Ukwembula i-PDRN: Ingabe lesi sithako esifunwa kakhulu sokunakekelwa kwesikhumba siwubuciko bokumaketha noma siletha imiphumela ngempela? 

Muva nje, i-PDRN (i-polydeoxyribonucleotide) ivame ukuvela ezintweni zokukhangisa zokunakekelwa kwesikhumba okusebenzayo kanye nemikhiqizo yobuhle bezokwelapha.  Amalebula anjengokuthi “umjovo we-DNA ye-salmon” kanye “nokulungiswa kwezinga le-DNA” akwenze kwaduma ngokushesha, kodwa futhi kwaqubula impikiswano: Ingabe lokhu kumane kuyiqhinga lokumaketha elenziwe ngosozimali, noma ingabe kuyisithako esisebenzayo esisebenza ngempela esinezinzuzo ezinkulu? Lesi sihloko sizohlaziya inani langempela le-PDRN ngokombono wesayensi, okuhlanganisa ucwaningo lwezokwelapha kanye nedatha yesicelo semboni.

Incazelo ewumongo kanye nokusebenza kahle kwe-PDRN

I-PDRN iyi-polymer eyakhiwe yi-deoxyribonucleotides exhunywe amabhondi e-phosphodiester, enesisindo samangqamuzana asuka ku-50 kuya ku-1500 kDa. Umsebenzi wayo owumgogodla webhayoloji usuka esakhiweni se-adenosine. Njengamanje, izinto zokusetshenziswa ezithobelayo zikhishwa ikakhulukazi kumaseli okuzala ama-saumoni, kodwa futhi zingalungiselelwa ngokusebenzisa amasu e-microbial fermentation kanye nezindlela zokwenziwa zebhayoloji, futhi zidinga ukuhlolwa okuningi kokuhlanzeka kwe-nucleic acid kanye nomsebenzi webhayoloji.

Indlela yayo yokusebenza inesisekelo esicacile sebhayoloji, ikakhulukazi ihlukaniswe izindlela ezimbili:

I-1.Indlela yokulawula yokulwa nokuvuvukala: Njenge-adenosine A2A receptor agonist, ingakwazi ukuqondisa ngokunembile isici sokulwa nokuvuvukala kwe-IL-10 futhi yehlise izici eziphikisana nokuvuvukala i-IL-6 ne-TNF-α, ukulinganisa i-microenvironment yesikhumba kanye nokuvimbela ukulimala kokucindezeleka kwe-oxidative;

I-2.Ukulungisa kanye nendlela yokuhlanganisa: Njengesandulela se-nucleotide ye-cell DNA synthesis, ingahlinzeka ngezinto ezingavuthiwe zokwakhiwa kabusha kwezakhi zofuzo kumaseli awonakele, ukusheshisa ukwanda kwe-epidermal kanye nokulungiswa kwesakhiwo sokuvimbela. Lo mshini uqinisekisiwe ezivivinyweni eziningi ze-in vitro cell kanye nezifundo zomtholampilo.

Ukuqinisekisa ukusebenza kahle: Imisebenzi ebalulekile esekelwa ucwaningo.

1.Ukulungiswa Kwezithiyo kanye Nokunciphisa Ukuvuvukala: Izinzuzo Eziyinhloko Ezifakazelwe Ngomtholampilo

Emkhakheni we-dermatology, i-PDRN inedatha ecacile esekela ukusebenza kahle kwayo ekuthuthukiseni ukulimala kwesithiyo kanye nezinkinga zesikhumba ezivuvukalayo. Ucwaningo lwezokwelapha lubonisa ukuthi amalungiselelo aqukethe i-PDRN angathuthukisa kakhulu izimpawu zokubomvu ku-erythematotelangiectatic rosacea, ngokunciphisa isilinganiso se-32.7% endaweni ye-erythema ngemva kwamasonto angu-4 okusetshenziswa; ngezilonda zezinqubo ze-post-cosmetic, zinganciphisa isikhathi sokuphulukiswa kwe-epidermal ngo-20% kuya ku-30%, futhi kunciphise ukubomvu kwangemva kokuhlinzwa, ukuvuvukala, ukushisa, nobuhlungu.

Ngaphezu kwalokho, ekuhlolweni kwesicelo se-topical se-atopic dermatitis, i-PDRN yehlisa ukuluma kwesikhumba kanye nokwanda kwe-stratum corneum hydration. Lena akuyona i-jargon yokuthengisa, kodwa ukubonakaliswa okuqondile kwezindlela zayo zokulwa nokuvuvukala nokulungisa.

2.Ukuba mhlophe kanye nokunqanda ukuguga: Kufakazelwe ukuthi kusebenza emsuka wembangela

Ukuhlolwa kwe-in vitro cell kuqinisekisile ukuthi i-PDRN ingavimbela umsebenzi we-tyrosinase (izinga lokuvimbela cishe i-28%), yehlise ukubonakaliswa kwamaprotheni alawula i-melanin njenge-MITF, futhi inciphise ukukhiqizwa kwe-melanin; ngesikhathi esifanayo, ingathuthukisa umsebenzi we-fibroblast mitochondrial, ivimbele i-matrix metalloproteinase MMP-1, futhi ikhuthaze ukuhlanganiswa kwe-collagen.

