Iyini ngempela i-PDRN? Kungani idunyiswa “njengesihluthulelo somuthi ovuselelayo”? 

Emkhakheni we-skincare kanye nemithi yobuhle, "ukuvuselelwa" kuwumqondo othakazelisayo. Uma isikhumba silimele noma sigugile, sihlala sinethemba lokuvusa amakhono aso okulungisa emvelo. I-PDRN iyona kanye “ukhiye” umphakathi wesayensi osanda kuwuthola ukuze wenze kusebenze izinqubo zokulungisa amaselula. Namuhla, sizokwembula izimfihlakalo zayo.

Umsuka: Ugqozi oluvela emandleni olwandle okuvuselela kabusha

I-PDRN (i-Polydeoxyribonucleotide), igama layo eliphelele i-polydeoxyribonucleotide, ayiwona umkhiqizo owenziwe ngamakhemikhali, kodwa kunalokho itholakala kumaseli okuzala ama-salmon emvelo.

Ososayensi bathole ukuthi i-salmon inamakhono anamandla okuvuselela izicubu nokulungisa. Ngokucwaninga okwengeziwe, bakhiphe lesi siqeshana se-DNA-PDRN-kusuka ku-salmon isidoda. Le DNA ifana kakhulu nesakhiwo esiyinhloko ku-DNA yazo zonke izilwane ezincelisayo (kuhlanganise nabantu), ibonisa ukuhambisana okuhle kakhulu kwe-biocompatibility kanye nengozi ephansi yokwenqatshwa kwamasosha omzimba, ngaleyo ndlela ivumela ukusetshenziswa kwayo okuphephile nokusebenza ngempumelelo emzimbeni womuntu.

Ingqikithi: Akuyona nje "impahla eluhlaza," kodwa futhi "isignali."

Singaqonda indlela yokusebenza ye-PDRN emibonweni emibili ewumongo:

“Njengempahla yokulungisa”: I-PDRN yakhiwe ngama-deoxyribonucleotides amaningi (amayunithi ayisisekelo e-DNA). Lapho izicubu zesikhumba zilimele futhi amangqamuzana edinga ukuhlukana futhi ande ukuze aqedele ukulungiswa, lawa ma-nucleotide atholakala kalula angasetshenziswa ngokuqondile amangqamuzana njengezinto ezingavuthiwe zokuhlanganisa i-DNA entsha, ngaleyo ndlela kusheshiswe inqubo yokulungisa.

“Njengesiginali yokulungisa”: Lena indlela ebaluleke kakhulu futhi eyingqayizivele yokusebenza kwe-PDRN. I-PDRN ingabonwa ngokuqondile ngamaseli azungeze izicubu ezilimele noma ze-hypoxic futhi ibophezele kuma-adenosine A2A receptors endaweni yeseli, evimbela izindlela zokusayina ze-NF-kB ne-MAPK ezicushwe yi-ROS.  Lokhu kunciphisa ukukhiqizwa kwe-cytokines e-pro-inflammatory (IL-6, IL-1β, TNF-α, njll.) futhi ikhuthaza ukubonakaliswa kwama-cytokines aphikisana nokuvuvukala (IL-10), ngaleyo ndlela yenze umphumela onamandla wokulwa nokuvuvukala.  Ngaphezu kwalokho, ivuselela ukukhiqizwa kwe-EGF (i-epidermal growth factor), i-FGF (i-fibroblast growth factor), i-VEGF (i-vascular endothelial growth factor), ne-angiopoietin, inikeze i-PDRN izinto ezinhle kakhulu zokulwa nokuvuvukala nokuphulukisa isilonda.

Umsebenzi oyinhloko: Iketango lokulungisa ukusuka ku-micro kuya ezingeni elikhulu.

Ngokusekelwe kuzinqubo ezichazwe ngenhla, i-PDRN isebenzisa uchungechunge lwemiphumela emihle exhumene ezingeni lesikhumba:

Ithuthukisa i-angiogenesis: Ikhuphula ukutholakala kwegazi endaweni eyonakele, ilethe umoya-mpilo owengeziwe kanye nezakhamzimba futhi isuse udoti we-metabolic.

Ithuthukisa ukwanda kwamaseli nokufuduka: Isheshisa umsebenzi kanye nenani lamaseli okulungisa abalulekile njengama-fibroblasts nama-keratinocyte.

Ivuselela i-collagen ne-elastin synthesis: Iqinisa ukwakheka kwesikhumba kusuka ku-dermis, ithuthukise imigqa emihle futhi ikhulise ukunwebeka.

Umphumela onamandla wokulwa nokuvuvukala: Ipholisa ngokuphumelelayo ukusabela kokuvuvukala okufana nokubabomvu, ukuvuvukala, ukushisa, nobuhlungu ngokulawula izici zokuvuvukala.

Ukulungisa izicubu nokuphola kwesilonda:  Ukuhlanganisa yonke imiphumela engenhla, kusheshisa kakhulu inqubo yokuphola yokulimala okuhlukahlukene kwesikhumba.

I-PDRN ibizwa ngokuthi "ukhiye wokuvuselelwa kabusha" ngoba ayigcini nje ngokulungisa futhi yondle, kodwa ilawula ngokunembile ukusebenza kwamaseli.  Ngokusekelwe ku-biocompatibility yayo ephezulu, yenza kusebenze amandla esikhumba okuvuselela amandla ngokusebenzisa imiphumela ye-synergistic yezindlela eziningi. Lo mshini “wokuvusa amandla okulungisa angaphakathi” uwumgomo oyinhloko emkhakheni wokuvuselelwa kabusha, futhi yikho okunikeza i-PDRN isikhundla sayo esingenakushintshwa emkhakheni wezempilo yesikhumba.