Yintoni kanye kanye i-PDN? Kutheni kunconywa “njengesitshixo kunyango oluhlaziyayo”? 

Kwiinkalo ze-skincare kunye neyeza lobuhle, "ukuvuselelwa" ngumbono othakazelisayo. Xa ulusu lonakele okanye lugugile, sihlala sinethemba lokuvusa amandla alo okulungisa. I-PDRN kanye “isitshixo” esifunyenwe luluntu lwenzululwazi kutshanje ukuze lusebenze ngokuchanekileyo iinkqubo zokulungisa iiseli. Namhlanje, siza kutyhila iimfihlakalo zayo.

Imvelaphi: Impembelelo evela kumandla okuhlaziya olwandle

I-PDRN (i-Polydeoxyribonucleotide), egama layo elipheleleyo yi-polydeoxyribonucleotide, ayiyona imveliso eyenziwe ngamachiza, kodwa kunokuba ivela kwiiseli zokuzala ze-salmon zendalo.

Izazinzulu ziye zafumanisa ukuba i-salmon inamandla okuvuselela izicubu kunye nokulungisa. Ngophando olongezelelweyo, bakhupha le DNA fragment-PDRN-ukusuka kwi-salmon sperm. Le DNA ifana kakhulu kwisakhiwo esisisiseko kwi-DNA yazo zonke izilwanyana ezincelisayo (kubandakanywa nabantu), ibonisa i-biocompatibility egqwesileyo kunye nomngcipheko ophantsi wokulahlwa kwamajoni omzimba, ngaloo ndlela ivumela ukusetyenziswa kwayo ngokukhuselekileyo nokusebenzayo emzimbeni womntu.

Undoqo: Ayisiyonto nje “izinto ezingasetyenziswanga,” kodwa “luphawu.”

Sinokuyiqonda indlela yokusebenza kwePDN kwiimbono ezimbini eziphambili:

"Njengezinto zokulungisa": I-PDRN yenziwe ngee-deoxyribonucleotides ezininzi (iiyunithi ezisisiseko ze-DNA). Xa izicubu zolusu zonakalisiwe kwaye iiseli zifuna ukwahlula kwaye zande ukuze zigqibe ukulungiswa, ezi nucleotide zifumaneka ngokulula zinokusetyenziswa ngokuthe ngqo kwiiseli njengezinto eziluhlaza zokwenza i-DNA entsha, ngaloo ndlela ikhawulezisa inkqubo yokulungisa.

Njengophawu "lokulungisa": Le yeyona ndlela ibaluleke kakhulu kwaye iyodwa yesenzo sePDN. I-PDRN inokuqatshelwa ngokuthe ngqo ngamaseli ajikeleze izicubu ezonakalisiweyo okanye i-hypoxic kwaye ibophe kwi-adenosine i-A2A i-receptors kwi-cell surface, inqanda i-NF-kB kunye ne-MAPK iindlela zokubonisa iimpawu eziqhutywe yi-ROS.  Oku kunciphisa ukuveliswa kwe-cytokines e-pro-inflammatory (IL-6, IL-1β, TNF-α, njl.) kwaye ikhuthaza ukubonakaliswa kwee-cytokines ezichasayo (IL-10), ngaloo ndlela zisebenzisa umphumo onamandla wokuchasa.  Ngaphezu koko, ivuselela ukukhuselwa kwe-EGF (i-epidermal growth factor), i-FGF (i-fibroblast factor factor), i-VEGF (i-vascular endothelial growth factor), kunye ne-angiopoietin, inika i-PDRN egqwesileyo yokuchasa ukudumba kunye neempawu zokuphulukisa amanxeba.

Umsebenzi ongundoqo: Ikhonkco lokulungisa ukusuka kwi-micro ukuya kwinqanaba elikhulu.

Ngokusekwe kwiindlela ezichazwe ngasentla, iPDRN isebenzisa uluhlu lweziphumo ezilungileyo ezidibeneyo kwinqanaba lesikhumba:

Ikhuthaza i-angiogenesis: Yandisa ukunikezelwa kwegazi kwindawo eyonakeleyo, izisa ioksijini eninzi kunye nezondlo kunye nokususa inkunkuma ye-metabolic.

Ukukhuthaza ukwanda kweeseli kunye nokufuduka: Ukukhawuleza umsebenzi kunye nenani leeseli eziphambili zokulungisa ezifana ne-fibroblasts kunye ne-keratinocytes.

Ivuselela i-collagen kunye ne-elastin synthesis: Yomeleza isakhiwo sesikhumba esivela kwi-dermis, ukuphucula imigca emihle kunye nokwandisa ukuqina.

Impembelelo enamandla yokuchasana nokudumba: Ithomalalisa ngokufanelekileyo ukudumba okunjengobomvu, ukudumba, ubushushu, kunye neentlungu ngokulawula izinto ezivuthayo.

Ukulungiswa kwezicubu kunye nokuphiliswa kwenxeba:  Ukudibanisa zonke ezi ziphumo zingentla, kukhawulezisa inkqubo yokuphola kokwenzakala okwahlukeneyo kulusu.

I-PDRN ibizwa ngokuba "sisitshixo sokuvuselelwa" kuba ayilungisi nje kwaye yondle, kodwa ilawula ngokuchanekileyo ukusebenza kweeseli.  Ngokusekwe kwi-biocompatibility ephezulu, yenza ukuba ulusu lukwazi ukuphinda luhlaziyeke ngeendlela ezininzi. Le ndlela "yokuvusa amandla okulungisa ngaphakathi" yeyona nto iphambili kwinkalo yokuhlaziywa kwakhona, kwaye yeyona nto inika i-PDRN indawo yayo engenakubuyiselwa kwinkalo yempilo yolusu.