenza uxinzelelo lwe-oxidative emzimbeni, lube ngabaqhubi ababalulekileyo bokunyuka okungaqhelekanga kwee-radicals zamahhala.

I-3.I-SOD yomzimba ngokwayo "inamandla alinganiselwe" kwaye ayikwazi ukujamelana "nokuhlaselwa okugxininisekileyo."

Nakubantu abancinci abaphila impilo enempilo, i-SOD yomzimba inezithintelo zayo: igxininiswe kakhulu ngaphakathi kweeseli kwaye ibonelele ngokungonelanga kwi-radicals yamahhala egazini nangaphezulu kwesikhumba; ngaphezu koko, umsebenzi wayo awuphezulu ngokwaneleyo ukuphelisa ngokufanelekileyo i-radicals yamahhala ngexesha "lokugqabhuka okugxininisiweyo" (njengasemva kokuphuma kwelanga okanye umthambo onzima).

Kulapho ukongeza nge-SOD kuba yimfuneko-kufana nokongeza "izicoci ezisebenza kakuhle" emzimbeni ukunceda ukususa ngokukhawuleza iiradicals zasimahla kunye nokuthintela ukonakala kweeseli okuqhubekayo.