3.Ukuvikelwa Kwesithombe: Ukulungiswa kwezinga le-DNA ehlosiwe

Ngemuva kokukhishwa kwemisebe ye-UV, amaseli esikhumba athola ukulimala kwe-DNA. I-PDRN ingavula ngokushesha indlela ye-p53 yamaprotheni ukuze iqalise izindlela zokulungisa i-DNA, inciphise ukuguqulwa kwezakhi zofuzo ezibangelwa yi-UV, futhi yehlise nengozi yokuthwebula izithombe nokonakala kwezithombe. Lo mphumela uqinisekisiwe ekuhlolweni kwemodeli yeselula enezithombe futhi ingenye yezinzuzo zayo eziyinhloko eziwuhlukanisa nezithako ezijwayelekile zokulwa ne-antioxidant.

Izindawo zokufaka isicelo: kusukela ezidingweni ezibalulekile zezokwelapha kuye kwezandisiwe izicelo zokunakekelwa kwesikhumba.

Ukusetshenziswa kwe-PDRN akuzange kuqale ngokumaketha kwe-skincare; ukubaluleka kwayo kwaqashelwa okokuqala emkhakheni wezokwelapha, futhi kamuva kwanwetshwa kancane kancane kwaba ubuhle bezokwelapha nokunakekelwa kwesikhumba okusebenzayo. Ukusebenza kahle ezimeni ezahlukene kunemingcele ecacile.

1.Inkundla yezokwelapha:

Kusukela ngo-2008, inkampani yase-Italy i-Mastelli yethula umjovo wokuqala we-PDRN wezokwelapha, i-Placentex, esetshenziselwa ukulungiswa kwezilonda ezingapheli (izilonda ezinyaweni zesifo sikashukela, izilonda ezishisayo), ukulimala kwe-cornea kanye nokulimala kwamathambo. Idatha yomtholampilo ikhombisa ukuthi izinga layo elisebenzayo ekwelapheni amanxeba okunzima ukupholisa lingafinyelela ku-76.5%, okulenza libe yingxenye yosizo eyaziwa ngokomtholampilo yokulungisa izicubu.

2.Inkundla ye-Medical Aesthetics:

Emkhakheni we-aesthetics yezokwelapha, i-PDRN yaziwa kakhulu ngokuthi “i-salmon DNA” ngenxa yezinto eziwumthombo wayo futhi isetshenziswa kabanzi ku-mesotherapy nokulungisa i-post-microneedling. I-Korean Food and Drug Administration (KFDA) yayifaka njengesithako esithobelanayo sokufakelwa kwezicubu nokwelashwa kwamanxeba ngo-2008, isheshisa ukuphulukiswa kwezilonda ezingavamisile kubuhle bezokwelapha, ukuthuthukisa ububomvu esikhumbeni esibucayi kanye nokuthungwa kwesikhumba esimahhadlahhadla. Imiphumela yayo iqinisekiswe yimpendulo yomtholampilo evela ezikhungweni zobuhle bezokwelapha.

3.Inkundla ye-Skincare esebenzayo:

Ngokuthuthuka kwezobuchwepheshe, i-PDRN ifakwe ngempumelelo emikhiqizweni yokunakekelwa kwesikhumba. Ezinkingeni zesikhumba ezibangelwa ukuhlanzeka ngokweqile, ukuxebuka kwamakhemikhali, noma ukwelashwa kwe-post-laser, okufana nesithiyo sesikhumba esibuthakathaka, ububomvu, nokoma, i-PDRN yasendaweni inikeza izimpawu zokulungisa eziphakeme uma kuqhathaniswa nezithako ezijwayelekile zokuthambisa. Ayiphathi ngokuqondile inkinga, kodwa kunalokho idala i-microenvironment engcono yokuzilungisa isikhumba ngokunciphisa ukuvuvukala nokukhuthaza ukuhlukaniswa okunempilo kwama-keratinocyte.

Ama-creams amaningi asezingeni eliphezulu, ama-serum, noma ama-ampoules ayisebenzisa njengesithako esiyinhloko, egcizelela "ukuqinisa nokulungisa" kanye "nemiphumela yokulwa nokuguga nokuzinza".  Ivame ukuhlanganiswa nezithako zokulungisa izithiyo ezifana ne-ceramides ne-centella asiatica extract ukuze kuthuthukiswe ukusebenza kwayo, futhi iphinde ihlanganiswe nama-antioxidants (njenge-SOD) ukuvikela emonakalweni we-oxidative ngenkathi kulungiswa isikhumba.

Isiphetho

I-PDRN ayiyona i-gimmick yokumaketha; imiphumela yayo elwa nokuvuvukala nebuyisela emuva, kanye nokuvikelwa kwayo kwezinga le-DNA, isekelwa izindlela eziqinile zezinto eziphilayo kanye nedatha yomtholampilo.  Inani layo eliyinhloko liboniswa ezinhlelweni zokusebenza kusukela ekuphulukisweni kwesilonda sezokwelapha kuya ekunakekelweni kwenqubo yangemva kwezimonyo. Kodwa-ke, emakethe ye-skincare esebenzayo, amanye amabhrendi abandakanyeka ezindleleni zokumaketha ezidukisayo, njengokugxilisa ihaba kanye nezimangalo zokusebenza kahle.

Abathengi kufanele baqonde ukuthi: i-PDRN ye-medical-grade (injected/microneedled) inikeza imiphumela ebalulekile yokubuyisela futhi ifanele izinqubo zangemuva kwezimonyo noma izithiyo zesikhumba ezilimele kakhulu; Imikhiqizo ye-PDRN ye-topical skincare ilungele ukulungiswa nokugcinwa kwansuku zonke kwesikhumba esibucayi, kanye nezinjongo zokulwa nokuguga kanye nokwenza mhlophe ekunakekeleni isikhumba. Ukuqonda okunengqondo kwevelu yesithako kubalulekile ukugwema izingibe zokumaketha.