Ukutyhilwa kwePDN: Ngaba esi sithako sifunwa kakhulu emva kokhathalelo lwesikhumba sisixhobo sokuthengisa okanye ngaba sizisa iziphumo ngokwenene? 

Kutshanje, i-PDRN (i-polydeoxyribonucleotide) iye yavela rhoqo kwizixhobo zokuthengisa zeskipa esisebenzayo kunye neemveliso zobuhle zonyango.  Iileyibhile ezinje nge "inaliti ye-salmon ye-salmon" kunye "nokulungiswa kwenqanaba le-DNA" ngokukhawuleza kuyenze yathandwa, kodwa yavusa impikiswano: Ngaba le yinto nje yokuthengisa eyenziwe yinkunzi, okanye ngaba sisithako esisebenzayo ngokwenene esineenzuzo ezinkulu? Eli nqaku liza kuhlalutya ixabiso lokwenene le-PDRN kwimbono yesayensi, ukudibanisa uphando lweklinikhi kunye nedatha yesicelo seshishini.

Inkcazo engundoqo kunye nengqiqo yokusebenza yePDN

I-PDRN i-polymer eyenziwe yi-deoxyribonucleotides edityaniswe ngamabhondi e-phosphodiester, enobunzima be-molecular ukusuka kwi-50 ukuya kwi-1500 kDa. Umsebenzi wayo ongundoqo webhayoloji uvela kwisakhiwo se-adenosine. Okwangoku, imathiriyeli ethotyelwayo ekrwada itsalwa ikakhulu kwiiseli zokuzala zesalmon, kodwa zinokulungiswa ngokuvutshelwa kwe-microbial kunye neendlela zebhayoloji zokwenziwa, kwaye zifuna iimvavanyo ezininzi zokucoceka kwe-nucleic acid kunye nomsebenzi webhayoloji.

Indlela yokusebenza kwayo inesiseko esicacileyo sebhayoloji, ikakhulu yahlulwe yaba ziindlela ezimbini:

I-1.Indlela yokulawula i-Anti-inflammatory: Njenge-adenosine i-A2A i-receptor agonist, inokunyusa ngokuchanekileyo i-anti-inflammatory factor IL-10 kunye nokunciphisa i-pro-inflammatory factor IL-6 kunye ne-TNF-α, ukulinganisa i-microenvironment yesikhumba kunye nokuthintela umonakalo woxinzelelo lwe-oxidative;

I-2.Ukulungiswa kunye nendlela yokudibanisa: Njenge-nucleotide precursor ye-cell DNA synthesis, inokubonelela ngezinto eziluhlaza zokwakhiwa ngokutsha kwezinto zofuzo kwiiseli ezonakalisiweyo, ukukhawuleza ukwanda kwe-epidermal kunye nokulungiswa kwesakhiwo somqobo. Lo matshini uqinisekisiwe kwiimvavanyo ezininzi zeeseli ze-vitro kunye nezifundo zeklinikhi.

Ukuqinisekisa ukusebenza kakuhle: Imisebenzi engundoqo exhaswa luphando.

I-1.Barrier Repair kunye ne-Anti-inflammatory Soothing: I-Clinical Proven Core Advantages

Kwinkalo ye-dermatology, i-PDRN inedatha ecacileyo exhasa ukusebenza kwayo ekuphuculeni umonakalo onomqobo kunye neengxaki zesikhumba ezivuthayo. Izifundo zeklinikhi zibonisa ukuba amalungiselelo aqukethe i-PDRN anokuphucula kakhulu iimpawu zobomvu kwi-erythematotelangiectatic rosacea, kunye nokunciphisa okuqhelekileyo kwe-32.7% kwindawo ye-erythema emva kweeveki ezi-4 zokusetyenziswa; ngenxa yamanxeba enkqubo ye-post-cosmetic, inokunciphisa ixesha lokuphulukisa i-epidermal nge-20% ukuya kwi-30%, kunye nokunciphisa ubomvu be-post-operative, ukuvuvukala, ukushisa, kunye neentlungu.

Ngaphaya koko, kuvavanyo lwesicelo se-atopic dermatitis, i-PDRN yanciphisa amanqaku okurhawuzelela ulusu kunye nokwanda kwe-stratum corneum hydration. Oku akusiyo i-jargon yokuthengisa, kodwa ukubonakaliswa ngokuthe ngqo kweendlela zayo ezichasayo kunye nokulungisa.

I-2.I-Whitening kunye ne-Anti-aguga: Ibonakaliswe ukuba iSebenzisa kwiNqanaba elingunobangela

Iimvavanyo ze-in vitro cell ziye zaqinisekisa ukuba i-PDRN inokuthintela umsebenzi we-tyrosinase (izinga lokuthintela malunga ne-28%), ukunciphisa ukubonakaliswa kweeprotheni ezilawula i-melanin ezifana ne-MITF, kunye nokunciphisa ukuveliswa kwe-melanin; kwangaxeshanye, inokuphucula umsebenzi we-fibroblast mitochondrial, inhibit matrix metalloproteinase MMP-1, kwaye ikhuthaze i-collagen synthesis.

3.UkuKhuselwa koMfanekiso: Ukulungiswa kwenqanaba leDNA ekujoliswe kulo

Emva kokukhanya kwe-UV, iiseli zesikhumba zifumana umonakalo weDNA. I-PDRN inokukhawuleza isebenze indlela yeprotheyini ye-p53 ukuqalisa iindlela zokulungisa i-DNA, ukunciphisa ukuguqulwa kwemfuza okubangelwa yi-UV, kunye nokunciphisa umngcipheko we-photoaging kunye ne-photodamage. Esi siphumo siqinisekisiwe kwimifuniselo yemodeli yeseli edibeneyo kwaye yenye yeenzuzo zayo ezingundoqo eziyahlula kwizinto eziqhelekileyo ze-antioxidant.

Iindawo zokusetyenziswa: ukusuka kwiimfuno zonyango eziyimfuneko ukuya kwizicelo ezandisiweyo kukhathalelo lwesikhumba.

Ukusetyenziswa kwePDN akuzange kuqale ngokuthengisa i-skincare; ixabiso layo laqatshelwa kwicandelo lezonyango, kwaye kamva ngokuthe ngcembe landiswa ukuya kwi-aesthetics yonyango kunye ne-skincare esebenzayo. Ukusebenza kwiimeko ezahlukeneyo kunemida ecacileyo.

1.Ummandla woNyango:

Ekuqaleni kwe-2008, inkampani yaseNtaliyane uMastelli yaqalisa inaliti yokuqala ye-PDRN yamayeza, i-Placentex, esetyenziselwa ukulungiswa kwezilonda ezingapheliyo (izilonda zeenyawo zesifo seswekile, izilonda ezivuthayo), umonakalo we-corneal kunye nomonakalo wamathambo. Idatha yeklinikhi ibonisa ukuba izinga layo elisebenzayo ekuphulukiseni amanxeba anzima-ukuphulukisa anokufikelela kwi-76.5%, okwenza kube yinto encedisayo eyaziwayo ekliniki yokulungiswa kwezicubu.

2.Ummandla we-Medical Aesthetics:

Kwintsimi ye-aesthetics yonyango, i-PDRN yaziwa ngokuba yi "salmon DNA" ngenxa yemithombo yayo kwaye isetyenziswa ngokubanzi kwi-mesotherapy kunye nokulungiswa kwe-post-microneedling. I-Korean Food and Drug Administration (KFDA) yayiquka njengesithako esithobelayo sokutshintshwa kwezicubu kunye nonyango lwamanxeba ngo-2008, ukukhawuleza ukuphiliswa kwamanxeba amancinci kwi-aesthetics yonyango, ukuphucula ubomvu kwisikhumba esibucayi kunye nokuthungwa kwesikhumba esirhabaxa. Iziphumo zayo ziye zaqinisekiswa yingxelo yeklinikhi evela kumaziko e-aesthetics yonyango.

3.Ummandla oSebenzayo wokhathalelo lwesikhumba:

Ngenkqubela phambili yetekhnoloji, iPDRN ifakwe ngempumelelo kwiimveliso zokhathalelo lwesikhumba. Ngeengxaki zolusu ezibangelwa ukucocwa okugqithisileyo, iipeli zekhemikhali, okanye unyango lwe-post-laser, olufana nesithintelo solusu esibuthathaka, ubomvu, kunye nokoma, i-PDRN ye-topical ibonelela ngemiqondiso yokulungisa ephezulu xa kuthelekiswa nezithako eziqhelekileyo zokuthambisa. Ayinakuyiphatha ngokuthe ngqo ingxaki, kodwa kunoko idala i-microenvironment engcono yokulungiswa kwesikhumba ngokunciphisa ukuvuvukala kunye nokukhuthaza ukuhlukana okunempilo kweekeratinocytes.

Uninzi lwama-creams, i-serum, okanye i-ampoules yokulungisa i-high-end-high-end-ampoules iyisebenzisa njengento ephambili, igxininisa "ukomeleza kunye nokulungiswa" kunye nemiphumo "yokuguga kunye nokuzinzisa".  Ihlala idibaniswa kunye nezithintelo zokulungisa izithintelo ezifana ne-ceramides kunye ne-centella asiatica extract ukuze iphucule ukusebenza kwayo, kwaye iphinde idibaniswe ne-antioxidants (efana ne-SOD) ukukhusela umonakalo we-oxidative ngelixa ulungisa ulusu.

Ukuqukumbela

I-PDRN ayisiyiyo igimmick yokuthengisa; iziphumo zayo ezichasayo kunye nokubuyisela, kunye nokukhuselwa kwinqanaba le-DNA, zixhaswa ngeendlela eziqinileyo zezinto eziphilayo kunye neenkcukacha zeklinikhi.  Ixabiso layo eliphambili liboniswa kwizicelo ezivela ekuphulukisweni kwenxeba lonyango ukuya kukhathalelo lwenkqubo ye-post-cosmetic. Nangona kunjalo, kwimakethi esebenzayo yokhathalelo lwesikhumba, ezinye iibrendi zibandakanyeka kwiindlela zokuthengisa ezilahlekisayo, ezinje ngokubaxa ukugxila kunye namabango okusebenza.

Abathengi kufuneka baqonde ukuba: i-PDRN ye-medical-grade (i-injected / microneedled) inika imiphumo ebalulekileyo yokubuyisela kwaye ifanelekile kwiinkqubo ze-post-cosmetic okanye izithintelo zesikhumba ezonakalisiweyo kakhulu; Iimveliso ze-PDRN ze-skincare ze-topical zilungele ukulungiswa kwemihla ngemihla kunye nokugcinwa kolusu olubuthathaka, kunye neenjongo zokuchasa ukuguga kunye neenjongo ezimhlophe kukhathalelo lwesikhumba. Ukuqonda okunengqiqo kwexabiso lezithako kubalulekile ukunqanda imigibe yokuthengisa.